OCULAR PROPRIOCEPTION AND EYE/HAND MOTOR CONTROL

这项提案的总体目标是调查如何获得 视网膜和视网膜外眼球运动信号用于控制眼睛 运动和眼手协调，在视觉空间的编码中， 在正常和病理环境下。具体地说，目标是 理解眼睛本体感觉在即时反应中的作用 眼动和视觉引导肢体的直线和自适应控制 动静。将解决三个具体的假设，涉及 眼本体感觉的潜在即时和长期功能：1) 本体感觉有助于眼眶的即时在线编码 眼睛位置2)本体感觉参与适应过程， 确保眼眶位置的准确内部表示；3) 本体感觉不会影响在线信号的使用 眼跳脉冲产生的反馈控制。 这些假说将在恒河猴身上通过测量和测量来研究。 比较以自我为中心和以眼球为中心的空间定位(如 视觉引导的指点)和动眼功能(静态眼球对齐 和扫视指标)，在范例中。视觉输入被改变，并且 本体感受性传入被修改或消除。具体来说， 单眼和双眼去传入对眼和眼神经功能的影响 肢体运动，将在正常猴子的被动眼睛中进行研究 偏差、棱镜适应、参数眼跳适应和 对单侧眼肌麻痹的适应。眼球运动将会是 用磁力搜索线圈法测量；指点将被量化 配有电脑触摸屏。 这项拟议的研究将有助于阐明眼睛所起的作用 眼睛和肢体运动控制以及视觉空间中的本体感觉 感知力。潜在的医疗保健影响包括在 了解和治疗各种视觉、眼球运动和 骨骼运动障碍，如斜视和肢体步态共济失调 与眼肌麻痹有关。研究方案整合了 运动控制的实验和理论方法的培训， 相关障碍的临床经验，医学生和 常驻教学。

The overall objective of this proposal is to investigate how the available retinal and extraretinal oculomotor signals are used in the control of eye movements and eye-hand coordination, and in the encoding of visual space, in normal and pathological settings. Specifically, the aim is to understand the role played by ocular proprioception in the immediate on- line and adaptive control of eye movements and visually-guided limb movements. Three specific hypotheses will be addressed, concerning potential immediate and long-term functions of ocular proprioception: 1) proprioception contributes to the immediate on-line encoding of orbital eye position 2) proprioception participates in the adaptive processes that ensure an accurate internal representation of orbital eye position; 3) proprioception does not contribute to the on-line signal used in the feedback control of saccadic pulse generation. These hypotheses will be investigated in rhesus monkeys by measuring and comparing egocentric and oculocentric spatial localization (as manifest in visually-guided pointing) and oculomotor function (static ocular alignment and saccade metrics), in paradigms where. visual inputs are altered, and where proprioceptive afference is modified or eliminated. Specifically, the effect of unilateral and bilateral ocular deafferentation on eye and limb movements, will be investigated in normal monkeys, during passive eye deviation, prism adaptation, parametric saccadic adaptation, and adaptation to unilateral ocular muscle palsies. Eye movements will be measured with the magnetic search coil method; pointing will be quantified with a computer touch- screen. The proposed research will help to elucidate the role played by ocular proprioception in eye and limb motor control, and in visuo-spatial perception. Potential health care implications include advances in the understanding and therapy of a variety of visual, oculomotor, and skeletal-motor disorders, such as strabismus and the limb- gait ataxia associated with ocular muscle palsies. The research proposal integrates training in experimental and theoretical approaches to motor control, clinical experience with related disorders, and medical student and resident teaching.