Sensorimotor Processing of Social Signals

描述（如申请人所提供的）：尽管社会信号传导功能障碍对许多疾病（例如抑郁症、焦虑症、自闭症、精神分裂症）的人类代价有显著贡献，但对社会评价和反应性的回路水平神经机制仍然知之甚少。健康的社会行为在个体与环境之间复杂的发展互动中出现，但对使我们能够在社会中茁壮成长的回路水平机制知之甚少。该项目旨在研究社会信号处理的神经机制，包括信号感知和产生，并特别调查前颞叶和前扣带区域在评估和适当地响应社会刺激中的作用。前颞叶的神经活动 额叶与社会信号感知有关，前扣带回与 奖励监控、行为控制和自发产生的通信信号，但很少有人知道它们在社会行为中的相互作用。 成像引导的电生理学和新的多电极记录分析方法的组合非常适合于确定这些大规模神经回路的结构和功能。通过监测注视，面部行为，以及在社会信号交换过程中前颞叶和前扣带回的神经反应，该项目将社会信号感知的神经机制与现实世界中控制信号产生的神经机制联系起来。该项目将支持受赠人通过在洛克菲勒大学进行成像引导电生理学和网络分析方法的研究培训，从社会互动神经机制的指导研究过渡到独立研究。受助人的职业发展将由一个委员会监督，该委员会由主要导师和家庭机构和邻近研究机构的其他知名神经科学教师组成。该培训计划旨在满足研究生培训的需要，将神经科学，行为学和心理学方法整合到生物行为功能和发展中。

DESCRIPTION (as provided by applicant): Though social signaling dysfunction contributes significantly to the human costs of many disorders (e.g. depression, anxiety, autism, schizophrenia), circuit-level neural mechanisms for social evaluation and responsiveness remain poorly understood. Healthy social behavior emerges during complex developmental interactions between individual and environment, but little is known about the circuit-level mechanisms which enable us to thrive in our societies. This project aims to study neural mechanisms of social signal processing, including both signal perception and production, and specifically investigating the role of anterior temporal and anterior cingulate regions in evaluating and responding appropriately to social stimuli. Neural activity in the anterior temporal lobes is associated with social signal perception, and in the anterior cingulate is associated with reward monitoring, behavioral control and spontaneous production of communication signals, but little is known about their interaction during social behavior. The combination of imaging-guided electrophysiology and new multi-electrode recording analysis methods are well-suited to determining the structure and function of these large-scale neural circuits. By monitoring gaze, facial behavior, and neural responses in anterior temporal lobe and anterior cingulate during social signal exchange, this project will relate neural mechanisms of social signal perception to those that govern signal production in real-world interactions. This project will support the grantee in his transition from mentored to independent research on neural mechanisms of social interaction through research training at the Rockefeller University on imaging- guided electrophysiology and network analysis methods. The grantee's career development will be overseen by a committee comprising both the primary mentor and other well-established neuroscience faculty at the home institution and neighboring research facilities. This training plan is designed to meet the need for postgraduate training to integrate neuroscientific, ethological, and psychological approaches to bio behavioral function and development.