MMT CARE For HIV Prevention: A Randomized Controlled Trial

MMT CARE 预防艾滋病毒：一项随机对照试验

• 批准号: 8804930
• 负责人: Li Li
• 金额: $ 51.95万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-01 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8804930
• 关键词: AIDS prevention; AIDS/HIV problem; Address; Adherence; Attitude; Behavior; Behavior Therapy; Behavioral; Centers for Disease Control and Prevention (U.S.); China; Chinese People; Client; Clinic; Communication; Communities; Control Groups; Counseling; Country; Data; Dimensions; Dropout; Drops; Drug abuse; Drug usage; Education; Environment; Epidemic; Evidence based intervention; Face; Foundations; Goals; HIV; HIV risk; Harm Reduction; Health Services Accessibility; Heroin; Individual; Intervention; Life; Link; Maintenance Therapy; Measures; Mental Health; Modeling; Motivation; Movement; Outcome; Population; Prevention; Prevention approach; Preventive Intervention; Provider; Province; Randomized; Randomized Controlled Trials; Recruitment Activity; Research; Resistance; Risk Behaviors; Risk Reduction; Services; Training; Treatment Efficacy; Treatment Protocols; Treatment outcome; behavior change; design; disorder prevention; group intervention; high risk; improved; innovation; methadone maintenance; programs; psychosocial; response; scale up; skills; social stigma; transmission process; treatment adherence; treatment program

DESCRIPTION (provided by applicant): We propose a 5-year randomized controlled trial that targets methadone maintenance treatment (MMT) programs in China. Applying the principles of combination prevention, the proposed intervention (MMT CARE) integrates psychosocial and behavioral components into a pharmacological framework for methadone maintenance. A total of 68 MMT clinics will be randomly selected from four provinces. From each clinic, 6 service providers and 36 clients will be recruited, totaling 408 providers and 2,448 clients in the study. The 68 clinics will be randomized to: 1) a MMT CARE intervention group, or 2) a control group (34 clinics each). Service providers who complete the training will conduct three individual motivational enhancement sessions with clients. Efficacy of the intervention will be evaluated at baseline and at 3, 6, 12, 18, and 24-month follow- ups. The outcomes for service providers will be measured by: 1) improved adherence to MMT protocols; 2) decreased prejudicial attitudes; 3) increased interaction with clients; and 4) increased communications with clients about risk reduction. The outcomes for clients will be measured by: 1) improved treatment adherence/retention; 2) decreased concurrent drug use; 3) increased motivation for behavior change; 4) improved mental health; 5) increased positive support; and 6) reduced HIV risk behaviors.

描述（由申请人提供）：我们提出了一项针对中国美沙酮维持治疗（MMT）项目的5年随机对照试验。应用组合预防的原则，拟议的干预措施（MMT CARE）将社会心理和行为成分整合到美沙酮维持的药理学框架中。将从四个省随机选择68家MMT诊所。每个诊所将招募6名服务提供者和36名客户，研究中总共有408名服务提供者和2，448名客户。68家诊所将随机分配至：1）MMT CARE干预组，或2）对照组（各34家诊所）。完成培训的服务提供者将与客户进行三次个人激励增强会议。将在基线和3、6、12、18和24个月随访时评价干预的有效性。服务提供者的结果将通过以下方面来衡量：1）改善对MMT协议的遵守; 2）减少偏见态度; 3）增加与客户的互动; 4）增加与客户关于降低风险的沟通。客户的结果将通过以下方式衡量：1）改善治疗依从性/保留率; 2）减少同时使用药物; 3）增加改变行为的动机; 4）改善心理健康; 5）增加积极支持; 6）减少艾滋病毒风险行为。