In Vivo Micro-Computed Tomography Imaging System

 描述(由申请人提供)：这项提案的目标是购买活体，三维微型计算机断层成像系统。该系统能够数字化活体解剖结构的三维形态和微结构，分辨率高达9微米各向同性体素大小。该系统将完全取代过去八年来一直是密歇根大学核心设施运营一部分的系统，但将不再得到供应商的支持，不再支持该机构调查人员的高分辨率需求。我们的核心设施拥有体内和体外MicroCT成像系统，这些成像系统涵盖了体外亚微米体素尺寸到45微米体内成像。购买这一新系统的主要理由是基于一大批资金充足的研究人员的需求，这些研究人员现在需要更精细的体内分辨率、更低的辐射剂量以及进一步的扫描控制，包括心脏和呼吸门控，以促进正在进行的和新的研究。通过体内微型计算机断层扫描系统可以获得的数据使研究人员能够研究与骨骼疾病、生长发育、衰老和脆弱、再生医学策略、癌症和转移性肿瘤侵袭、糖尿病、代谢性疾病和骨关节炎相关的机制。此外，该系统还提供了对不适合我们当前体外系统的物体进行体外高分辨率成像的能力，例如大型解剖标本和包括木乃伊动物在内的考古文物。

 DESCRIPTION (provided by applicant): The objective of this proposal is to purchase an in vivo, three-dimensional micro-computed tomography imaging system. This system has the capability of digitizing the three-dimensional morphology and microarchitecture of anatomic structures in vivo, at resolutions up to 9 micron isotropic voxel size. This system will essentiall replace a system that has been part of a Core facility operation at the University of Michigan for the past eight years, but will no longer be supported by the vendor, and no longer supports the high resolution needs of investigators at the institution. Our Core facility houses both in vivo an ex vivo microCT imaging systems which span in vitro sub-micron voxel size to 45 micron in vivo imaging. The principal rational for the purchase of this new system is based on the needs of a large group of well-funded investigators which now requires more refined in vivo resolution, lower radiation doses, and further scan control including cardiac and respiratory gating to facilitate ongoing and new investigations. The data that can be acquired with the in vivo micro-computed tomography system enables investigators to study mechanisms associated with skeletal diseases, growth and development, aging and fragility, regenerative medicine strategies, cancer and metastatic tumor invasion, diabetes, metabolic disease, and osteoarthritis. Additionally, the system offers the ability to perform ex vivo high resolution imaging on objects that cannot fit into our current ex vivo systems, such as large anatomic specimens and archaeological artifacts including mummified animals.