Full Project 1: LSR Alters Metabolic Signaling to Drive Aggressive Breast Cancer Behaviors
完整项目 1:LSR 改变代谢信号以驱动侵袭性乳腺癌行为
基本信息
- 批准号:9050348
- 负责人:
- 金额:$ 18.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-09-29 至 2020-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdvanced Malignant NeoplasmAfrican AmericanAnabolismBehaviorBindingBioenergeticsBiologicalBiological AssayBreast Cancer CellCancer BiologyCaucasiansCell divisionCell physiologyCholesterolChronicClinicalCollaborationsCommunity OutreachComprehensive Cancer CenterCytoplasmic TailDataDiagnosisDietDiseaseDistant MetastasisEducationEducation and OutreachEducational process of instructingEndocytosisEnergy-Generating ResourcesEnvironmentEventFacultyFatty acid glycerol estersFoundationsFundingGene ChipsGenesGenomicsGlycogenGoalsGuanosine Triphosphate PhosphohydrolasesHealth SciencesHepaticHistopathologyIn VitroIncidenceInstitutionLeadLeptinLinkLipidsLipolysisLipoprotein ReceptorLipoproteinsMalignant - descriptorMalignant NeoplasmsMammary NeoplasmsMeasuresMediatingMembraneMembrane LipidsMentorshipMetabolicMetabolic syndromeMetabolismMinorityMolecularMorbidity - disease rateMusNeoplasm MetastasisNorth CarolinaNuclearObesityObservational StudyOutcomeOutreach ResearchPathway interactionsPatientsPhenotypePilot ProjectsPopulationPopulation SciencesPositioning AttributePrevalencePropertyProteinsPublic HealthRaceRecurrenceRegulationResearchResearch InfrastructureResearch TrainingResistanceResourcesRoleScientistSignal PathwaySignal TransductionSignaling MoleculeStatistical ModelsStudentsTestingTight JunctionsTumor SubtypeUNC Lineberger Comprehensive Cancer CenterUniversitiesVariantWomanWorkXenograft procedureanticancer researchbasecancer educationcancer health disparitycancer stem cellcareercaucasian Americancell behaviorcommunity interventionfeedingglucose uptakegraduate studenthealth disparityhealth equityimprovedin vivoinsightinterestlipid metabolismlipid transportmalignant breast neoplasmmeetingsmetabolomicsminority healthmortalitynoveloverexpressionpopulation basedracial disparityreceptor expressionreceptor functionresearch studyresponserhorho GTP-Binding Proteinstherapeutic developmenttumortumor progressiontumorigenesistumorigenicundergraduate studentuptake
项目摘要
The North Carolina Central University (NCCU) and the Lineberger Comprehensive
Cancer Center (LCCC) at the University of North Carolina Chapel Hill (UNC-CH) will continue
their effective and mutually beneficial partnership focusing on African-American health
disparities. During the past 13 years NCI funding has firmly established the Partnership
building on complementary institutional strengths, conducting molecular and population-based
cancer research and training of junior faculty and students. This Comprehensive Partnership to
Advance Cancer Health Equity (CPACHE) application builds upon the foundation already
established through the previous U54 funding to meet the challenge of disparities in cancer
incidence and mortality in North Carolina and the US through cancer research, education and
community outreach. Our goals are to: (1) strengthen cancer research capacity at NCCU
providing NCCU scientists mentorship and collaborative opportunities to compete for NCI
grantst; (2) enrich the capacity of NCCU and LCCC to further explore mechanisms underlying
the disproportionate incidence of cancer mortality and morbidity between African Americans
and Caucasian Americans, using both molecular and population-based approaches; (3)
increase the number of NCCU scientists focused on cancer research as well as the education of
minority undergraduate and graduate students in cancer research; (4) increase the faculty at the
UNC LCCC focused on minority disparities research; and (5) create long-term collaborations
between basic, public health, and translational scientists from NCCU and UNC LCCC. The
strengths of each institution are uniquely positioned to overcome the weaknesses found in the
other to achieve these priorities. Specific collaborative components of the proposal include:
Two full and one pilot projects in community intervention and population science, one full and
one pilot project in basic/translational cancer research in diseases with a higher incidence in
African Americans, and 3 cores: Outreach, Research Education, and Histopathology. The
partnership combines the expertise and resources of LCCC in population/public health sciences
emphasizing disparities in North Carolina, genomics, cancer biology and cancer education and
NCCU’s demonstrated interest and facilty with minority health disparities research particularly
in Durham NC, the state-funded NCCU units that allow faculty release from teaching and the
emphasis on reaching minority populations and developing the careers of , faculty and students.
These complementary institutional strengths will assure that the Partnership builds the
infrastructure necessary for a lasting collaborative research, effective community outreach and
a substantial contribution to our understanding of minority disparities..
北卡罗莱纳中央大学(NCCU)和莱恩伯格综合学校
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jodie Michelle Fleming其他文献
Jodie Michelle Fleming的其他文献
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{{ truncateString('Jodie Michelle Fleming', 18)}}的其他基金
Project 2 - Mechanisms linking Cancer Disparities and Metabolic Status
项目 2 - 连接癌症差异和代谢状态的机制
- 批准号:
10204739 - 财政年份:2017
- 资助金额:
$ 18.9万 - 项目类别:
Project 2 - Mechanisms linking Cancer Disparities and Metabolic Status
项目 2 - 连接癌症差异和代谢状态的机制
- 批准号:
9977714 - 财政年份:2017
- 资助金额:
$ 18.9万 - 项目类别:
HGF signaling in African-American and Basal-like Breast Cancer
非裔美国人乳腺癌和基底样乳腺癌中的 HGF 信号传导
- 批准号:
8726349 - 财政年份:2013
- 资助金额:
$ 18.9万 - 项目类别:
HGF signaling in African-American and Basal-like Breast Cancer
非裔美国人乳腺癌和基底样乳腺癌中的 HGF 信号传导
- 批准号:
8491064 - 财政年份:2013
- 资助金额:
$ 18.9万 - 项目类别:
Development of a novel targeted-therapy for treatment of basal-like breast cancer
开发治疗基底样乳腺癌的新型靶向疗法
- 批准号:
8337127 - 财政年份:2012
- 资助金额:
$ 18.9万 - 项目类别:
Development of a novel targeted-therapy for treatment of basal-like breast cancer
开发治疗基底样乳腺癌的新型靶向疗法
- 批准号:
8731643 - 财政年份:2012
- 资助金额:
$ 18.9万 - 项目类别:
Development of a novel targeted-therapy for treatment of basal-like breast cancer
开发治疗基底样乳腺癌的新型靶向疗法
- 批准号:
8551659 - 财政年份:2012
- 资助金额:
$ 18.9万 - 项目类别:
Project 2 - Mechanisms linking Cancer Disparities and Metabolic Status
项目 2 - 连接癌症差异和代谢状态的机制
- 批准号:
9750532 - 财政年份:
- 资助金额:
$ 18.9万 - 项目类别:
Full Project 4: Molecular Pathways to Breast Cancer Mortality among African American and White Women
完整项目 4:非裔美国和白人女性乳腺癌死亡率的分子途径
- 批准号:
10004337 - 财政年份:
- 资助金额:
$ 18.9万 - 项目类别:
Full Project 1: LSR Alters Metabolic Signaling to Drive Aggressive Breast Cancer Behaviors
完整项目 1:LSR 改变代谢信号以驱动侵袭性乳腺癌行为
- 批准号:
9152333 - 财政年份:
- 资助金额:
$ 18.9万 - 项目类别:














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