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Calcium dynamics in embryonic-stem-cell derived cardiac myocytes.

Calcium dynamics in embryonic-stem-cell derived cardiac myocytes.
胚胎干细胞衍生的心肌细胞中的钙动态。
批准号:
8156758
负责人:
Michael Stern
金额:
$39.17万
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依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
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英文摘要
Cardiac myocytes were differentiated in vitro from cultured embryonic stem cells derived from mice. The cultured cells displayed spontaneous beating. Like adult pacemaker cells, the embryonic stem cell derived cells were found to display wave-like spontaneous calcium oscillations which entrain with whole-cell action potentials by means of sodium-calcium exchange. As in sino-atrial node cells, these oscillations were promoted by elevation of intracellular cyclic AMP. This suggests that cells engineered to have constitutively high cAMP levels could form robust pacemakers.
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Darwinian Evolution of Virtual Organisms
  • 批准号:
    9551848
  • 项目类别:
  • 资助金额:
    $2.69万
  • 财政年份:
    --
  • 负责人:
    Michael Stern
  • 依托单位:
Stochastic Simulation Of Excitation-contraction Coupling
  • 批准号:
    8335938
  • 项目类别:
  • 资助金额:
    $37.73万
  • 财政年份:
    --
  • 负责人:
    Michael Stern
  • 依托单位:
Calcium dynamics in embryonic-stem-cell derived cardiac myocytes.
  • 批准号:
    7963896
  • 项目类别:
  • 资助金额:
    $40.66万
  • 财政年份:
    --
  • 负责人:
    Michael Stern
  • 依托单位:
Stochastic Simulation Of Excitation-contraction Coupling
  • 批准号:
    9549389
  • 项目类别:
  • 资助金额:
    $86.18万
  • 财政年份:
    --
  • 负责人:
    Michael Stern
  • 依托单位:
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