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Cytolytic T Cell Activity In Response To Primary RSV Infection In Mice

Cytolytic T Cell Activity In Response To Primary RSV Infection In Mice
小鼠原发性 RSV 感染的溶细胞 T 细胞活性
批准号：
8148428
负责人：
Barney Graham
金额：
$94.01万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8148428
关键词：
Cytotoxic T-LymphocytesInfectionMusresponse

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中文摘要
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英文摘要
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in infants and small children. RSV infection is characterized by significant immunopathology, which is mediated by CD8+ cytotoxic T lymphocytes (CTL). Past studies have suggested that the multiple mechanisms employed by CTLs to eliminate cells may have differential effects on viral clearance and RSV-associated illness. This study seeks to define the contributions of the different CTL effector mechanisms and CD25+ T regulatory cells to the clearance of primary RSV infection, as well as their relative impact on the virus-associated immunopathology.
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Cellular Immune Responses to RSV infection in Mice
Rapid Development of Vaccines for Emerging Viruses
Factors Contributing To Immune-Enhanced Disease In The Pathogenesis of RSV
Vectors and Methods to Increase Immunogenicity during DNA Vaccination
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