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p75NTR-Ceramide Signaling in Alzheimer?s Disease

p75NTR-Ceramide Signaling in Alzheimer?s Disease
阿尔茨海默病中的 p75NTR-神经酰胺信号转导
批准号：
8195635
负责人：
Luigi Puglielli
金额：
$0.0万
依托单位：
WM S. MIDDLETON MEMORIAL VETERANS HOSP
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-04-01 至 2013-03-31
来源：
https://reporter.nih.gov/project-details/8195635
关键词：
AddressAffectAffinityAgeAgingAging-Related ProcessAlzheimer&aposs DiseaseAmericanAmyloidAmyloid beta-ProteinAnimal ModelAnimalsAntisense OligonucleotidesBindingBiochemicalBiochemical GeneticsBrainCell LineCeramidesCessation of lifeClinicalCognitiveDementiaDevelopmentDiseaseDown-RegulationEducationElderlyEngineeringEventFundingGenerationsGeneticGoalsHealthcareHospitalsHumanIRS2 geneIn VitroIndividualInsulin-Like-Growth Factor I ReceptorKnowledgeLearningLeftLifeLinkLipidsMediatingMemory impairmentMetabolismMissionModelingMolecularMusNGFR ProteinNational Institute of Neurological Disorders and StrokeNeuronsOutputPTEN genePathogenesisPathologyPathway interactionsPatternPhenotypePlayPopulationPreventionProductionProtein IsoformsPublishingQuality of CareReceptor SignalingRegulationReportingResearchRisk FactorsRoleSecond Messenger SystemsSenile PlaquesSignal PathwaySignal TransductionSmall Interfering RNASphingomyelinaseStressStudy SectionStudy modelsSystemTestingTimeTransfectionTransgenesTransgenic AnimalsTransgenic MiceVeteransWorkage effectagedaging brainbeta-site APP cleaving enzyme 1cognitive functioncost effectivehuman old age (65+)improvedin vitro Assayinhibitor/antagonistinterestjuvenile animalmanumycinmutantneuroblastoma cellneuropathologyneurotrophic factornormal agingnovelprogramspublic health relevancesecond messengertau Proteinstau phosphorylationtherapeutic targettool

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ATase1 and ATase2, proteostasis, and neurological diseases
  • 批准号：
    10554962
  • 项目类别：
  • 资助金额：
    $30.03万
  • 财政年份：
    2023
  • 负责人：
    Luigi Puglielli
  • 依托单位：
    UNIVERSITY OF WISCONSIN-MADISON
Novel mechanisms for Alzheimer disease prevention and or treatment
Novel mechanisms for Alzheimer disease prevention and or treatment
Novel mechanisms for Alzheimer disease prevention and or treatment
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