Brain dynamics of lexical selection in speech production

言语产生中词汇选择的大脑动力学

• 批准号: 8878214
• 负责人: Stephanie Ries-Cornou
• 金额: $ 5.8万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2016-08-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8878214
• 关键词: Address; Adult; Anomia; Attention; Behavior; Brain; Brain Injuries; Brain imaging; Brain region; Coupling; Electrocorticogram; Electrodes; Electroencephalography; Electrophysiology (science); Evoked Potentials; Financial compensation; Frequencies; Functional Magnetic Resonance Imaging; Goals; Health; Imaging Techniques; Individual; Inferior; Injury; Investigation; Knowledge; Laboratories; Language; Left; Linguistics; Measures; Medial; Memory; Modeling; Neurodegenerative Disorders; Neurologic; Neuronal Plasticity; Neurons; Patients; Pattern; Performance; Phase; Physiological; Physiology; Play; Prefrontal Cortex; Process; Production; Psyche structure; Recovery; Relative (related person); Research; Response to stimulus physiology; Role; Signal Transduction; Site; Speech; Stimulus; Stroke; Surface; Temporal Lobe; Testing; Time; Training Programs; aged; aphasic; base; behavior measurement; behavioral study; cognitive control; cognitive function; cost; experience; indexing; injured; language processing; lexical; lexical processing; memory retrieval; normal aging; novel; post stroke; relating to nervous system; response; skills; tool

DESCRIPTION (provided by applicant): In normal speech, adults fluidly utter 2 to 3 words per second selected from no less than 50,000 to 100,000 regularly-used words in the mental lexicon. Lexical selection is the process by which we access and fit an appropriate word to ongoing speech and is a core process for language production. Pathological disruption of lexical selection (i.e., anomia) is observed to some extent in all aphasic patients and can also be present in neurodegenerative diseases as well as normal aging. Despite the central importance of lexical selection to language and the immense personal and societal cost caused by its disruption, its neural basis and that involved in its recovery are poorly understood. Different regions of the prefrontal cortex (PFC) and of the left temporal cortex (LTC) have been associated with lexical selection but their precise role and the way they interact to enable lexica selection and compensation are still unknown. This lack of knowledge has both methodological and theoretical causes: (a) The brain imaging techniques generally used to study healthy speakers do not provide temporal information on the brain regions that are involved in lexical selection. Knowing when these different regions come online during lexical processing would confirm their different roles and would also suggest how they interact with each other to achieve lexical processing. (b) Language has typically been considered in isolation from other cognitive functions. A burgeoning body of evidence suggests that lexical selection is dependent on domain-general cognitive control mechanisms. If this is true, it would suggest that different brain regions play different linguistic and non-linguistic roles, a finding that would have significant ramifications for treatment and recovery of brain-injured patients. The goal of the proposed research is to test the hypotheses that: (1) Lexical selection is supported by top-down modulations from the left PFC onto the left LTC, similar to how non-linguistic action selection is controlled, and (2) The right PFC serves as a compensatory top-down mechanism for lexical selection when the left PFC is injured, similar to what has been shown outside of the language domain. To test these hypotheses, a combination of novel theoretical and methodological approaches will be used. First, the unique opportunity to record electrocorticography (ECoG) in neurosurgical patients will be used to determine which, when and how subregions of the PFC and the LTC are involved in lexical selection. Second, linguistic vs. domain-general contributions to lexical processing will be tested by directly comparing patients' performance on two tasks using the same stimuli, but differing only in the type of stimulus-response associations to be performed (linguistic vs. domain-general). Finally, these same tasks will be used with neurological patients recovering from stroke in either the left or right PFC in order to determine the effects of these injuries on lexical selection. Behavioral measurements as well as surface EEG signals will determine the relative roles of these regions in lexical selection, and whether the right PFC participates in compensating for the loss of top-down control when the left PFC is injured.

描述（由申请人提供）：在正常言语中，成年人每秒流畅地说出2至3个单词，这些单词选自心理词典中不少于50，000至100，000个常用单词。词汇选择是我们获取合适的词并使之适合正在进行的言语的过程，是语言产生的核心过程。词汇选择的病理性破坏（即，失名症）在某种程度上在所有失语症患者中观察到，并且也可以存在于神经变性疾病以及正常衰老中。尽管词汇选择对语言至关重要，而且它的破坏造成了巨大的个人和社会成本，但人们对它的神经基础及其恢复所涉及的神经基础知之甚少。前额叶皮层（PFC）和左颞叶皮层（LTC）的不同区域与词汇选择有关，但它们的确切作用以及它们相互作用以实现词汇选择和补偿的方式仍然未知。这种知识的缺乏既有方法上的原因，也有理论上的原因：（a）通常用于研究健康说话者的大脑成像技术不能提供有关词汇选择的大脑区域的时间信息。了解这些不同的区域在词汇加工过程中何时上线，将确认它们的不同角色，也将表明它们如何相互作用以实现词汇加工。(b)语言通常被认为与其他认知功能无关。越来越多的证据表明，词汇选择依赖于一般领域的认知控制机制。如果这是真的，那就意味着 不同的区域扮演着不同的语言和非语言角色，这一发现将对脑损伤患者的治疗和康复产生重大影响。本研究的目的是验证以下假设：（1）词汇选择是由左前额叶皮层到左长时皮层的自上而下的调节支持的，类似于非语言动作选择的控制方式;（2）当左前额叶皮层受损时，右前额叶皮层作为词汇选择的自上而下的补偿机制，类似于语言域之外的情况。为了检验这些假设，将使用新的理论和方法相结合的方法。首先，独特的机会，记录皮层电图（ECoG）在神经外科患者将被用来确定哪些，何时以及如何次区域的PFC和LTC参与词汇选择。第二，通过直接比较患者在使用相同刺激的两项任务上的表现来测试语言与一般领域对词汇处理的贡献，但不同之处仅在于要执行的刺激-反应关联的类型（语言与一般领域）。最后，这些相同的任务将被用于从中风中恢复的神经系统患者的左侧或右侧PFC，以确定这些损伤对词汇选择的影响。行为测量以及表面EEG信号将确定这些区域在词汇选择中的相对作用，以及当左侧PFC受伤时，右侧PFC是否参与补偿自上而下控制的损失。

项目成果

A comparison of two procedures for verbal response time fractionation.

两种口头反应时间分解程序的比较。

• DOI: 10.3389/fpsyg.2014.01213
• 发表时间: 2014
• 期刊: Frontiers in psychology
• 影响因子: 3.8
• 作者: vanderLinden,Lotje;Riès,StéphanieK;Legou,Thierry;Burle,Borís;Malfait,Nicole;Alario,F-Xavier
• 通讯作者: Alario,F-Xavier

The time course of visual influences in letter recognition.

视觉影响字母识别的时间过程。

• DOI: 10.3758/s13415-015-0400-5
• 发表时间: 2016
• 期刊: Cognitive, affective & behavioral neuroscience
• 作者: Madec,Sylvain;LeGoff,Kévin;Riès,StéphanieK;Legou,Thierry;Rousselet,Guillaume;Courrieu,Pierre;Alario,F-Xavier;Grainger,Jonathan;Rey,Arnaud
• 通讯作者: Rey,Arnaud

How familiarization and repetition modulate the picture naming network.

• DOI: 10.1016/j.bandl.2014.03.010
• 发表时间: 2014-06
• 期刊: BRAIN AND LANGUAGE
• 影响因子: 2.5
• 作者: Llorens, Anais;Trebuchon, Agnes;Ries, Stephanie;Liegeois-Chauvel, Catherine;Alario, F. -Xavier
• 通讯作者: Alario, F. -Xavier

Early and Late Electrophysiological Effects of Distractor Frequency in Picture Naming: Reconciling Input and Output Accounts.

• DOI: 10.1162/jocn_a_00831
• 发表时间: 2015-10
• 期刊: Journal of cognitive neuroscience
• 影响因子: 3.2
• 作者: Riès SK;Fraser D;McMahon KL;de Zubicaray GI
• 通讯作者: de Zubicaray GI