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Development of A Novel Anti-Hyperglycemic Agent

Development of A Novel Anti-Hyperglycemic Agent
新型抗高血糖药的研制
批准号:
7784494
负责人:
Zhaoping Li
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-04-01 至 2012-09-30
关键词:
Adverse effectsAdverse eventAgreementAlzheimer&aposs DiseaseAmino AcidsAnimal ModelAnimalsAsiansBloodBlood GlucoseBone DensityBrainCardiovascular systemCause of DeathCell membraneCellsCenters for Disease Control and Prevention (U.S.)ChemistryChronic DiseaseClinicalClinical TrialsComplexCopperCountryCytosolDefectDevelopmentDiabetes MellitusDiabetes preventionDipeptidesDiseaseDoseDouble-Blind MethodDropsEnvironmental Risk FactorEnzyme GeneEnzymesEuropeanEventExpenditureFDA approvedFastingFutureGelGenesGeneticGenetic PolymorphismGlucagonGlucoseGlucose IntoleranceGlucose TransporterGlucose tolerance testGlycosylated hemoglobin AHealthHealthcareHematologyHepaticHigh PrevalenceHourHumanHyperglycemiaHypoglycemiaHypoglycemic AgentsImpairmentInjection of therapeutic agentInpatientsInsulinInsulin ReceptorInsulin ResistanceInsulinaseIntakeIntestinesKidneyLeadLegal patentLeptinLiteratureLiverLiver FailureMarketingMediatingMedicalMedical centerMetforminMolecularMuscleMutationNational Health and Nutrition Examination SurveyNauseaNon-Insulin-Dependent Diabetes MellitusObesityOralOral AdministrationOutcomeOutcome StudyOutpatientsPatientsPeptide HydrolasesPeptidesPeripheralPharmaceutical PreparationsPharmacy facilityPhasePhase I Clinical TrialsPioglitazonePlacebo ControlPlacebosPlasmaPlayPopulationPreventionProcessProteinsRandomizedRattusReceptor SignalingRecruitment ActivityRegimenReportingResearchResearch DesignRiskRoleSLC2A1 geneSafetyServicesSevere Adverse EventSignal TransductionStomachSulfonylurea CompoundsSymptomsTherapeutic AgentsThyroid Function TestsTissuesUnited StatesUrineVeteransVisitVomitingZincZinc deficiencyabsorptionadiponectinanalogbasebrain tissuecapsulecommercializationcostdiabeticdiabetic patientdiet and exerciseeffective therapyexperiencefasting plasma glucosefour-arm studyfunctional disabilityglucogenesisglucose metabolismglucose outputglucose uptakeglycemic controlhistidylprolineimprovedinhibitor/antagonistinsulin sensitivityinsulin signalingnoveloral glucose toleranceprimary outcomepublic health relevancereceptor recyclingrosiglitazonesecondary outcomevolunteerweek trial

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Development of A Novel Anti-Hyperglycemic Agent
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