SARRP 200 Small animal radiation research platform

 说明(申请人提供)：本次共享仪器申请是为了支持购买小动物辐射研究平台(SARRP)。Xstrahl提供的技术是独一无二的，它将锥形束CT与计算机控制的旋转治疗X射线管相结合。与治疗计划软件相结合，这种硬件允许进行三维放射治疗计划，并将其提供给模仿用于治疗人类肿瘤的体积方法的模型生物。这一新一代系统利用小动物CT的最新进展来产生真正的图像引导放射治疗，或称IGRT。该设备结合了一个360度旋转龙门和一个可在3个维度上旋转和平移的工作台，以允许从任何角度输送多个X射线束并汇聚到肿瘤上。该系统将取代俄亥俄州立大学目前的技术，该技术基于已有50年历史的机柜X光机设计。俄亥俄州立大学的机柜X射线设备是RS2000，这是一个固定在密封机柜顶部的点源X射线发生器。为了治疗动物，人们必须使用手动放置铅屏蔽物的方式，以屏蔽小鼠的一部分，并只允许X射线传输到模型肿瘤。SARRP将通过目前资助的9个NIH项目加强6个主要用户的研究，这些项目横跨OSUCCC的放射肿瘤学、神经外科、分子病毒学、免疫学和医学遗传学部门，以及全国儿童研究所的实验治疗计划。此外，SARRP设备将被纳入放射肿瘤学系医学物理学研究生课程的培训中。最后，SARRP将被合并到俄亥俄州立大学神经科学中心(P30)核心提供的原位脑瘤植入服务中。这一核心旨在支持脑瘤治疗新技术的开发。目前和未来使用这一核心的研究人员现在将能够将放射治疗与他们的新模式结合起来，希望产生创新的、协同的疗法来治疗脑瘤。

 DESCRIPTION (provided by applicant): This shared instrument application is to support the purchase of a small animal radiation research platform (SARRP). The technology available from Xstrahl is unique and combines a cone beam CT with a computer controlled rotating treatment x-ray tube. In combination with the treatment planning software, this hardware allows for 3-dimensional radiotherapy treatment planning and delivery to model organisms that mimics the volumetric approach used to treat human tumors. This next-generation system leverages the recent advances in small animal CT to generate true image guided radiotherapy, or IGRT. The device incorporates a 360o rotating gantry with a stage that rotates and translates in 3 dimensions to allow for multiple x-ray beamlets to be delivered from any angle and converge upon the tumor. This system will replace the current technology at Ohio State University that is based on 50 year old design for cabinet X-ray machines. The cabinet x-ray device at Ohio State University is an RS2000, a point source X-ray generator fixed to the top of a sealed cabinet. In order to treat animals, one must use manual placement of lead shielding in such a way as to shield a portion of the mouse and allow x-ray delivery only to the model tumor. The SARRP will enhance the research of 6 major users with 9 currently funded NIH projects that span the departments of Radiation Oncology, Neurosurgery, and Molecular Virology, Immunology and Medical Genetics at OSUCCC and the Experimental Therapeutics program at Nationwide Children's Research Institute. In addition, the SARRP device will be incorporated into the training for the graduate program in medical physics run in the department of Radiation Oncology. Finally, the SARRP will be combined into the services that are offered at the OSU Neuroscience Center (P30) core for orthotopic brain tumor implantation. This core is designed to support the development of new technologies for the treatment of brain tumors. Current and future investigators using this core will now be able to incorporate radiotherapy with their novel modalities in the hope of generating innovative, synergistic therapeutics to treat brain tumors.