Neural determinents of sound encoding in the aging ear and brain

衰老耳朵和大脑中声音编码的神经决定因素

基本信息

  • 批准号:
    8861116
  • 负责人:
  • 金额:
    $ 37.04万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-04-01 至 2020-03-31
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Age related declines in speech recognition are common for older adults and pose serious consequences for quality of life, which include a variety of poorer health outcomes and decreased economic productivity. Current rehabilitation methods largely depend on amplification to restore speech information and improve speech recognition. However, age-related changes throughout the central and peripheral auditory system may limit the efficacy of intervention strategies and contribute to speech recognition difficulties in older adults. Despite the growing importance of understanding the effects of age on the central auditory system and speech recognition difficulties, studies linking these related phenomena in humans are scarce. The proposed projects use complementary neuroimaging and behavioral methods to identify the structural and metabolic bases for neural declines that impact speech recognition with age. The experiments in Aim 1 examine how age-related deficits in the auditory nerve contribute to dyssynchrony and lead to changes in neural function, structure, and metabolism throughout the central auditory system, and declines in speech recognition. The experiments in Aim 2 characterize how advanced age alters cortical microstructure and contributes to slowed neural processing speed, which is predicted to limit speech envelope encoding and result in poorer speech recognition. By identifying specific neural deficits that contribute to age-related speech recognition declines, the proposed project may lead to improved and more individualized diagnoses and detection of specific age-related auditory processing deficits, and guide the development of more personalized signal processing algorithms for amplification devices and neural based interventions.


项目成果

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KELLY C HARRIS其他文献

KELLY C HARRIS的其他文献

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{{ truncateString('KELLY C HARRIS', 18)}}的其他基金

Neural determinates of cortical plasticity with age and hearing loss
皮质可塑性随年龄和听力损失的神经决定因素
  • 批准号:
    10405478
  • 财政年份:
    2018
  • 资助金额:
    $ 37.04万
  • 项目类别:
Neural determinates of cortical plasticity with age and hearing loss
皮质可塑性随年龄和听力损失的神经决定因素
  • 批准号:
    10163836
  • 财政年份:
    2018
  • 资助金额:
    $ 37.04万
  • 项目类别:
Auditory Temporal Processing in the Aging Ear and Brain
衰老耳朵和大脑的听觉时间处理
  • 批准号:
    7859455
  • 财政年份:
    2009
  • 资助金额:
    $ 37.04万
  • 项目类别:
Auditory Temporal Processing in the Aging Ear and Brain
衰老耳朵和大脑的听觉时间处理
  • 批准号:
    7497534
  • 财政年份:
    2007
  • 资助金额:
    $ 37.04万
  • 项目类别:
Auditory Temporal Processing in the Aging Ear and Brain
衰老耳朵和大脑的听觉时间处理
  • 批准号:
    7676704
  • 财政年份:
    2007
  • 资助金额:
    $ 37.04万
  • 项目类别:
Auditory Temporal Processing in the Aging Ear and Brain
衰老耳朵和大脑的听觉时间处理
  • 批准号:
    8132959
  • 财政年份:
    2007
  • 资助金额:
    $ 37.04万
  • 项目类别:
Auditory Temporal Processing in the Aging Ear and Brain
衰老耳朵和大脑的听觉时间处理
  • 批准号:
    7927050
  • 财政年份:
    2007
  • 资助金额:
    $ 37.04万
  • 项目类别:
Project 3: Pathophysiology of human age-related hearing loss
项目3:人类年龄相关性听力损失的病理生理学
  • 批准号:
    10018502
  • 财政年份:
    1997
  • 资助金额:
    $ 37.04万
  • 项目类别:
Project 3: Pathophysiology of human age-related hearing loss
项目3:人类年龄相关性听力损失的病理生理学
  • 批准号:
    10470233
  • 财政年份:
    1997
  • 资助金额:
    $ 37.04万
  • 项目类别:
Project 3: Pathophysiology of human age-related hearing loss
项目3:人类年龄相关性听力损失的病理生理学
  • 批准号:
    10675672
  • 财政年份:
    1997
  • 资助金额:
    $ 37.04万
  • 项目类别:

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