Measurement of health and disability trends, compression of morbidity aging study

描述（由申请人提供）：从一般人群样本中对老年人进行研究，将生物标志物数据与社会经济、健康和福祉数据结合起来的需求日益被认为是一项有价值的研究成果，世界上许多国家正在实施此类研究。了解人口健康和疾病流行病学的大规模纵向队列研究也被认为是一种纳入遗传措施的机制，以增加我们对基因和环境在影响人类健康和福祉方面的作用的理解。拟议的研究通过将DNA样本的收集与世界卫生组织全球老龄化和成人健康研究（SAGE）的两波数据收集所产生的丰富的表型相结合，解决了其中的许多问题，这两波数据收集是在受艾滋病毒影响的受访者中进行的附带研究（SAGE -HIV研究）以及在健康和人口监测下进行的人口研究（SAGE - INDEPTH研究）中进行的。总的来说，这些SAGE研究目前正在收集撒哈拉以南非洲各国约25,000名社区居住老年人的数据。二期和三期SAGE队列的后续访谈每两年进行一次。SAGE艾滋病毒子研究的两波数据可供使用，并计划在2015年（第三波）和2017年（第四波）进行另一轮访谈。SAGE- INDEPTH子研究随访（第二波）将于2014年实施。综合健康措施加上纳入一系列生物标记物，为研究基因与环境之间相互作用的复杂性以及由此导致的非洲非临床老年人口的健康和疾病提供了前所未有的机会。与南非非洲人类遗传和健康（H3A）方案下的非洲遗传研究所- gen合作中心的合作将带来协同效应，将最先进的遗传分析专业知识与流行病学专业知识结合起来。从拟议的研究数据将有直接的含义，了解健康和福祉的类似老年成人人口

DESCRIPTION (provided by applicant): The need to combine biomarker data with socioeconomic, health and well-being data in studies of older adults from general population samples is being increasingly recognized as a valuable research good, and such studies are being implemented in many countries around the world. Large scale longitudinal cohort studies to understand the epidemiology of population health and disease are also being considered as a mechanism to incorporate genetic measures to increase our understanding of the role of genes and environment in influencing human health and well-being. The proposed study addresses many of these issues by combining the collection of DNA samples along with richly textured phenotypes generated over two waves of data collection of the World Health Organization's Study on Global AGEing and Adult Health (SAGE), its accompanying studies in HIV affected respondents (the SAGE-HIV studies) and the studies on populations under health and demographic surveillance (the SAGE- INDEPTH studies). In total, these SAGE studies are currently collecting data on a cohort of about 25,000 community-dwelling older adults across countries in sub-Saharan Africa. Follow-up interviews for the SAGE cohorts in Waves 2 and 3 are taking place at two year intervals. Two waves of data from the SAGE HIV sub-study are available with another round of interviews planned for 2015 (Wave 3) and 2017 (Wave 4). The SAGE- INDEPTH sub-study follow-up (Wave 2) will be implemented in 2014. Comprehensive measures of health coupled with the inclusion of an array of biomarkers provide an unprecedented opportunity to study the complex nature of interactions between genes and the environment and resulting health and disease in non-clinical older African populations. Collaborations with the AWI-Gen Collaborative Centre under the Human Heredity and Health in Africa (H3A) programme in South Africa will bring synergies that combine expertise in state-of-the-art genetic analysis with expertise in epidemiology. Data from the proposed study will have direct implications for understanding the health and well- being of similar older adult populations in the US, especially those from lower socioeconomic classes and minority populations. Data from the study will use health measures that are comparable to other international studies of aging, like the US Health and Retirement Study. All anonymized microdata from the study will be archived according to international standards along with all metadata and made available to researchers.