2015 Translation Machinery in Health & Disease Gordon Research Conference

2015年健康翻译机

• 批准号: 8831351
• 负责人: Xiang-Lei Yang
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-01 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8831351
• 关键词: Academia; Address; Amino Acyl-tRNA Synthetases; Anemia; Area; Autoimmune Process; Autoimmunity; Bacterial Infections; Basic Science; Biological; Biology; Biotechnology; California; Cell physiology; Cells; Clinic; Clinical; Code; Collaborations; Communicable Diseases; Complex; Development; Diabetes Mellitus; Discipline; Disease; Elements; Fill-It; Goals; Health; Hematological Disease; Human; Immune System Diseases; Industry; Maintenance; Malignant Neoplasms; Metabolic Diseases; Minority; Mitochondrial Diseases; Myositis; Nerve Degeneration; Nucleic Acids; Organism; Participant; Pathologic Processes; Pharmacologic Substance; Physiological; Process; Protein Biosynthesis; Proteins; Regulation; Request for Applications; Research; Research Personnel; Ribosomal Proteins; Ribosomes; Role; Scientist; Series; Structure; System; Time; Transfer RNA; Translation Alteration; Translations; Vascular Diseases; Virus Diseases; Woman; Work; genetic information; human disease; innovation; interest; lectures; meetings; nervous system disorder; novel; posters; public health relevance; symposium; therapeutic development; translation factor

 DESCRIPTION (provided by the applicant): This application requests partial support for a meeting on Translation Machinery in Health & Disease - Protein Synthesis and Beyond as part of the Gordon Research Conference series to be held in Ventura, California, on February 22-27, 2015. This Conference is a new GRC and the first disease-focused, interdisciplinary conference for the broad field of translation. The conference fills a niche that is not addressed by any existing conferences on translation and the translation machinery, which mainly focus on structures of the translation machinery, and its specific functions and regulations in protein synthesis, and not on the "new biology" of this same machinery, the pathological consequence of an altered translation apparatus, or on how translation regulates diverse systems in humans. However, GRC presently has no meeting devoted to translation per se. This circumstance provides an excellent opportunity to develop, under the auspices of the GRC, a new conference to bridge translation to health and disease. The broad and long-term goal of the conference is to deepen our understanding of translation and its connection to health and disease, and to open doors to developing novel treatments and therapies. The conference will cover many disease areas including cancer, neurological diseases, immunological diseases, infectious diseases, hematological and vascular diseases, metabolic diseases, and mitochondrial diseases. The conference will present for the first time a forum for clinicians and basic scientists to discuss their distinct but overlapping interests in these translation-related molecules and diseases. The specific aims of this meeting are to convene 38-46 leading experts that cover critical basic science and clinical topics, with a total of 150 participants, for a five-day meeting. The meeting will be organized into nine sessions including an opening session on the first day featuring 2 keynote lectures, followed by 8 sessions that each focus on a specific disease area. Four additional keynote lectures will start each day for the remaining 4 days of the conference, to provide high-level introductions on topics that are relevant for the day's sessions. The keynote lectures will be given by Drs. Ada Yonath, Paul Schimmel, Nahum Sonenberg and Jonathan Weissman, with two more to be announced. Among them, Dr. Yonath is a Nobel laureate best known for her groundbreaking work on the structure and function of ribosomes; Dr. Schimmel is the most renowned scientist in the tRNA synthetase field, and an entrepreneur who has transferred basic science into therapies through many successful biotechnology companies that he has founded. In addition, four afternoon poster sessions will permit all participants to contribute to the meeting. As with all Gordon Conferences there will be numerous opportunities for young investigators, women, and minorities to interact with senior leaders in the field. As the first disease-focused conference for the field of translation, this conference would significantly impact our understanding of many important diseases-such as autoimmune myositis, cancer, neurodegeneration, diabetes, anemia, and viral and bacterial infections-and their treatment.

 描述（由申请人提供）：本申请要求对将于2015年2月22日至27日在加州文图拉举行的戈登研究会议系列的一部分，即健康与疾病中的翻译机制-蛋白质合成及其他会议提供部分支持。本次会议是一个新的GRC，也是翻译广泛领域的第一个以疾病为重点的跨学科会议。会议填补了一个利基，这是没有解决任何现有的翻译和翻译机制，主要集中在翻译机制的结构，其特定的功能和蛋白质合成的规定，而不是在“新生物学”的同一个机器，改变翻译设备的病理后果，或翻译如何调节人类的不同系统。然而，小组委员会目前没有专门讨论翻译问题的会议。这种情况提供了一个极好的机会，在GRC的主持下，开发一个新的会议，以连接翻译到健康和疾病。会议的广泛和长期目标是加深我们对翻译及其与健康和疾病的联系的理解，并为开发新的治疗和疗法打开大门。会议将涵盖许多疾病领域，包括癌症、神经系统疾病、免疫性疾病、传染病、血液和血管疾病、代谢性疾病和线粒体疾病。会议将首次为临床医生和基础科学家提供一个论坛，讨论他们在这些预防相关分子和疾病中不同但重叠的兴趣。本次会议的具体目标是召集38-46名涵盖关键基础科学和临床主题的领先专家，共有150名与会者，为期五天。会议将分为9个部分，包括第一天的开幕式，其中包括2个主题演讲，然后是8个部分，每个部分侧重于一个特定的疾病领域。在会议剩余的4天里，每天将开始另外4场主题演讲，就当天会议相关的主题提供高层次的介绍。主题演讲将由Ada Yonath博士、Paul Schimmel博士、Nahum Sonenberg博士和Jonathan Weissman博士主讲，另有两个讲座将宣布。其中，Yonath博士是诺贝尔奖获得者，以其在核糖体结构和功能方面的开创性工作而闻名; Schimmel博士是tRNA合成酶领域最著名的科学家，也是一位企业家，通过他创立的许多成功的生物技术公司将基础科学转化为治疗方法。此外，四个下午的海报会议将使所有与会者都能为会议作出贡献。与所有戈登会议一样，年轻的调查人员、妇女和少数民族将有许多机会与该领域的高级领导人互动。为 作为翻译领域的第一次以疾病为重点的会议，这次会议将极大地影响我们对许多重要疾病的理解，如自身免疫性肌炎、癌症、神经变性、糖尿病、贫血、病毒和细菌感染及其治疗。