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Full Project 1: LSR Alters Metabolic Signaling to Drive Aggressive Breast Cancer Behaviors

完整项目 1：LSR 改变代谢信号以驱动侵袭性乳腺癌行为

基本信息

批准号：
9050348
负责人：
Jodie Michelle Fleming
金额：
$ 18.9万
依托单位：
NORTH CAROLINA CENTRAL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-29 至 2020-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9050348
关键词：
Address Advanced Malignant Neoplasm African American Anabolism Behavior Binding Bioenergetics Biological Biological Assay Breast Cancer Cell Cancer Biology Caucasians Cell division Cell physiology Cholesterol Chronic Clinical Collaborations Community Outreach Comprehensive Cancer Center Cytoplasmic Tail Data Diagnosis Diet Disease Distant Metastasis Education Education and Outreach Educational process of instructing Endocytosis Energy-Generating Resources Environment Event Faculty Fatty acid glycerol esters Foundations Funding Gene Chips Genes Genomics Glycogen Goals Guanosine Triphosphate Phosphohydrolases Health Sciences Hepatic Histopathology In Vitro Incidence Institution Lead Leptin Link Lipids Lipolysis Lipoprotein Receptor Lipoproteins Malignant - descriptor Malignant Neoplasms Mammary Neoplasms Measures Mediating Membrane Membrane Lipids Mentorship Metabolic Metabolic syndrome Metabolism Minority Molecular Morbidity - disease rate Mus Neoplasm Metastasis North Carolina Nuclear Obesity Observational Study Outcome Outreach Research Pathway interactions Patients Phenotype Pilot Projects Population Population Sciences Positioning Attribute Prevalence Property Proteins Public Health Race Recurrence Regulation Research Research Infrastructure Research Training Resistance Resources Role Scientist Signal Pathway Signal Transduction Signaling Molecule Statistical Models Students Testing Tight Junctions Tumor Subtype UNC Lineberger Comprehensive Cancer Center Universities Variant Woman Work Xenograft procedure anticancer research base cancer education cancer health disparity cancer stem cell career caucasian American cell behavior community intervention feeding glucose uptake graduate student health disparity health equity improved in vivo insight interest lipid metabolism lipid transport malignant breast neoplasm meetings metabolomics minority health mortality novel overexpression population based racial disparity receptor expression receptor function research study response rho rho GTP-Binding Proteins therapeutic development tumor tumor progression tumorigenesis tumorigenic undergraduate student uptake

项目摘要

The North Carolina Central University (NCCU) and the Lineberger Comprehensive Cancer Center (LCCC) at the University of North Carolina Chapel Hill (UNC-CH) will continue their effective and mutually beneficial partnership focusing on African-American health disparities. During the past 13 years NCI funding has firmly established the Partnership building on complementary institutional strengths, conducting molecular and population-based cancer research and training of junior faculty and students. This Comprehensive Partnership to Advance Cancer Health Equity (CPACHE) application builds upon the foundation already established through the previous U54 funding to meet the challenge of disparities in cancer incidence and mortality in North Carolina and the US through cancer research, education and community outreach. Our goals are to: (1) strengthen cancer research capacity at NCCU providing NCCU scientists mentorship and collaborative opportunities to compete for NCI grantst; (2) enrich the capacity of NCCU and LCCC to further explore mechanisms underlying the disproportionate incidence of cancer mortality and morbidity between African Americans and Caucasian Americans, using both molecular and population-based approaches; (3) increase the number of NCCU scientists focused on cancer research as well as the education of minority undergraduate and graduate students in cancer research; (4) increase the faculty at the UNC LCCC focused on minority disparities research; and (5) create long-term collaborations between basic, public health, and translational scientists from NCCU and UNC LCCC. The strengths of each institution are uniquely positioned to overcome the weaknesses found in the other to achieve these priorities. Specific collaborative components of the proposal include: Two full and one pilot projects in community intervention and population science, one full and one pilot project in basic/translational cancer research in diseases with a higher incidence in African Americans, and 3 cores: Outreach, Research Education, and Histopathology. The partnership combines the expertise and resources of LCCC in population/public health sciences emphasizing disparities in North Carolina, genomics, cancer biology and cancer education and NCCU’s demonstrated interest and facilty with minority health disparities research particularly in Durham NC, the state-funded NCCU units that allow faculty release from teaching and the emphasis on reaching minority populations and developing the careers of , faculty and students. These complementary institutional strengths will assure that the Partnership builds the infrastructure necessary for a lasting collaborative research, effective community outreach and a substantial contribution to our understanding of minority disparities..

北卡罗来纳州中央大学（NCCU）和Lineberger综合大学北卡罗来纳州查佩尔山大学（UNC-CH）的癌症中心（LCCC）将继续他们的有效和互利的伙伴关系，重点是非洲裔美国人的健康差距。在过去的13年里，国家癌症研究所的资助已经牢固地建立了伙伴关系，利用互补的机构优势，开展基于分子和人口的癌症研究和初级教师和学生的培训。这一全面伙伴关系，先进的癌症健康公平（CPACHE）应用程序建立在基础上已经通过之前的U54基金建立，以应对癌症差异的挑战北卡罗来纳州和美国通过癌症研究、教育和社区外展我们的目标是：（1）加强癌症研究的能力，提供NCCU科学家指导和合作机会，以竞争NCI （2）加强国家儿童保育股和地方儿童保育中心的能力，以进一步探讨非裔美国人之间癌症死亡率和发病率不成比例和高加索美国人，使用分子和人口为基础的方法;（3）增加NCCU科学家的数量，专注于癌症研究以及教育少数民族大学生和研究生在癌症研究;（4）增加教师在 LCCC专注于少数民族差异研究;（5）建立长期合作关系来自NCCU和CALLCCC的基础，公共卫生和转化科学家之间。的每个机构的优势是独特的定位，以克服在另一方面，实现这些优先事项。该提案的具体合作内容包括：社区干预和人口科学方面的两个全面项目和一个试点项目，一个关于癌症发病率较高的疾病的基础/转化癌症研究的试点项目，非裔美国人，和3个核心：外展，研究教育和历史学。的伙伴关系结合了LCCC在人口/公共卫生科学方面的专业知识和资源强调北卡罗来纳州、基因组学、癌症生物学和癌症教育的差异， NCCU对少数民族健康差异研究表现出的兴趣和能力，在北卡罗来纳州的达勒姆，国家资助的NCCU单位允许教师从教学中解脱出来，重点是接触少数民族人口和发展教师和学生的职业生涯。这些相辅相成的体制优势将确保伙伴关系建立起持久的合作研究所需的基础设施，有效的社区推广，对我们理解少数民族的差异做出了重大贡献。