Salk Institute for Biological Studies NINDS Center Core Grant

索尔克生物研究所请求为神经科学研究新中心核心拨款提供支持。自 20 世纪 60 年代研究所成立以来，神经科学已成为索尔克学院教师的主要研究重点。超过一半的教员领导 32 个研究所实验室，目前主要从事神经科学研究。该学院的主要研究兴趣分为几个广泛的领域：临床和转化神经科学、分子和细胞神经科学、神经发育和系统神经科学。目前，NINDS 资助了 17 个研究项目，支持 12 名教师作为主要研究人员。这些奖项包括九个独立的 R01/R37 研究项目、一个活跃的 RC2（大机会）奖、一个 K99 和一个 P01 计划项目。索尔克的九名调查员都是现任或过去的雅各布·贾维茨获奖者。该中心核心拨款申请的具体目的是为当前和未来 NINDS 资助的研究项目所需的关键资源提供支持。提出了三个新的核心资源：1）基因组操作核心，提供服务以生产用于体内和体外模型的基因靶向 ES 细胞系，用于基因和神经系统疾病的功能分析；2）成像核心，专注于对 TEM 超微结构成像的专门支持，并促进跨多个先进成像平台的集成结构分析；3）行为核心，提供小动物行为分析方面的专业知识和不同测试模式的一致性。这些核心的管理将首先侧重于为索尔克研究所的八名研究人员提供当前由 NINDS 资助的 R01/R37 研究项目的支持。任何多余的核心能力将提供给索尔克研究所的其他研究人员，他们的研究项目与 NINDS 的使命一致。该基础设施计划将提供核心服务，促进不断发展的先进技术应用于索尔克研究所 NINDS 资助的研究项目，并利用现有资金作为资源倍增器，更好地推进这些项目，解决与 NINDS 任务相关的重要问题。

The Salk Institute for Biological Studies requests support for a new Center Core Grant for Neuroscience Research. Since the founding of the Institute in the 1960s, neuroscience has grown to be the major research emphasis of Salk faculty. Over half of the faculty, heading 32 Institute laboratories, are currently engaged primarily in neuroscience research. The major research interests of the faculty are grouped into several broad programmatic areas: Clinical and Translational Neuroscience, Molecular and Cellular Neuroscience, Neural Development, and Systems Neuroscience. Seventeen research projects, supporting twelve faculty as principal investigators, are currently funded by NINDS. These awards include nine independent R01/R37 research projects, an active RC2 (Grand Opportunities) award, a K99, and a P01 program project. Nine Salk investigators are either current or past Jacob Javits awardees. The specific aim of this Center Core Grant application is to provide support for key resources that are needed for current and future NINDS-funded research projects. Three new core resources are proposed: 1) a Genome Manipulation Core, providing services to produce gene-targeted ES cell lines for in vivo and in vitro models for functional analysis of genes and neurologic disease, 2) an Imaging Core, focusing on dedicated support for TEM ultrastructural imaging and fostering integrated structural analysis across multiple advanced imaging platforms, and 3) a Behavior Core, providing both dedicated expertise in small animal behavioral analysis and consistency across different testing modalities. The management of these cores will focus first on providing support for the eight Salk Institute investigators with current NINDS-funded R01/R37 research programs. Any excess core capacity will be made available to other investigators at The Salk Institute who have research projects that are consistent with the mission of NINDS. This infrastructure program will provide core services that will facilitate application of continually evolving advanced technologies to the NINDS-funded research projects at the Salk Institute, and leverage existing funding as a resource multiplier to better advance these projects in addressing important problems relevant to the NINDS mission.