Vestibular Migraine Investigated with Psychophysical and Oculomotor Tests

描述（由申请人提供）：前庭性偏头痛（VM），定义为前庭症状，如由偏头痛机制而不是其他内耳或大脑异常产生的眩晕，是一种常见的致残性问题。尽管其频率，VM的病理生理学仍然不确定，没有具体的视力，姿势，或感知缺陷已被描述在这种疾病。本研究采用定量的心理物理学和眼科学测试来研究VM的病理生理学，其基本假设是半规管提供的旋转信息和重力惯性信息 脑合成异常。将进行三个相互关联的实验来研究这一假设。在VM受试者和对照组（正常受试者、无头晕的偏头痛患者、无偏头痛的头晕患者）中，我们将测量前庭刺激对感知阈值（SA 1）、感知倾斜和平移幅度（SA 2）以及眼动反应（SA 3）的影响。感知和眼动反应的预测，以显示在大脑中增强的耳道-耳石相互作用的证据，使他们增强时，这两个线索是一致的（如滚动倾斜），被抑制时，线索冲突（如离心），和正常时，运河和耳石被激活隔离。这些预测得到了为支持这一提议而收集的大量初步数据的支持。这项研究将有助于阐明 偏头痛引起的前庭症状的机制对于开发有助于识别VM的诊断测试至关重要，也可以提供科学依据 来治疗这种疾病

DESCRIPTION (provided by applicant): Vestibular migraine (VM), defined as vestibular symptoms such as vertigo generated by migraine mechanisms rather than other inner ear or brain abnormalities, is a common and disabling problem. Despite its frequency, the pathophysiology of VM remains uncertain and no specific oculomotor, postural, or perceptual defect has been described in this disorder. This proposal investigates the pathophysiology of VM using quantitative psychophysical and oculomotor tests with the underlying hypothesis that the rotational information provided by the semicircular canals and the gravito-inertial information provided by the otolith organs are synthesized abnormally by the brain in VM. Three inter-related experiments will be performed to investigate this hypothesis. In VM subjects and controls groups (normal subjects, migraine patients without dizziness, dizziness patients without migraine), we will measure the effects of vestibular stimulation on perceptual thresholds (SA1), perceived magnitude of tilt and translation (SA2), and eye movement responses (SA3). Perceptual and eye movement responses are predicted to show evidence of enhanced canal-otolith interactions in the brain such that they are augmented when these two cues are congruent (e.g. roll tilt), are inhibited when the cues conflict (e.g. centrifugation), and are noral when the canals and otoliths are activated in isolation. These predictions are supported by the extensive preliminary data collected to support this proposal. This research will help to elucidate the mechanisms responsible for vestibular symptoms caused by migraine, could be critical for developing diagnostic tests that help to identify VM, and could also provide a scientific rationale for treating patients with this disorder.