Stochastic Simulation Of Excitation-contraction Coupling

工作概要正在进行全三维模型的软件开发。 2D网格模型已被修订，以包括全细胞钙平衡的详细平衡。 这个模型已经完全用编译后的Java重新编码，并在本地集群的所有48个处理器上并行运行，效率超过70%。 这使得有可能探索参数，并确定几个不同的新制度的传播有关的起搏功能的SR钙释放sin 0-心房结细胞。 已经进行了大量的模拟作为调节心率的关键参数的函数。 该模型成功地expalins的各种制度的本地和全球的钙释放和这些制度之间的过渡作为一个功能的释放电流。 这些结果与自主神经系统如何调节心率的新模型一致。 一份出版物目前正在接受期刊评审。

SUMMARY OF WORK Software development on the full 3D model is proceding. The 2D grid model has been revised to include detailed balancing of whole-cell calcium balance. This model has been entirely recoded in compiled Java and spun out to run concurrently on all 48 processors of our local cluster with >70% efficiency. This has made it possible to explore parameters and identify several different new regimes of propagation relevant to the pacemaking function of SR calcium release in sin0-atrial node cells. Extensive simulations have been performed as a function of critical parameters regulating heart rate. The model successfully expalins the various regimes of localized and global calcium release and the transition among these regimes as a function of release current. These results are consistent with a new model of how heart rate is regulated by the autonomic nervous system. A publication is presently being reviewed by journal.