Full Project 1: LSR Alters Metabolic Signaling to Drive Aggressive Breast Cancer Behaviors
完整项目 1:LSR 改变代谢信号以驱动侵袭性乳腺癌行为
基本信息
- 批准号:9050348
- 负责人:
- 金额:$ 18.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-09-29 至 2020-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdvanced Malignant NeoplasmAfrican AmericanAnabolismBehaviorBindingBioenergeticsBiologicalBiological AssayBreast Cancer CellCancer BiologyCaucasiansCell divisionCell physiologyCholesterolChronicClinicalCollaborationsCommunity OutreachComprehensive Cancer CenterCytoplasmic TailDataDiagnosisDietDiseaseDistant MetastasisEducationEducation and OutreachEducational process of instructingEndocytosisEnergy-Generating ResourcesEnvironmentEventFacultyFatty acid glycerol estersFoundationsFundingGene ChipsGenesGenomicsGlycogenGoalsGuanosine Triphosphate PhosphohydrolasesHealth SciencesHepaticHistopathologyIn VitroIncidenceInstitutionLeadLeptinLinkLipidsLipolysisLipoprotein ReceptorLipoproteinsMalignant - descriptorMalignant NeoplasmsMammary NeoplasmsMeasuresMediatingMembraneMembrane LipidsMentorshipMetabolicMetabolic syndromeMetabolismMinorityMolecularMorbidity - disease rateMusNeoplasm MetastasisNorth CarolinaNuclearObesityObservational StudyOutcomeOutreach ResearchPathway interactionsPatientsPhenotypePilot ProjectsPopulationPopulation SciencesPositioning AttributePrevalencePropertyProteinsPublic HealthRaceRecurrenceRegulationResearchResearch InfrastructureResearch TrainingResistanceResourcesRoleScientistSignal PathwaySignal TransductionSignaling MoleculeStatistical ModelsStudentsTestingTight JunctionsTumor SubtypeUNC Lineberger Comprehensive Cancer CenterUniversitiesVariantWomanWorkXenograft procedureanticancer researchbasecancer educationcancer health disparitycancer stem cellcareercaucasian Americancell behaviorcommunity interventionfeedingglucose uptakegraduate studenthealth disparityhealth equityimprovedin vivoinsightinterestlipid metabolismlipid transportmalignant breast neoplasmmeetingsmetabolomicsminority healthmortalitynoveloverexpressionpopulation basedracial disparityreceptor expressionreceptor functionresearch studyresponserhorho GTP-Binding Proteinstherapeutic developmenttumortumor progressiontumorigenesistumorigenicundergraduate studentuptake
项目摘要
The North Carolina Central University (NCCU) and the Lineberger Comprehensive
Cancer Center (LCCC) at the University of North Carolina Chapel Hill (UNC-CH) will continue
their effective and mutually beneficial partnership focusing on African-American health
disparities. During the past 13 years NCI funding has firmly established the Partnership
building on complementary institutional strengths, conducting molecular and population-based
cancer research and training of junior faculty and students. This Comprehensive Partnership to
Advance Cancer Health Equity (CPACHE) application builds upon the foundation already
established through the previous U54 funding to meet the challenge of disparities in cancer
incidence and mortality in North Carolina and the US through cancer research, education and
community outreach. Our goals are to: (1) strengthen cancer research capacity at NCCU
providing NCCU scientists mentorship and collaborative opportunities to compete for NCI
grantst; (2) enrich the capacity of NCCU and LCCC to further explore mechanisms underlying
the disproportionate incidence of cancer mortality and morbidity between African Americans
and Caucasian Americans, using both molecular and population-based approaches; (3)
increase the number of NCCU scientists focused on cancer research as well as the education of
minority undergraduate and graduate students in cancer research; (4) increase the faculty at the
UNC LCCC focused on minority disparities research; and (5) create long-term collaborations
between basic, public health, and translational scientists from NCCU and UNC LCCC. The
strengths of each institution are uniquely positioned to overcome the weaknesses found in the
other to achieve these priorities. Specific collaborative components of the proposal include:
Two full and one pilot projects in community intervention and population science, one full and
one pilot project in basic/translational cancer research in diseases with a higher incidence in
African Americans, and 3 cores: Outreach, Research Education, and Histopathology. The
partnership combines the expertise and resources of LCCC in population/public health sciences
emphasizing disparities in North Carolina, genomics, cancer biology and cancer education and
NCCU’s demonstrated interest and facilty with minority health disparities research particularly
in Durham NC, the state-funded NCCU units that allow faculty release from teaching and the
emphasis on reaching minority populations and developing the careers of , faculty and students.
These complementary institutional strengths will assure that the Partnership builds the
infrastructure necessary for a lasting collaborative research, effective community outreach and
a substantial contribution to our understanding of minority disparities..
北卡罗来纳州中央大学(NCCU)和Lineberger综合大学
北卡罗来纳州查佩尔山大学(UNC-CH)的癌症中心(LCCC)将继续
他们的有效和互利的伙伴关系,重点是非洲裔美国人的健康
差距。在过去的13年里,国家癌症研究所的资助已经牢固地建立了伙伴关系,
利用互补的机构优势,开展基于分子和人口的
癌症研究和初级教师和学生的培训。这一全面伙伴关系,
先进的癌症健康公平(CPACHE)应用程序建立在基础上已经
通过之前的U54基金建立,以应对癌症差异的挑战
北卡罗来纳州和美国通过癌症研究、教育和
社区外展我们的目标是:(1)加强癌症研究的能力,
提供NCCU科学家指导和合作机会,以竞争NCI
(2)加强国家儿童保育股和地方儿童保育中心的能力,以进一步探讨
非裔美国人之间癌症死亡率和发病率不成比例
和高加索美国人,使用分子和人口为基础的方法;(3)
增加NCCU科学家的数量,专注于癌症研究以及教育
少数民族大学生和研究生在癌症研究;(4)增加教师在
LCCC专注于少数民族差异研究;(5)建立长期合作关系
来自NCCU和CALLCCC的基础,公共卫生和转化科学家之间。的
每个机构的优势是独特的定位,以克服在
另一方面,实现这些优先事项。该提案的具体合作内容包括:
社区干预和人口科学方面的两个全面项目和一个试点项目,
一个关于癌症发病率较高的疾病的基础/转化癌症研究的试点项目,
非裔美国人,和3个核心:外展,研究教育和历史学。的
伙伴关系结合了LCCC在人口/公共卫生科学方面的专业知识和资源
强调北卡罗来纳州、基因组学、癌症生物学和癌症教育的差异,
NCCU对少数民族健康差异研究表现出的兴趣和能力,
在北卡罗来纳州的达勒姆,国家资助的NCCU单位允许教师从教学中解脱出来,
重点是接触少数民族人口和发展教师和学生的职业生涯。
这些相辅相成的体制优势将确保伙伴关系建立起
持久的合作研究所需的基础设施,有效的社区推广,
对我们理解少数民族的差异做出了重大贡献。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jodie Michelle Fleming其他文献
Jodie Michelle Fleming的其他文献
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{{ truncateString('Jodie Michelle Fleming', 18)}}的其他基金
Project 2 - Mechanisms linking Cancer Disparities and Metabolic Status
项目 2 - 连接癌症差异和代谢状态的机制
- 批准号:
10204739 - 财政年份:2017
- 资助金额:
$ 18.9万 - 项目类别:
Project 2 - Mechanisms linking Cancer Disparities and Metabolic Status
项目 2 - 连接癌症差异和代谢状态的机制
- 批准号:
9977714 - 财政年份:2017
- 资助金额:
$ 18.9万 - 项目类别:
HGF signaling in African-American and Basal-like Breast Cancer
非裔美国人乳腺癌和基底样乳腺癌中的 HGF 信号传导
- 批准号:
8726349 - 财政年份:2013
- 资助金额:
$ 18.9万 - 项目类别:
HGF signaling in African-American and Basal-like Breast Cancer
非裔美国人乳腺癌和基底样乳腺癌中的 HGF 信号传导
- 批准号:
8491064 - 财政年份:2013
- 资助金额:
$ 18.9万 - 项目类别:
Development of a novel targeted-therapy for treatment of basal-like breast cancer
开发治疗基底样乳腺癌的新型靶向疗法
- 批准号:
8337127 - 财政年份:2012
- 资助金额:
$ 18.9万 - 项目类别:
Development of a novel targeted-therapy for treatment of basal-like breast cancer
开发治疗基底样乳腺癌的新型靶向疗法
- 批准号:
8731643 - 财政年份:2012
- 资助金额:
$ 18.9万 - 项目类别:
Development of a novel targeted-therapy for treatment of basal-like breast cancer
开发治疗基底样乳腺癌的新型靶向疗法
- 批准号:
8551659 - 财政年份:2012
- 资助金额:
$ 18.9万 - 项目类别:
Project 2 - Mechanisms linking Cancer Disparities and Metabolic Status
项目 2 - 连接癌症差异和代谢状态的机制
- 批准号:
9750532 - 财政年份:
- 资助金额:
$ 18.9万 - 项目类别:
Full Project 4: Molecular Pathways to Breast Cancer Mortality among African American and White Women
完整项目 4:非裔美国和白人女性乳腺癌死亡率的分子途径
- 批准号:
10004337 - 财政年份:
- 资助金额:
$ 18.9万 - 项目类别:
Full Project 1: LSR Alters Metabolic Signaling to Drive Aggressive Breast Cancer Behaviors
完整项目 1:LSR 改变代谢信号以驱动侵袭性乳腺癌行为
- 批准号:
9152333 - 财政年份:
- 资助金额:
$ 18.9万 - 项目类别:














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