Salk Institute for Biological Studies NINDS Center Core Grant

索尔克生物研究所 NINDS 中心核心资助

• 批准号: 8216158
• 负责人: DENNIS D O'LEARY
• 金额: $ 85.94万
• 依托单位: SALK INSTITUTE FOR BIOLOGICAL STUDIES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-26 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8216158
• 关键词: Salk; Institute; Biological; Studies; NINDS

The Salk Institute for Biological Studies requests support for a new Center Core Grant for Neuroscience Research. Since the founding of the Institute in the 1960s, neuroscience has grown to be the major research emphasis of Salk faculty. Over half of the faculty, heading 32 Institute laboratories, are currently engaged primarily in neuroscience research. The major research interests of the faculty are grouped into several broad programmatic areas: Clinical and Translational Neuroscience, Molecular and Cellular Neuroscience, Neural Development, and Systems Neuroscience. Seventeen research projects, supporting twelve faculty as principal investigators, are currently funded by NINDS. These awards include nine independent R01/R37 research projects, an active RC2 (Grand Opportunities) award, a K99, and a P01 program project. Nine Salk investigators are either current or past Jacob Javits awardees. The specific aim of this Center Core Grant application is to provide support for key resources that are needed for current and future NINDS-funded research projects. Three new core resources are proposed: 1) a Genome Manipulation Core, providing services to produce gene-targeted ES cell lines for in vivo and in vitro models for functional analysis of genes and neurologic disease, 2) an Imaging Core, focusing on dedicated support for TEM ultrastructural imaging and fostering integrated structural analysis across multiple advanced imaging platforms, and 3) a Behavior Core, providing both dedicated expertise in small animal behavioral analysis and consistency across different testing modalities. The management of these cores will focus first on providing support for the eight Salk Institute investigators with current NINDS-funded R01/R37 research programs. Any excess core capacity will be made available to other investigators at The Salk Institute who have research projects that are consistent with the mission of NINDS. This infrastructure program will provide core services that will facilitate application of continually evolving advanced technologies to the NINDS-funded research projects at the Salk Institute, and leverage existing funding as a resource multiplier to better advance these projects in addressing important problems relevant to the NINDS mission.

索尔克生物研究所请求支持一个新的神经科学研究中心核心拨款。自20世纪60年代该研究所成立以来，神经科学已成为索尔克教师的主要研究重点。超过一半的教师，领导32个研究所实验室，目前主要从事神经科学研究。该学院的主要研究兴趣分为几个广泛的计划领域：临床和转化神经科学，分子和细胞神经科学，神经发育和系统神经科学。17个研究项目，支持12名教师作为主要研究人员，目前由NINDS资助。这些奖项包括九个独立的R 01/R37研究项目，一个活跃的RC 2（大机会）奖，一个K99和一个P01计划项目。九名索尔克调查员是现任或前任雅各布·贾维茨获奖者。该中心核心补助金申请的具体目的是为当前和未来NINDS资助的研究项目所需的关键资源提供支持。拟议增加三项核心资源：1）基因组操作核心，提供服务以产生用于基因和神经疾病的功能分析的体内和体外模型的基因靶向ES细胞系，2）成像核心，专注于对TEM超微结构成像的专门支持并促进跨多个先进成像平台的集成结构分析，以及3）行为核心，提供小动物行为分析方面的专业知识和不同测试模式的一致性。这些核心的管理将首先侧重于为Salk研究所的八名研究人员提供支持，这些研究人员目前正在进行NINDS资助的R 01/R37研究项目。任何多余的核心能力将提供给索尔克研究所的其他研究人员，他们的研究项目与NINDS的使命一致。该基础设施计划将提供核心服务，促进将不断发展的先进技术应用于索尔克研究所NINDS资助的研究项目，并利用现有资金作为资源乘数，更好地推进这些项目，解决与NINDS使命相关的重要问题。