Visual-Motor Development in Infants at High Risk for Autism

自闭症高危婴儿的视觉运动发育

• 批准号: 9088871
• 负责人: Mary Beth Nebel
• 金额: $ 15.24万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-13 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9088871
• 关键词: Advisory Committees; Affect; Age-Months; Autistic Disorder; Behavior; Behavior Therapy; Behavior assessment; Behavioral; Biomedical Engineering; Body part; Brain; Brain imaging; Child; Classification; Code; Collection; Data; Development; Diagnosis; Diagnostics Research; Early Intervention; Exhibits; Functional disorder; Goals; Grant; Image; Individual; Infant; Infant Development; Institutes; Intervention; Knowledge; Laboratories; Language; Lead; Learning; Life; Link; Magnetic Resonance Imaging; Manuals; Measures; Mediating; Mentored Research Scientist Development Award; Mentors; Motor; Movement; Nature; Neurodevelopmental Disorder; Outcome; Parents; Pathway interactions; Pattern; Play; Research; Research Project Grants; Resources; Rest; Risk; Sampling; Scheme; School-Age Population; Science; Scientist; Sensory; Severities; Sleep; Social skills development; Study Subject; Symptoms; System; Testing; Time; Toddler; Training; Visual; Visual Motor Coordinations; Visual system structure; Work; autism spectrum disorder; base; behavior measurement; behavioral outcome; career; clinical care; discounting; experience; eye hand coordination; functional outcomes; high risk; high risk infant; improved; motor deficit; motor impairment; motor learning; neuroimaging; novel; programs; public health relevance; relating to nervous system; response; segregation; skill acquisition; skills; social; statistics; visual feedback; visual motor; visual-motor integration

 DESCRIPTION (provided by applicant): The candidate is a biomedical engineer, committed to developing neuroimaging and behavioral strategies to elucidate developmental mechanisms leading to motor and social deficits in children with Autism Spectrum Disorder (ASD). School-age children with ASD exhibit particular difficulty with tasks that rely on hand-eye coordination and show what appears to be an ASD-specific discounting of visual feedback when learning novel movements. In addition, non-specific perturbations to motor development are observable within the first year of life in infants who later develop ASD and may be among the earliest signs of ASD. Early imitation behavior, which depends critically on visual-motor integration, has been linked with subsequent language and play development in children with ASD and is a common target for intervention. Thus, closer examination of the emergence of motor, and specifically visual-motor, deficits is of critical importance to ASD. We propose to investigate trajectories of visual-motor integration in infants at risk for ASD using both behavioral and brain imaging approaches. To carry out this research, we have begun to develop a novel behavioral measure of visual-motor coordination in infants during a ball-catching task. We will also use resting state functional connectivity MRI (fcMRI) data collected during natural sleep to extract neural measures of visual-motor integration from the same infants. Aims 1 and 2 are focused on extracting these behavioral and neural measures of visual-motor function from AOSI videos and fcMRI data compiled by the Infant Brain Imaging Study (IBIS). We will investigate whether baseline abnormalities and developmental trajectories for these behavioral and neural measures of visual-motor integration differentially predict functional outcomes in affected high-risk infants versus unaffected high-risk infants and controls. Exploratory Aim 3 will then test whether behavioral and neural measures of visual-motor integration can predict individual responses to a parent- mediated intervention using visual-manual activities to target socially engaged imitation. If successful, identifying the neurodevelopmental basis of visual-motor abnormalities in ASD could help stratify ASD into more tractable conditions, which could help identify children in need of early intervention and help determine how to most effectively intervene to help these children fulfill their potential. The candidate has fully engaged a superb advisory team composed of mentors and consultants with complementary skill sets that reflect the interdisciplinary nature of her work. Primary mentor Dr. Stewart Mostofsky, co-mentor Dr. John Pruett and consultants Dr. Rebecca Landa, Joseph Piven, Kelly Botteron and Brian Caffo, are internationally-recognized scientists with a diverse range of expertise in ASD research, clinical care, infant development, developmental imaging science and statistics. Kennedy Krieger Institute has committed to supporting the candidate by providing the necessary laboratory space and financial resources needed to carry out the proposed research. This Mentored Research Scientist Development Award will provide the candidate with a critical training period to acquire knowledge and skills necessary to successfully implement the proposed research project and to develop an independent research career pursuing the interplay of early motor, visual and social skill development in ASD.

 描述（由适用提供）：候选人是一名生物医学工程师，致力于开发神经影像和行为策略，以阐明自闭症谱系障碍儿童（ASD）儿童运动和社会缺陷的发育机制（ASD）。 ASD的学龄儿童在依靠手眼协调的任务中揭示了特别的困难，并在学习新颖的动作时表明了视觉反馈的特定于ASD特定的折扣。此外，在婴儿的第一年，在后来发展ASD并可能是ASD最早的迹象之一的婴儿的第一年，对运动发育的非特异性扰动是可观察的。早期的模仿行为严重取决于视觉运动的整合，它与随后的语言和ASD儿童的发育发展有关，并且是干预的常见目标。仔细研究了电动机的出现，特别是视觉运动对ASD至关重要。我们建议研究使用行为和脑成像方法同时使用ASD的婴儿中视觉运动整合的轨迹。为了进行这项研究，我们已经开始在捕获球的任务期间开发出婴儿在婴儿中的视觉运动协调的新型行为测量。我们还将使用静止状态 在自然睡眠期间收集的功能连通性MRI（FCMRI）数据以从同一婴儿中提取视觉运动整合的神经测量。目标1和2的重点是从婴儿脑成像研究（IBIS）编制的AOSI视频和FCMRI数据中提取这些行为和神经测量值。我们将研究这些行为和神经元测量的基线异常和发育轨迹是否与受影响的高危婴儿相对于未受影响的高危婴儿和对照组的视觉运动整合的测量是否有所不同。然后，探索性目标3将测试视觉运动整合的行为和神经量是否可以通过使用视觉手动活动来预测对父母介导的干预的单个反应，以靶向社会参与的模仿。如果成功的话，请识别ASD视觉运动异常的神经发育基础，可以帮助将ASD分层为更易加的条件，这可以帮助确定需要早期干预的儿童，并帮助确定如何最有效地干预以帮助这些孩子发挥潜力。该候选人已经完全聘请了一个由导师和顾问组成的精湛咨询团队，这些顾问和顾问的完整技能集反映了她工作的跨学科性质。主要导师Stewart Mostofsky博士，同事John Pruett博士和顾问Rebecca Landa，Joseph Piven，Kelly Botteron和Brian Caffo博士是国际认可的科学家，在ASD研究，临床护理，婴儿开发，发展成像科学和统计学方面具有众多专业知识。肯尼迪·克里格研究所（Kennedy Krieger Institute）致力于通过提供拟议研究所需的必要的实验室空间和财务资源来支持候选人。这项受过指导的研究科学家发展奖将为候选人提供一个关键的培训期，以获取成功实施拟议的研究项目所必需的知识和技能，并开发独立的研究职业，以追求ASD早期运动，视觉和社交技能发展的相互作用。