Measurement of health and disability trends, compression of morbidity aging study

说明(申请人提供)：在对一般人群样本中的老年人进行研究时，将生物标记物数据与社会经济、健康和福祉数据相结合的必要性日益被认为是一项有价值的研究成果，这种研究正在世界上许多国家实施。为了解人口健康和疾病的流行病学而进行的大规模纵向队列研究也被视为纳入遗传措施的一种机制，以增加我们对基因和环境在影响人类健康和福祉方面的作用的了解。拟议的研究通过将DNA样本的收集以及在世界卫生组织的全球老龄化和成人健康研究(SAGE)及其伴随的艾滋病毒感染者研究(SAGE-HIV研究)以及关于受健康和人口监测的人口研究(SAGE-INDEPTH研究)的两波数据收集过程中产生的丰富表型相结合，解决了其中许多问题。总体而言，这些SAGE研究目前正在收集撒哈拉以南非洲国家约25,000名社区居住的老年人的数据。对第二波和第三波中的圣人队列的后续采访每隔两年进行一次。SAGE HIV子研究的两波数据现已公布，另一轮访谈计划于2015年(第三波)和2017年(第四波)进行。SAGE-INDEPTH分研究后续行动(第2波)将于2014年实施。全面的健康衡量标准，再加上一系列生物标志物的纳入，为研究基因与环境之间相互作用的复杂性以及非临床老年非洲人口的健康和疾病提供了前所未有的机会。在南非的人类遗传与非洲健康(H3A)方案下与AWI-Gen合作中心的合作将带来协同效应，将最先进的基因分析专业知识与流行病学专业知识结合起来。这项拟议研究的数据将对了解类似老年人口的健康和福祉有直接影响 在美国，尤其是那些来自较低社会经济阶层和少数群体的人。这项研究的数据将使用可与其他国际老龄化研究相媲美的健康指标，如美国健康和退休研究。这项研究的所有匿名微观数据将根据国际标准与所有元数据一起存档，并提供给研究人员。

DESCRIPTION (provided by applicant): The need to combine biomarker data with socioeconomic, health and well-being data in studies of older adults from general population samples is being increasingly recognized as a valuable research good, and such studies are being implemented in many countries around the world. Large scale longitudinal cohort studies to understand the epidemiology of population health and disease are also being considered as a mechanism to incorporate genetic measures to increase our understanding of the role of genes and environment in influencing human health and well-being. The proposed study addresses many of these issues by combining the collection of DNA samples along with richly textured phenotypes generated over two waves of data collection of the World Health Organization's Study on Global AGEing and Adult Health (SAGE), its accompanying studies in HIV affected respondents (the SAGE-HIV studies) and the studies on populations under health and demographic surveillance (the SAGE- INDEPTH studies). In total, these SAGE studies are currently collecting data on a cohort of about 25,000 community-dwelling older adults across countries in sub-Saharan Africa. Follow-up interviews for the SAGE cohorts in Waves 2 and 3 are taking place at two year intervals. Two waves of data from the SAGE HIV sub-study are available with another round of interviews planned for 2015 (Wave 3) and 2017 (Wave 4). The SAGE- INDEPTH sub-study follow-up (Wave 2) will be implemented in 2014. Comprehensive measures of health coupled with the inclusion of an array of biomarkers provide an unprecedented opportunity to study the complex nature of interactions between genes and the environment and resulting health and disease in non-clinical older African populations. Collaborations with the AWI-Gen Collaborative Centre under the Human Heredity and Health in Africa (H3A) programme in South Africa will bring synergies that combine expertise in state-of-the-art genetic analysis with expertise in epidemiology. Data from the proposed study will have direct implications for understanding the health and well- being of similar older adult populations in the US, especially those from lower socioeconomic classes and minority populations. Data from the study will use health measures that are comparable to other international studies of aging, like the US Health and Retirement Study. All anonymized microdata from the study will be archived according to international standards along with all metadata and made available to researchers.