Measurement of Renal Viscoelastic Properties with Ultrasound

超声测量肾粘弹特性

• 批准号: 8838774
• 负责人: Matthew William Urban
• 金额: $ 41.36万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-07 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8838774
• 关键词: Adult; American; Biopsy; Chronic Kidney Failure; Clinical; Clinical Management; Computer software; Coronary artery; Coupled; Creatinine; Data; Diagnosis; Disease; Elasticity; End stage renal failure; Focused Ultrasound; Frequencies; Geometry; Glomerular Filtration Rate; Goals; Gold; Graft Rejection; Graft Survival; Health; Hemodialysis; Histocompatibility Testing; Human; Image; Kidney; Kidney Diseases; Kidney Failure; Kidney Transplantation; Knowledge; Life; Liver; Measurement; Measures; Medical; Medical Imaging; Methods; Modality; Modeling; Modification; Monitor; Nature; Pathology; Patient Monitoring; Patients; Physicians; Procedures; Process; Property; Prostate; Radiation; Renal function; Research; Research Proposals; Serum; Skeletal Muscle; Speed; Structure; Survival Rate; System; Techniques; Therapeutic Intervention; Tissues; Transducers; Translations; Transplantation; Treatment Protocols; Ultrasonography; Validation; Viscosity; Visit; aged; base; diagnosis standard; follow-up; healthy volunteer; human subject; imaging modality; improved; in vivo; insight; non-invasive imaging; outcome forecast; programs; screening; simulation; soft tissue; tool; viscoelasticity

DESCRIPTION (provided by applicant): Background: Chronic kidney disease (CKD) encompasses a long-term decrease in function of the kidneys which afflicts 11.5% in American adults aged 20 and over, which is more than 20 million people. CKD can progress to kidney failure or end-stage renal disease (ESRD). At the end of 2008, 547,982 patients were receiving ESRD therapy, which includes hemodialysis or kidney transplant. Patient and renal graft survival rates have increased over the past five decades, but long-term survival of grafts is still an issue. Renal biopsy is the gold standard for diagnosis of kidney health, but is an invasive procedure, can not be used frequently, and can cause complications. Noninvasive indicators of kidney disease including levels of serum creatinine, glomerular filtration rate, and classical medical imaging can provide certain insights into kidney disease state. Elasticity imaging methods are emerging as a way to discriminate healthy versus diseased tissue based on the elasticity or viscosity of the tissue. When the structure of tissue changes due to disease processes, the function and viscoelastic properties also change. We propose the use of a quantitative, noninvasive method called shearwave dispersion ultrasound vibrometry (SDUV) to measure these quantities for assessment of renal health. Method: SDUV uses focused ultrasound to "push" the tissue and create shear waves. Ultrasound-based methods are used to detect the propagation of the shear waves through the tissue. The propagation speed of the shear waves varies with frequency, a phenomenon known as dispersion. This shear wave speed dispersion can be used to evaluate the shear elasticity and viscosity of the tissue. Studies in many different types of tissue including liver, kidney, skeletal muscle, prostate, heart and arteries have shown that SDUV can be a useful method for quantitatively evaluating the viscoelastic properties of tissue. SDUV measurements are noninvasive, fast, and localized to a small region of tissue. This noninvasive measurement technique can be suitable as a first-line screening tool to reduce the numbers of biopsies. Additionally, it can be used as a quantitative indicator for frequent assessment and monitoring of patients undergoing treatment regimens to track progress. SDUV techniques developed in this project could be implemented on modern ultrasound scanners with software modifications for widespread clinical translation. Aims: 1. Develop analytic methods and optimize implementation of SDUV for viscoelastic characterization of the native and transplanted human kidney. 2. Study the relationships between SDUV measurements of the viscoelastic properties of native kidneys of healthy kidney donors and patients with chronic kidney disease. 3. Study the relationship between SDUV measurements of viscoelastic material properties with clinical measures for assessment of kidney transplant rejection.

描述（由申请人提供）：背景：慢性肾脏疾病（CKD）包括肾脏功能的长期降低，在20岁及20岁以上的美国成年人中折磨了11.5％，超过2000万人。 CKD可以发展为肾功能衰竭或末期肾脏疾病（ESRD）。在2008年底，有547,982例患者接受了ESRD疗法，其中包括血液透析或肾脏移植。在过去的五十年中，患者和肾移植物存活率有所提高，但移植物的长期存活仍然是 一个问题。肾脏活检是诊断肾脏健康的黄金标准，但是一种侵入性手术，不能经常使用，并且可能引起并发症。肾脏疾病的无创指标，包括血清肌酐水平，肾小球滤过率和经典医学成像可以提供对肾脏疾病状态的某些见解。弹性成像方法正在作为一种基于组织的弹性或粘度来区分健康组织与患病组织的一种方式。当组织的结构因疾病过程而发生变化时，功能和粘弹性也会改变。我们建议使用一种称为剪力波分散超声振动（SDUV）的定量，无创方法来测量这些数量以评估肾脏健康。方法：SDUV使用聚焦超声来“推”组织并产生剪切波。基于超声的方法用于检测剪切波通过组织的传播。剪切波的传播速度随频率而变化，这种现象称为分散。这种剪切波速度分散剂可用于评估组织的剪切弹性和粘度。在许多不同类型的组织中进行的研究，包括肝脏，肾脏，骨骼肌，前列腺，心脏和动脉，表明SDUV可能是定量评估组织粘弹性特性的有用方法。 SDUV测量是无创，快速的，并且位于一小部分组织区域。这种无创测量技术可以作为减少活检数量的一线筛查工具。此外，它可以用作频繁评估和监测接受治疗方案以跟踪进度的患者的定量指标。该项目中开发的SDUV技术可以在现代超声扫描仪上实施，并具有软件修改以进行广泛的临床翻译。目的：1。开发分析方法并优化SDUV的实施，以实现天然和移植的人肾脏的粘弹性表征。 2。研究健康肾脏供体的天然肾脏的粘弹性特性与患有慢性肾脏疾病的患者的粘弹性特性之间的关系。 3。研究粘弹性材料特性的SDUV测量与评估肾脏移植排斥反应的临床措施之间的关系。