Salk Institute for Biological Studies NINDS Center Core Grant

索尔克生物研究所请求支持一项新的神经科学研究中心核心拨款。自20世纪60年代该研究所成立以来，神经科学已成为索尔克教职员工的主要研究重点。超过一半的教职员工领导着32个研究所的实验室，目前主要从事神经科学研究。教师的主要研究兴趣被归类为几个广泛的规划领域：临床和翻译神经科学、分子和细胞神经科学、神经发育和系统神经科学。NINDS目前资助了17个研究项目，支持12名教职员工担任首席研究员。这些奖项包括九个独立的R01/R37研究项目、一个积极的RC2(重大机遇)奖、一个K99和一个P01计划项目。9名索尔克调查人员要么是现任的，要么是过去的雅各布·贾维茨获奖者。该中心核心助学金申请的具体目的是为当前和未来NINDS资助的研究项目所需的关键资源提供支持。拟议的三个新的核心资源：1)基因组操作核心，提供服务，为体内和体外基因功能分析和神经疾病模型生产基因靶向ES细胞系；2)成像核心，专注于对透射电子显微镜超微结构成像的专门支持，并促进跨多个先进成像平台的集成结构分析；以及3)行为核心，提供在小动物行为分析方面的专业知识，并提供不同测试模式的一致性。这些核心的管理将首先集中为8名索尔克研究所的研究人员提供支持，这些研究项目目前由NINDS资助的R01/R37研究项目。任何过剩的核心能力都将提供给索尔克研究所的其他研究人员，他们的研究项目与NINDS的使命一致。这一基础设施计划将提供核心服务，促进将不断发展的先进技术应用于索尔克研究所由NINDS资助的研究项目，并利用现有资金作为资源倍增器，更好地推动这些项目，解决与NINDS任务相关的重要问题。

The Salk Institute for Biological Studies requests support for a new Center Core Grant for Neuroscience Research. Since the founding of the Institute in the 1960s, neuroscience has grown to be the major research emphasis of Salk faculty. Over half of the faculty, heading 32 Institute laboratories, are currently engaged primarily in neuroscience research. The major research interests of the faculty are grouped into several broad programmatic areas: Clinical and Translational Neuroscience, Molecular and Cellular Neuroscience, Neural Development, and Systems Neuroscience. Seventeen research projects, supporting twelve faculty as principal investigators, are currently funded by NINDS. These awards include nine independent R01/R37 research projects, an active RC2 (Grand Opportunities) award, a K99, and a P01 program project. Nine Salk investigators are either current or past Jacob Javits awardees. The specific aim of this Center Core Grant application is to provide support for key resources that are needed for current and future NINDS-funded research projects. Three new core resources are proposed: 1) a Genome Manipulation Core, providing services to produce gene-targeted ES cell lines for in vivo and in vitro models for functional analysis of genes and neurologic disease, 2) an Imaging Core, focusing on dedicated support for TEM ultrastructural imaging and fostering integrated structural analysis across multiple advanced imaging platforms, and 3) a Behavior Core, providing both dedicated expertise in small animal behavioral analysis and consistency across different testing modalities. The management of these cores will focus first on providing support for the eight Salk Institute investigators with current NINDS-funded R01/R37 research programs. Any excess core capacity will be made available to other investigators at The Salk Institute who have research projects that are consistent with the mission of NINDS. This infrastructure program will provide core services that will facilitate application of continually evolving advanced technologies to the NINDS-funded research projects at the Salk Institute, and leverage existing funding as a resource multiplier to better advance these projects in addressing important problems relevant to the NINDS mission.