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Full Project 1: LSR Alters Metabolic Signaling to Drive Aggressive Breast Cancer Behaviors

完整项目 1：LSR 改变代谢信号以驱动侵袭性乳腺癌行为

基本信息

批准号：
9050348
负责人：
Jodie Michelle Fleming
金额：
$ 18.9万
依托单位：
NORTH CAROLINA CENTRAL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-29 至 2020-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9050348
关键词：
Address Advanced Malignant Neoplasm African American Anabolism Behavior Binding Bioenergetics Biological Biological Assay Breast Cancer Cell Cancer Biology Caucasians Cell division Cell physiology Cholesterol Chronic Clinical Collaborations Community Outreach Comprehensive Cancer Center Cytoplasmic Tail Data Diagnosis Diet Disease Distant Metastasis Education Education and Outreach Educational process of instructing Endocytosis Energy-Generating Resources Environment Event Faculty Fatty acid glycerol esters Foundations Funding Gene Chips Genes Genomics Glycogen Goals Guanosine Triphosphate Phosphohydrolases Health Sciences Hepatic Histopathology In Vitro Incidence Institution Lead Leptin Link Lipids Lipolysis Lipoprotein Receptor Lipoproteins Malignant - descriptor Malignant Neoplasms Mammary Neoplasms Measures Mediating Membrane Membrane Lipids Mentorship Metabolic Metabolic syndrome Metabolism Minority Molecular Morbidity - disease rate Mus Neoplasm Metastasis North Carolina Nuclear Obesity Observational Study Outcome Outreach Research Pathway interactions Patients Phenotype Pilot Projects Population Population Sciences Positioning Attribute Prevalence Property Proteins Public Health Race Recurrence Regulation Research Research Infrastructure Research Training Resistance Resources Role Scientist Signal Pathway Signal Transduction Signaling Molecule Statistical Models Students Testing Tight Junctions Tumor Subtype UNC Lineberger Comprehensive Cancer Center Universities Variant Woman Work Xenograft procedure anticancer research base cancer education cancer health disparity cancer stem cell career caucasian American cell behavior community intervention feeding glucose uptake graduate student health disparity health equity improved in vivo insight interest lipid metabolism lipid transport malignant breast neoplasm meetings metabolomics minority health mortality novel overexpression population based racial disparity receptor expression receptor function research study response rho rho GTP-Binding Proteins therapeutic development tumor tumor progression tumorigenesis tumorigenic undergraduate student uptake

项目摘要

The North Carolina Central University (NCCU) and the Lineberger Comprehensive Cancer Center (LCCC) at the University of North Carolina Chapel Hill (UNC-CH) will continue their effective and mutually beneficial partnership focusing on African-American health disparities. During the past 13 years NCI funding has firmly established the Partnership building on complementary institutional strengths, conducting molecular and population-based cancer research and training of junior faculty and students. This Comprehensive Partnership to Advance Cancer Health Equity (CPACHE) application builds upon the foundation already established through the previous U54 funding to meet the challenge of disparities in cancer incidence and mortality in North Carolina and the US through cancer research, education and community outreach. Our goals are to: (1) strengthen cancer research capacity at NCCU providing NCCU scientists mentorship and collaborative opportunities to compete for NCI grantst; (2) enrich the capacity of NCCU and LCCC to further explore mechanisms underlying the disproportionate incidence of cancer mortality and morbidity between African Americans and Caucasian Americans, using both molecular and population-based approaches; (3) increase the number of NCCU scientists focused on cancer research as well as the education of minority undergraduate and graduate students in cancer research; (4) increase the faculty at the UNC LCCC focused on minority disparities research; and (5) create long-term collaborations between basic, public health, and translational scientists from NCCU and UNC LCCC. The strengths of each institution are uniquely positioned to overcome the weaknesses found in the other to achieve these priorities. Specific collaborative components of the proposal include: Two full and one pilot projects in community intervention and population science, one full and one pilot project in basic/translational cancer research in diseases with a higher incidence in African Americans, and 3 cores: Outreach, Research Education, and Histopathology. The partnership combines the expertise and resources of LCCC in population/public health sciences emphasizing disparities in North Carolina, genomics, cancer biology and cancer education and NCCU’s demonstrated interest and facilty with minority health disparities research particularly in Durham NC, the state-funded NCCU units that allow faculty release from teaching and the emphasis on reaching minority populations and developing the careers of , faculty and students. These complementary institutional strengths will assure that the Partnership builds the infrastructure necessary for a lasting collaborative research, effective community outreach and a substantial contribution to our understanding of minority disparities..

北卡罗莱纳中央大学（NCCU）和莱恩伯格综合学校