Evaluating Vocal Fold Tissue Structure and Vibratory Stress

评估声带组织结构和振动应力

• 批准号: 9051471
• 负责人: Erin E Devine
• 金额: $ 3.67万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-31 至 2017-08-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9051471
• 关键词: Absenteeism at work; Accounting; Acoustics; Adult; Affect; American; Anisotropy; Behavior; Benign; Biomechanics; Caring; Chronic Disease; Chronic Obstructive Airway Disease; Clinical; Clinical Management; Collagen; Computer Simulation; Computers; Congestive Heart Failure; Cyst; Data; Dehydration; Development; Disease; Dysphonia; Elements; Evaluation; Evaluation Studies; Extracellular Matrix; Fatigue; Fiber; Generations; Goals; Gray unit of radiation dose; Health Care Costs; Hydration status; Image; Impairment; Inflammation; Intercellular Fluid; Intervention; Knowledge; Lamina Propria; Larynx; Laser Scanning Microscopy; Lead; Lesion; Liquid substance; Measures; Mechanics; Medical; Methods; Modeling; Movement; Nodule; Normal tissue morphology; Oryctolagus cuniculus; Patients; Phase; Phonation; Physiological; Physiology; Play; Polyps; Property; Quality of life; Recommendation; Relaxation; Research; Resistance; Role; Rupture; Solid; Spatial Distribution; Speed; Stress; Structure; Swelling; Therapeutic; Therapeutic Intervention; Tissues; Trauma; Ultrasonography; Voice; Voice Disorders; Wages; Weight-Bearing state; Work; cost; disability; elastography; experience; improved; interest; kinematics; novel; pressure; public health relevance; second harmonic; socioeconomics; soft tissue; trend; vibration; vocal cord

 DESCRIPTION (provided by applicant): Benign glottic lesions are generally believed to result from mechanical trauma to the vocal folds, and affect million of working Americans. However, the extent of trauma and loading conditions that lead to structural damage, inflammation, and ultimately lesions such as nodules, polyps or cysts, is not well defined. In order to better understand the loading conditions and vocal behaviors that can lead to damage, greater understanding of material properties, stress distributions, and the resulting fiber damage is necessary. Vocal fold tissues experience a type of loading that is unique among soft tissues of the body. They undergo vibration and are loaded in the axial and transverse directions in tension, compression and shear, while most soft tissues are loaded either in tension or compression in a single direction. Because of this difference in load bearing, the structure (extracellular matrix fiber arrangement) and material property trends of the vocal folds differs from other softer tissues, making study of the vocal fold tissue properties critical for understanding the mechanism of structural damage leading to lesions. The overall goal of this proposal is to evaluate the material properties of the vocal folds, the stress experienced during phonation under varying hydration, elongation and subglottal pressure conditions, and the resulting structural damage to the tissue. The results will potentially describe the forces of vibration that result in tissue damage- either fatigue damage or fiber rupture. Methods of material property estimation and structural damage evaluation are novel and will contribute to knowledge about vocal fold tissue properties. Knowledge gained from this research is essential for a more complete understanding of clinical management of voice disorders. The approach to this research will involve three specific aims. The first aim will focus on characterizing vocal fod material properties. It will employ acousto-elastography, which is a novel measure of the tissue acoustic properties that is linearly related to strain and nonlinearly related to tissue stress. Th results of these methods will be useful for establishing the effects of dehydration on tissue stiffness and informing computer model parameters. The second aim will focus on finite element modeling of vocal fold vibration and the resulting interstitial fluid dynamics and stress distributions. Elongation, subglottal pressure, hydration and stiffness will be varied and resultin stresses evaluated. The third aim will focus on excised studies and evaluation of tissue damage under varying subglottal pressure, hydration and elongation phonation challenges. The potential long term implications of this work are (1) better characterizing the vocal behaviors that might lead to lesions to inform therapeutic recommendations and (2) a better understanding of the mechanism of lesion formation to inform interventions.

 描述（由申请人提供）：良性声门病变通常被认为是由声带的机械创伤引起的，影响了数百万美国工人。然而，导致结构损伤、炎症和最终病变（如结节、息肉或囊肿）的创伤程度和负荷条件尚未明确。为了更好地了解可能导致损伤的载荷条件和声音行为，有必要更好地了解材料特性，应力分布以及由此产生的纤维损伤。声带组织经历一种在身体软组织中独特的负荷。它们经受振动并在轴向和横向方向上承受拉伸、压缩和剪切载荷，而大多数软组织在单一方向上承受拉伸或压缩载荷。由于这种承重的差异，声带的结构（细胞外基质纤维排列）和材料特性趋势与其他软组织不同，因此研究声带组织特性对于理解导致病变的结构损伤机制至关重要。该提案的总体目标是评估声带的材料特性，在不同的水合作用、伸长和声门下压力条件下发声期间所经历的应力，以及对组织造成的结构损伤。结果将潜在地描述导致组织损伤的振动力-疲劳损伤或纤维断裂。材料性能估计和结构损伤评估的方法是新颖的，将有助于了解声带组织的属性。从这项研究中获得的知识对于更全面地了解嗓音疾病的临床管理至关重要。这项研究的方法将涉及三个具体目标。第一个目标将集中在表征声乐饲料材料属性。它将采用声弹性成像，这是一种新的测量组织的声学特性，是线性相关的应变和非线性相关的组织应力。这些方法的结果将有助于建立脱水对组织硬度的影响，并为计算机模型参数提供信息。第二个目标将集中在声带振动的有限元建模和由此产生的间质流体动力学和应力分布。伸长、声门下压、水合作用和刚度将发生变化，并对产生的应力进行评估。第三个目标将集中在切除的研究和评估组织损伤下，不同的声门下压力，水化和伸长发声的挑战。这项工作的潜在长期影响是（1）更好地表征可能导致病变的发声行为，以提供治疗建议;（2）更好地了解病变形成的机制，以提供干预措施。