Biospecimen Research Network (OBBR)

生物样本研究网络 (OBBR)

• 批准号: 8182049
• 负责人: LARRY ARTHUR
• 金额: $ 100万
• 依托单位: LEIDOS BIOMEDICAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2018-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8182049
• 关键词: Address; Advanced Technology Center; Blood; Collection; Communities; Contracts; Data; Databases; Development; Diagnostic; Emerging Technologies; Extramural Activities; Funding; Genomics; Goals; Human; Individual; Laboratories; Liquid substance; Literature; Molecular; National Cancer Institute; Outcome; Process; Proteomics; Quality Indicator; Research; Research Project Grants; Resources; Series; Services; Specimen; Standardization; Tissue Banks; United States National Institutes of Health; Vision; anticancer research; base; biobank; clinical Diagnosis; clinical practice; design; evidence base; improved; meetings; outreach; programs; prospective; symposium; web site

This contract funding supports the Biospecimen Research Network, managed by the National Cancer Institute (NCI) Office of Biorepositories and Biospecimen Research."In early 2006, the NCI Office of Biorepositories and Biospecimen Research (OBBR) initiated the Biospecimen Research Network (BRN) to systematically address the impact of specific variables in individual specimen types on molecular data from given analysis platforms. The goal of the BRN is to address these issues by sponsoring, conducting, and collaborating on studies to assess the effects of human specimen pre-analytical variables on the outcome of genomic and proteomic studies conducted for clinical diagnosis and cancer research purposes. By communicating the results of such research to the scientific community, the BRN aims to significantly improve the quality of NCI-funded biospecimen-based research. The results of BRN research will support NCI discovery efforts and contribute to the development of evidence-based best practices for the collection, processing, storage, and analysis of biospecimens, building on the ""NCI Best Practices for Biospecimen Resources."" Based on this vision, the BRN has been designed to address the following challenges: * Bridging the gap between existing clinical practice for biospecimens and emerging technologies for personalized diagnostics and therapies * Defining the most significant variables for prospective collection of tissues, blood, and bodily fluids * Developing evidence-based biospecimen quality indicators for specific analytical platforms The activities of the BRN program to date include the following: * A public outreach effort to define issues around human specimen research and identify the most pressing needs for human analyte standardization. Activities include an annual meeting, the BRN Symposium. * Provision of consultative services on biospecimen issues for programs within the NCI and NIH * A series of research projects underway at the BRN laboratory located at the Advanced Technology Center in Gaithersburg with intramural and extramural collaborators * Development of a searchable Web site of the existing biospecimen literature, the Biospecimen Research Database "

该合同资金支持由国家癌症研究所（NCI）生物储存库和生物标本研究办公室管理的生物标本研究网络。2006年初，NCI生物储存库和生物样本研究办公室（OBBR）启动了生物样本研究网络（BRN），以系统地解决单个样本类型中特定变量对给定分析平台分子数据的影响。BRN的目标是通过赞助、开展和合作研究来解决这些问题，以评估人类标本分析前变量对用于临床诊断和癌症研究目的的基因组和蛋白质组学研究结果的影响。通过将这些研究的结果传达给科学界，BRN旨在显著提高NCI资助的生物技术研究的质量。BRN研究的结果将支持NCI的发现工作，并有助于在“NCI生物标本资源最佳实践”的基础上，为生物标本的收集、处理、储存和分析制定基于证据的最佳实践。"" 基于这一愿景，BRN旨在应对以下挑战： * 弥合生物标本现有临床实践与个性化诊断和治疗新兴技术之间的差距 * 定义组织、血液和体液前瞻性采集的最重要变量 * 为特定分析平台制定循证生物样本质量指标 迄今为止，BRN方案的活动包括： * 一项公共宣传工作，以确定人类标本研究的问题，并确定人类分析物标准化的最迫切需求。活动包括年会、BRN研讨会。 * 为NCI和NIH内的项目提供有关生物标本问题的咨询服务 * 位于盖瑟斯堡先进技术中心的BRN实验室正在与校内和校外合作者进行一系列研究项目 * 开发一个现有生物标本文献的可检索网站，即生物标本研究数据库 "