1st World Congress on Tourette Syndrome and Tic Disorders

第一届抽动秽语综合征和抽动障碍世界大会

• 批准号: 9034342
• 负责人: Jeremiah M Scharf
• 金额: $ 1万
• 依托单位: TOURETTE ASSOCIATION OF AMERICA, INC.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9034342
• 关键词: Adolescence; Advocacy; Advocate; Affect; Area; Attention deficit hyperactivity disorder; Awareness; Basal Ganglia; Basic Science; Canada; Caring; Child; Childhood; Chronic; Clinical; Clinical Research; Collaborations; Communication; Congresses; Development; Diagnosis; Discipline; Disease; Education; England; Environmental Risk Factor; Etiology; Europe; European; Faculty; Fostering; Functional disorder; Funding; Future; Gilles de la Tourette syndrome; Individual; International; Interneurons; Investigation; Knowledge; Lead; London; Morbidity - disease rate; Motor Tics; National Institute of Mental Health; National Institute of Neurological Disorders and Stroke; Neurodevelopmental Disorder; Obsessive-Compulsive Disorder; Pathogenesis; Patients; Population; Request for Applications; Research; Research Infrastructure; Research Personnel; Resources; Role; Severities; Societies; Susceptibility Gene; Tic disorder; Time; United States National Institutes of Health; Vocal Tics; Waxes; Work; burden of illness; clinical care; disability; frontal lobe; genetic epidemiology; improved; interest; meetings; neuroimaging; neurophysiology; neuropsychiatry; non-genetic; novel; novel strategies; outreach; phenomenological models; public health relevance; social; symposium; treatment strategy

 DESCRIPTION (provided by applicant): Tourette Syndrome (TS) is a developmental neuropsychiatric disorder characterized by persistent (chronic) motor and vocal tics that begin in childhood and typically wax and wane in severity over time. TS often co- occurs with other neuropsychiatric disorders such as obsessive-compulsive disorder (OCD) and attention- deficit hyperactivity disorder (ADHD), and together they frequently cause significant social, academic and vocational morbidity in childhood and adolescence, and in severe cases can result in lifelong disability. Once considered to be rare, TS is now believed to occur in 3-8 per 1000 children (0.3-0.8%). Despite significant research advances in TS epidemiology, genetics, neurophysiology and neuroimaging, the underlying pathophysiology of tics and TS is still obscure. A major obstacle to developing an integrated understanding of TS is the absence of a regular forum for investigators working in different areas of TS research to convene together, to exchange ideas, and to establish new, inter-disciplinary collaborations that may result in novel approaches to studying the disorder and therefore lead to new treatments. This application requests funding for partial support for the 1st World Congress on Tourette Syndrome and Tic Disorders to be held in London, England from June 24 - 26, 2015. Given the increased awareness and interest in TS and related disorders across both the US and Europe, TSA has partnered with Tourette Action - UK and the European Society for the Study of Tourette Syndrome (ESSTS) to present a truly global perspective on the most recent advances that have been made in treatment strategies and research in TS and related disorders. As such, the 1st World Congress on Tourette Syndrome and Tic Disorders will supersede the 5 previous International Scientific Symposia on Tourette Syndrome that took place between 1981 and 2009 and were co- sponsored by TSA, NINDS, NIMH and ORD. Holding this congress in Europe will maximize cross-cultural discussion between US and European TS experts. In addition, the congress will serve as a highly effective venue for international communication of clinicians and researchers working on TS that will build global partnerships, pool resources and set the agenda for future TS research efforts and improved clinical care.

 描述（由申请人提供）：抽动秽语综合症（TS）是一种发育性神经精神疾病，其特征是持续（慢性）运动和发声抽动，始于童年，并且通常随着时间的推移，严重程度逐渐减弱。 TS 常常与其他神经精神疾病同时发生，例如强迫症 (OCD) 和注意力缺陷多动障碍 (ADHD)，它们共同导致儿童和青少年时期显着的社会、学业和职业发病率，严重时可能导致终身残疾。一度被认为罕见的 TS 现在被认为每 1000 名儿童中有 3-8 人患有 TS（0.3-0.8%）。尽管 TS 流行病学、遗传学、神经生理学和神经影像学方面的研究取得了重大进展，但抽动症和 TS 的潜在病理生理学仍然不清楚。发展对 TS 的综合理解的一个主要障碍是缺乏一个定期论坛，供从事 TS 研究不同领域工作的研究人员聚集在一起，交流想法，并建立新的跨学科合作，这可能会产生研究该疾病的新方法，从而带来新的治疗方法。本申请请求为将于 2015 年 6 月 24 日至 26 日在英国伦敦举行的第一届抽动秽语综合症和抽动障碍世界大会提供部分支持。鉴于美国和欧洲对抽动秽语综合征及相关疾病的认识和兴趣不断增强，TSA 与英国抽动秽语行动组织和欧洲抽动秽语综合症研究学会 (ESSTS) 合作，以真正的全球视角展示在抽动秽语综合症方面取得的最新进展。 TS 及相关疾病的治疗策略和研究。因此，第一届抽动秽语综合症和抽动障碍世界大会将取代 1981 年至 2009 年间举行的第五届抽动秽语综合症国际科学研讨会，该研讨会由 TSA、NINDS、NIMH 和 ORD 共同主办。在欧洲举办这次会议将最大限度地促进美国和欧洲 TS 专家之间的跨文化讨论。此外，大会将成为从事 TS 工作的临床医生和研究人员进行国际交流的高效场所，从而建立全球合作伙伴关系、汇集资源并为未来 TS 研究工作和改善临床护理制定议程。

项目成果

TS-EUROTRAIN: A European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome.

• DOI: 10.3389/fnins.2016.00384
• 发表时间: 2016
• 期刊: Frontiers in neuroscience
• 影响因子: 4.3
• 作者: Forde NJ;Kanaan AS;Widomska J;Padmanabhuni SS;Nespoli E;Alexander J;Rodriguez Arranz JI;Fan S;Houssari R;Nawaz MS;Rizzo F;Pagliaroli L;Zilhäo NR;Aranyi T;Barta C;Boeckers TM;Boomsma DI;Buisman WR;Buitelaar JK;Cath D;Dietrich A;Driessen N;Drineas P;Dunlap M;Gerasch S;Glennon J;Hengerer B;van den Heuvel OA;Jespersgaard C;Möller HE;Müller-Vahl KR;Openneer TJ;Poelmans G;Pouwels PJ;Scharf JM;Stefansson H;Tümer Z;Veltman DJ;van der Werf YD;Hoekstra PJ;Ludolph A;Paschou P
• 通讯作者: Paschou P