Sensorimotor Processing of Social Signals

社交信号的感觉运动处理

• 批准号: 8767588
• 负责人: Stephen V Shepherd
• 金额: $ 11.62万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8767588
• 关键词: Address; Amygdaloid structure; Anterior; Anxiety; Area; Autistic Disorder; Behavior; Behavior Control; Behavioral; Brain; Communication; Complex; Couples; Crime; Detection; Development; Discipline; Disease; Dissociation; Drug abuse; Electrodes; Electrophysiology (science); Emotional; Environment; Evaluation; Face; Facial Expression; Faculty; Feedback; Functional Magnetic Resonance Imaging; Functional disorder; Home environment; Human; Image; Individual; Institution; Intervention; Life; Link; Mediating; Mental Depression; Mental Health; Mentors; Methods; Monitor; Monkeys; Motor; Neurosciences; Pathology; Pathway Analysis; Perception; Personal Satisfaction; Primates; Process; Production; Research; Research Training; Rewards; Risk-Taking; Role; Schizophrenia; Signal Transduction; Social Behavior; Social Conditions; Social Interaction; Societies; Stimulus; Structure; System; Techniques; Temporal Lobe; Testing; Training; Universities; Violence; brain pathway; career development; cingulate cortex; cost; design; feeding; gaze; meetings; member; neural circuit; neuromechanism; nonhuman primate; psychologic; public health relevance; relating to nervous system; research facility; response; signal processing; social

DESCRIPTION (as provided by applicant): Though social signaling dysfunction contributes significantly to the human costs of many disorders (e.g. depression, anxiety, autism, schizophrenia), circuit-level neural mechanisms for social evaluation and responsiveness remain poorly understood. Healthy social behavior emerges during complex developmental interactions between individual and environment, but little is known about the circuit-level mechanisms which enable us to thrive in our societies. This project aims to study neural mechanisms of social signal processing, including both signal perception and production, and specifically investigating the role of anterior temporal and anterior cingulate regions in evaluating and responding appropriately to social stimuli. Neural activity in the anterior temporal lobes is associated with social signal perception, and in the anterior cingulate is associated with reward monitoring, behavioral control and spontaneous production of communication signals, but little is known about their interaction during social behavior. The combination of imaging-guided electrophysiology and new multi-electrode recording analysis methods are well-suited to determining the structure and function of these large-scale neural circuits. By monitoring gaze, facial behavior, and neural responses in anterior temporal lobe and anterior cingulate during social signal exchange, this project will relate neural mechanisms of social signal perception to those that govern signal production in real-world interactions. This project will support the grantee in his transition from mentored to independent research on neural mechanisms of social interaction through research training at the Rockefeller University on imaging- guided electrophysiology and network analysis methods. The grantee's career development will be overseen by a committee comprising both the primary mentor and other well-established neuroscience faculty at the home institution and neighboring research facilities. This training plan is designed to meet the need for postgraduate training to integrate neuroscientific, ethological, and psychological approaches to bio behavioral function and development.

描述(由申请人提供)：尽管社会信号传递功能障碍对许多疾病(如抑郁症、焦虑症、自闭症、精神分裂症)的人类成本有很大影响，但对社会评估和反应的电路水平神经机制仍知之甚少。健康的社会行为出现在个人和环境之间复杂的发展互动中，但人们对使我们在社会中茁壮成长的电路水平机制知之甚少。本项目旨在研究社会信号处理的神经机制，包括信号的感知和产生，并特别研究前颞区和前扣带区在评估和适当反应社会刺激方面的作用。前额叶的神经活动 脑叶与社会信号知觉有关，而在前扣带回与 奖励监控、行为控制和自发产生的交流信号，但对它们在社会行为中的相互作用知之甚少。成像引导电生理学和新的多电极记录分析方法的结合非常适合于确定这些大规模神经电路的结构和功能。通过监测社会信号交换过程中前颞叶和前扣带回的凝视、面部行为和神经反应，该项目将把社会信号感知的神经机制与那些在现实世界互动中支配信号产生的神经机制联系起来。该项目将通过在洛克菲勒大学进行成像引导电生理学和网络分析方法的研究培训，支持受赠人从指导到独立研究社会相互作用的神经机制。受赠者的职业发展将由一个委员会监督，该委员会由主要导师和家庭机构和邻近研究机构的其他知名神经科学教师组成。该培训计划旨在满足研究生培训的需要，将神经科学、行为学和心理学方法整合到生物行为功能和发育中。