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Statin modulation of immunotherapy for Alzheimer disease

Statin modulation of immunotherapy for Alzheimer disease
他汀类药物调节阿尔茨海默病免疫疗法
批准号：
7780445
负责人：
Jun Tan
金额：
$0.0万
依托单位：
JAMES A. HALEY VA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-04-01 至 2012-09-30
来源：
https://reporter.nih.gov/project-details/7780445
关键词：
AccountingAdverse effectsAgeAgonistAlzheimer like pathologyAlzheimer&aposs DiseaseAlzheimer&aposs disease modelAmino AcidsAmyloid beta-ProteinAnti-Inflammatory AgentsAnti-inflammatoryAntibodiesAnticholesteremic AgentsAntigen PresentationAntigen-Presenting CellsAntigensAttenuatedBehaviorBehavioralBiochemicalBloodBrainCell surfaceCerebral Amyloid AngiopathyCerebrumChemicalsChronicClinical TrialsCognitionCognitive deficitsConflict (Psychology)Cytokine SignalingCytotoxic T-LymphocytesDataDementiaDepositionDevelopmentDirect CostsDiseaseElderlyEncephalitisExcisionFacilities and Administrative CostsFc ReceptorFlow CytometryFrequenciesFutureHealthHealth Care CostsHealthcareImmunoglobulin GImmunosuppressionImmunotherapyImpairmentIn VitroIndividualInflammationInflammatoryInflammatory ResponseInterferonsInterleukin-10Interleukin-4Interleukin-6Knockout MiceLeadLengthLifeLigationLovastatinMeasuresMediatingMemoryMemory impairmentMicrogliaMiddle EastMusPathologyPathway interactionsPatientsPeptidesPeripheralPhagocytosisPhenotypePhosphorylationPreparationPrevalenceProductionPropertyRecoveryRegulationReportingResearchReverse Transcriptase Polymerase Chain ReactionRiskRoleSTAT1 geneSenile PlaquesShort-Term MemorySignal PathwaySignal TransductionTNFRSF5 geneTNFSF5 geneTestingTg2576TherapeuticTherapeutic EffectTherapy Clinical TrialsTimeTransforming Growth Factor betaTransgenic MiceTumor Necrosis Factor-alphaVaccinatedVaccinationVaccinesValidationVeteransWestern Blottingabstractingagedaging populationbasebeta amyloid pathologycrosslinkcytokinedesignexperienceextracellularhuman TNF proteinimprovedin vitro testingin vivoinhibitor/antagonistmouse modelpeptide Apublic health relevanceresponsesocioeconomicssuccessuptakevaccination strategy

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