Sleep, Energetic Behaviors, and Adolescent Obesity during the Transition from Middle to High School

初中到高中过渡期间的睡眠、精力充沛的行为和青少年肥胖

• 批准号: 8891779
• 负责人: Jonathan Andrew Mitchell
• 金额: $ 13.17万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8891779
• 关键词: 14 year old; Academy; Address; Adolescence; Adolescent; Adolescent Behavior; Adult; Affect; American; American Heart Association; Animal Model; Area; Behavior; Body Composition; Body mass index; Bone Development; Carbohydrates; Cardiovascular Diseases; Childhood; Cross-Sectional Studies; Data; Data Analyses; Development; Diet; Dietary intake; Dual-Energy X-Ray Absorptiometry; Eating; Energy Intake; Enrollment; Epidemiologist; Epidemiology; Event; Fatigue; Fatty acid glycerol esters; Food; Future; Genes; Genetic; Genetic screening method; Genomics; Genotype; Goals; Growth; Health; Healthy People 2020; Hip region structure; Homeostasis; Hormones; Hour; Hypothalamic structure; Intake; K-Series Research Career Programs; Knowledge; Laboratories; Lead; Life Style; Longevity; Longitudinal Studies; Low Prevalence; Measurement; Measures; Medicine; Mentors; Methodology; Methods; Modeling; Morbidity - disease rate; Obesity; Participant; Patient Self-Report; Pattern; Pediatric Hospitals; Pennsylvania; Philadelphia; Physical activity; Polysomnography; Predisposition; Prevalence; Prevention; Proteins; Protocols documentation; Public Health; Recruitment Activity; Research; Research Project Grants; Resources; Risk Factors; Rotation; Sampling; Senior Scientist; Series; Sex Behavior; Single Nucleotide Polymorphism; Sleep; Societies; Time; Training; Training Activity; Universities; Variant; Visceral; Visit; Work; Wrist; actigraphy; aged; base; behavior change; behavior test; biobehavior; bone mass; career; eighth grade; experience; follow-up; gene environment interaction; high school; medical schools; meetings; member; mortality; ninth grade; nutrition; obesity in children; obesity prevention; obesity risk; programs; public health relevance; research study; sedentary

 DESCRIPTION (provided by applicant): Jonathan Mitchell is an epidemiologist whose research aims to explain variations in childhood growth patterns. His long-term career goal is to lead a program of biobehavioral research to test how behaviors and genes combine to affect body composition and the development of obesity during adolescence. His work will help to inform childhood obesity prevention and promote healthy bone development. This career development award will provide him with training in sleep and he will develop expert knowledge on the integrated relationships between sleep, dietary intakes and physical activity in childhood. He will also receive training on the genetics of childhood obesity and bone mass, and this will enable him to lead gene-environment interaction studies. Finally, he will receive expert training on the methodologies used to measure body composition in the lab setting so that he can specifically estimate adiposity and bone mass in his research studies. His development in these areas will be achieved through a series of training activities and a research project, guided by an interdisciplinary team of senior scientists with expertise in sleep, genetics, nutrition, physicl activity, and body composition. He will complete coursework and attend seminars at the University of Pennsylvania that will cover sleep, nutrition, and obesity research. He will collaborate with members of his mentoring team to complete laboratory rotations and independent studies on sleep measurement, body composition measurement, and the genetics of body composition. He will complete short courses that cover physical activity research and longitudinal data analysis, and he will attend annual scientific meetings hosted by the American Academy of Sleep Medicine (SLEEP), the American Heart Association (Epidemiology and Prevention/Lifestyle and Cardiometabolic Health [EPI/Lifestyle]), and the Obesity Society (Obesity Week). He will lead a research project that will use resources at the University of Pennsylvania, Perelman School of Medicine and the Children's Hospital of Philadelphia (CHOP). The research project aims to investigate the association between sleep, adolescent obesity and energy intake and physical activity. He will recruit a sample of 100 healthy adolescents aged 13 to 14 (8th grade) at baseline and will re-assess these adolescents at 1-year follow-up (9th grade. The participants have already been genotyped for single nucleotide polymorphisms (SNPs), representing obesity susceptibility loci, at the Center for Applied Genomics at CHOP. At both time points, he will provide each participant with two accelerometers; one will be worn for 24 hours per day for 2-weeks on the wrist to estimate total sleep time (TST). The second will be worn on the hip during waking hours for 2-weeks to estimate time spent in moderate-to-vigorous physical activity (MVPA) and sedentary behavior (SB). During the 2-week wear periods trained Nutrition Core staff will call each participant on three occasions to record foods consumed in the past 24 hours; these data will be used to estimate energy intakes. Each participant will visit the CTRC Nutrition Core to have his or her fat mass estimated by dual energy X-ray absorptiometry (DXA). He hypothesizes that: 1) declines in TST will be associated with higher fat mass, 2) declines in TST will be associated with increased energy intake, and 3) declines in TST will be associated with less time spent in MVPA and more time spent in SB. This longitudinal study will provide the experience and necessary pilot and feasibility data to support a larger R01 study of the effects of sleep, diet and physical activity on adiposity changes during adolescence.

 描述(申请人提供)：乔纳森·米切尔是一名流行病学家，他的研究旨在解释儿童成长模式的变化。他的长期职业目标是领导一个生物行为研究项目，以测试行为和基因如何结合在一起，影响青少年时期的身体成分和肥胖的发展。他的工作将有助于为儿童肥胖预防提供信息，并促进健康的骨骼发育。这项职业发展奖将为他提供睡眠方面的培训，他将发展关于睡眠、饮食摄入量和童年体育活动之间综合关系的专业知识。他还将接受儿童肥胖和骨量遗传学方面的培训，这将使他能够领导基因与环境相互作用的研究。最后，他将接受关于在实验室环境中测量身体成分的方法的专家培训，以便他可以在研究中具体估计肥胖和骨量。他在这些领域的发展将通过一系列培训活动和一个研究项目来实现，该项目由一个由具有睡眠、遗传学、营养学、体力活动和身体成分专业知识的资深科学家组成的跨学科团队指导。他将完成课程作业，并参加宾夕法尼亚大学的研讨会，这些研讨会将涵盖睡眠、营养和肥胖研究。他将与他的指导团队成员合作，完成实验室轮换和关于睡眠测量、身体成分测量和身体成分遗传学的独立研究。他将完成涵盖体力活动研究和纵向数据分析的短期课程，并将参加由美国睡眠医学学会(睡眠)、美国心脏协会(流行病学与预防/生活方式和心脏代谢健康[EPI/Lifestyle])和肥胖协会(肥胖周)主办的年度科学会议。他将领导一个研究项目，利用宾夕法尼亚大学、佩雷尔曼医学院和费城儿童医院(CHOP)的资源。该研究项目旨在调查睡眠、青少年肥胖与能量摄入和体力活动之间的关系。他将招募100名年龄在13至14岁(8年级)的健康青少年作为样本，并在1年后(9年级)对这些青少年进行重新评估。参与者已经在CHOP的应用基因组学中心接受了代表肥胖易感基因座的单核苷酸多态(SNPs)的基因分型。在这两个时间点，他将为每位参与者提供两个加速计；其中一个将每天24小时佩戴在手腕上，为期两周，以估计总睡眠时间(TST)。第二个将在醒着的时间里戴在臀部，持续两周，以估计花在中等到剧烈的体力活动(MVPA)和久坐行为(SB)上的时间。在为期两周的穿戴期间，训练有素的营养核心工作人员将在三个场合给每位参与者打电话，记录他们在过去24小时内摄入的食物；这些数据将用于估计能量摄入量。每个参与者都将访问CTRC营养核心，以获得他或她的脂肪 用双能X射线吸收法(DXA)估计的质量。他假设：1)TST的下降将与更高的脂肪质量有关，2)TST的下降将与能量摄入的增加有关，3)TST的下降将与花在MVPA上的时间减少和花在SB上的时间更多有关。这项纵向研究将提供经验以及必要的试点和可行性数据，以支持更大规模的R01睡眠、饮食和身体影响研究 青春期肥胖症的活动性变化。