2_2 Treatment of Suicidal and Self_Injurous Adolescents with Emotional Dysregula

2_2 情绪失调的自杀和自残青少年的治疗

• 批准号: 8924875
• 负责人: Joan Rosenbaum Asarnow
• 金额: $ 10.46万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8924875
• 关键词: 17 year old; Address; Adolescent; Adult; Adverse event; Area; Behavioral; Borderline Personality Disorder; California; Cause of Death; Characteristics; Clinical; Clinical Trials; Collaborations; Conflict (Psychology); Coping Skills; Data; Dialectical behavior therapy; Dropout; Effectiveness; Emergency department visit; Emotional; Emotions; Event; Family; Family Relationship; Foundations; Frequencies; Health Insurance Portability and Accountability Act; Hospitalization; Hour; Incidence; Individual; Informed Consent; Inpatients; Intervention; Leadership; Legal; Life; Los Angeles; Maintenance; Mediating; Mediator of activation protein; Medical; Medication Management; Monitor; Online Systems; Outcome; Outpatients; Parents; Participant; Personality Traits; Privacy; Quality of life; Research; Resources; Risk; Risk Factors; Safety; Schools; Self-Injurious Behavior; Severities; Site; Stressful Event; Suicide; Suicide attempt; Supervision; Supportive care; Teenagers; Telephone; Testing; Theoretical model; Time; Training; Universities; Washington; Work; alternative treatment; base; clinical care; cost; cost effective; cost effectiveness; effective therapy; emotion dysregulation; emotion regulation; follow-up; functional outcomes; high risk; improved; improved functioning; meetings; non-suicidal self injury; peer; programs; psychosocial; quality assurance; randomized trial; reducing suicide; skills; suicidal; suicidal adolescent; suicidal behavior; suicidal risk; symposium; teacher; trait

DESCRIPTION (provided by applicant): The long term aim of our research is to develop and evaluate effective treatments for adolescents at high risk for suicide that will reduce suicidal and self-injurious behaviors as well as improve functioning and the quality of life of teens and their families. The primary aim of the research proposed here is to evaluate the efficacy of dialectical behavior therapy (DBT) for adolescents by comparing it to a combined individual and group supportive therapy control condition (I/GST) chosen specifically to maximize internal validity. Subjects will be 170 teens 13-17 years old with borderline personality traits referred to treatment due to high risk for suicide. Outcome targets include reduced frequency and severity of suicidal behaviors, especially suicide attempts, inpatient or ER treatment for suicidality, increased maintenance in and compliance with treatment, and enhanced functioning across multiple domains. DBT has an empirical track record with adults of reducing the incidence, frequency and medical risk of suicide attempts and non-suicidal self-injuries among individuals meeting criteria for borderline personality disorder (BPD). However, although DBT is widely used with suicidal adolescents, particularly those with difficulties characteristic of BPD such as poor emotion regulation and impulse control, no randomized trial of DBT with adolescents has been conducted. Thus, although non- randomized trials suggest effectiveness, without a randomized trial we simply do not know whether DBT for adolescents is efficacious or not. Given the severity of the problem and the lack of alternative treatments for high risk adolescents, addressing this question is important. The second aim of this research is to analyze mediators of reduced suicidal and self-injurious behaviors in adolescents. DBT is based on a theoretical model that suicidal behavior is a combined outcome of high stressful events and emotion dysregulation together with inadequate behavioral skills for coping with negative emotions and life events. Risk factors for adolescent suicide and intentional self-injury include most importantly family conflict but also conflict with peers, teachers, losses, legal or disciplinary problems (stressful events) combined with high negative emotions and inadequate abilities in emotion regulation. We will analyze the potential mediating effects on suicidal behaviors of decreases in family conflict, increases in parent DBT behavioral skills, reductions in emotion dysregulation and increases in DBT behavioral skills. Preliminary data on cost-effectiveness will also be collected.

描述(申请人提供)：我们研究的长期目标是开发和评估针对自杀高危青少年的有效治疗方法，以减少自杀和自残行为，并改善青少年及其家庭的功能和生活质量。这项研究的主要目的是通过将辩证行为疗法(DBT)与专门为最大化内部效度而选择的个人和团体支持治疗对照条件(I/GST)进行比较，来评估辩证行为疗法对青少年的疗效。研究对象为170名13-17岁的青少年，由于自杀风险高，他们的个性特征处于边缘状态，需要接受治疗。结果目标包括减少自杀行为的频率和严重性，特别是自杀企图，住院或急诊室治疗自杀，增加对治疗的维持和依从性，以及增强多个领域的功能。DBT在成年人中有经验的记录，在符合边缘人格障碍(BPD)标准的个人中减少自杀企图和非自杀性自我伤害的发生率、频率和医疗风险。然而，尽管DBT被广泛用于自杀青少年，特别是那些有BPD特征的困难的人，如情绪调节和冲动控制不良，但DBT在青少年中的随机试验尚未进行。因此，尽管非随机试验表明有效，但如果没有随机试验，我们根本不知道DBT对青少年是否有效。鉴于问题的严重性和高危青少年缺乏替代治疗，解决这一问题很重要。本研究的第二个目的是分析青少年自杀和自伤行为减少的中介因素。DBT基于一个理论模型，即自杀行为是高应激事件和情绪失调以及应对负面情绪和生活事件的行为技能不足的综合结果。青少年自杀和故意自残的危险因素包括最重要的家庭冲突，但也包括与同伴、老师的冲突、损失、法律或纪律问题(应激事件)以及高负面情绪和情绪调节能力不足。我们将分析家庭冲突的减少、父母DBT行为技能的增加、情绪失调的减少和DBT行为技能的增加对自杀行为的潜在中介作用。还将收集有关成本效益的初步数据。