Bio-Imaging and Confocal Microscopy

项目摘要-生物成像和共聚焦显微镜 OHSU的生物成像和共焦显微镜核心将提供仪器和支持 荧光和共聚焦显微镜以及光谱域光学相干层析成像(SDOCT) 加强和促进OHSU的视力研究。主要的仪器和专业知识已经到位。 在凯西眼科研究所(CEI)。过去P30对CEI共焦和荧光成像系统的支持 取得了极大的成功，支持的仪器的数据出现在50份出版物中 之前的5年资助期。下一个资助期的变化包括增加小动物 至核心的SDOCT仪器。Bioptigen SDOCT设备使重复的、无创的 视网膜和眼睛的活体成像，将大大加强CEI正在进行和计划中的研究项目 旨在提高视力疾病的治疗水平。凯瑟琳·摩根博士，共焦和 荧光显微镜，将继续担任生物成像核心主任，马克·彭内西博士， 啮齿动物SDOCT专家将与OCT技术的共同发明者David Huang博士一起提供指导 以及对SDOCT新用户的培训。校长将获得有关所有乐器的培训机会。 研究人员、博士后研究员和研究生。

PROJECT SUMMARY - BIO-IMAGING AND CONFOCAL MICROSCOPY The Bio-Imaging & Confocal Microscopy Core at OHSU will provide instrumentation and support for fluorescence and confocal microscopy as well as spectral domain optical coherence tomography (SDOCT) to enhance and facilitate vision research at OHSU. The major instrumentation and expertise are already in place at the Casey Eye Institute (CEI). Past P30 support of confocal and fluorescence imaging systems at the CEI has been extremely successful, with data from the supported instruments featuring in 50 publications during the previous 5-year funding period. Changes in the next funding period include the addition of small animal SDOCT instrumentation to the Core. The Bioptigen SDOCT device makes possible repeated, noninvasive, in vivo imaging of the retina and eye and will substantially enhance ongoing and planned research projects at CEI aimed at improving the treatment of visual diseases. Dr. Catherine Morgans, an expert in confocal and fluorescence microscopy, will continue to serve as Director of the Bio-Imaging Core, and Dr. Mark Pennessi, expert at rodent SDOCT, along with Dr. David Huang, co-inventor of OCT technology, will provide guidance and training to new SDOCT users. Training opportunities on all instruments will be available to principal investigators, postdoctoral fellows, and graduate students.