Academic Training in Hematology

描述(由申请人提供)：这是在加州大学洛杉矶分校大卫·格芬医学院重新提交的PHS机构国家服务奖(T32 HL66992)的竞争性续签申请，以帮助博士后研究员为血液学的学术生涯做准备。该奖项于2002年7月设立，在第二年和第三年的血液学/内科肿瘤学培训中支持4个奖学金名额。项目主任为医学博士维克多·马德，副项目主任为医学博士唐纳德·科恩。为了与NHLBI在非恶性血液学方面培训研究员的使命保持一致，我们在我们的计划中做出了重大改变，包括领导力、研究重点以及研究员的选择和资助，用于他们多年的研究培训。值得注意的是，1)任命了一名儿童血液学研究员，他将研究镰状细胞疾病的基因移植；2)取消了白血病的现有研究重点；以及3)重新组织了Trading Grant Leaders，以反映我们对非恶性血液学的关注。自2002年以来，22名研究员在加州大学洛杉矶分校完成了他们的研究员资格，其中15人(68%)积极参与研究，12人(55%)在大学或医学中心担任全职教员或在工业领域担任全职研究职位，3人从事积极的临床研究 方案作为其实践的一部分，包括2名自愿接受大学任命的人。在过去3年(2010-2012年)，8名毕业生中有7名(87.5%)进入了全日制或兼职的大学或行业研究岗位。所有参加该计划的研究员都符合培训补助金资格(TGE)。该学院由31名学术科学家和医生组成，其中89%获得了NIH的拨款，他们分为3个研究重点：造血和干细胞生物学(Don Kohn，MD，主任)、淋巴细胞生物学(John Timmerman，MD，主任)和凝血与血管生物学(Victor Marder，MD，主任)。与互补学科的其他培训计划的互动，特别是远大干细胞研究中心的培训计划、发育血液学的T32培训资助和NCI T32医学肿瘤学的培训资助，强调了可用的资源，以满足我们基础和转化性研究事业的使命。向所有研究员提供核心课程，包括“临床研究课程”，该课程涵盖研究设计和分析、伦理、监管问题、拨款准备和负责任的研究行为等主题。作为STAR计划的一部分，研究员被鼓励获得高级学位，其中2人获得了硕士学位，2人获得了博士学位。对导师的有效性和研究员的成就的正式审查是由指导委员会准备的，该委员会由3名焦点主任、肿瘤科培训补助金的PI(Antoni Ribas，医学博士)和部门奖学金培训计划主任(Arash Naeim，医学博士)组成。每年举行三次研究务虚会，秋季务虚会提出第一年的研究建议并审查第二年的进展报告，春季务虚会提交毕业研究员的最终报告。我们为我们在培训代表不足的少数族裔候选人方面取得的成功感到自豪，自2007年以来，13名候选人中有3名(23%)是西班牙裔或非裔美国人。

DESCRIPTION (provided by applicant): This is a resubmission of a competitive renewal application for a PHS Institutional National Service Award (T32 HL66992) at the David Geffen School of Medicine at UCLA to prepare post-doctoral fellows for an academic career in Hematology. This award was initiated in July, 2002, and supports 4 fellowship slots in years 2 and 3 of Hematology/Medical Oncology training. The Program Director is Victor Marder, MD, and the Associate Program Director is Donald Kohn, MD. In keeping with the NHLBI mission for training fellows in non-malignant hematology, we have made significant changes in our program regarding leadership, research foci, and selection of and funding of fellows for their research years of training. Of note are 1) the appointment of a pediatric hematology fellow who will study gene transplantation in sickle cell disease, 2) the elimination of an existing research focus in Leukemia, and 3) re-organization of Training Grant leadership to reflect our focus on non-malignant hematology. Since 2002, 22 fellows have completed their fellowship at UCLA, 15 of which (68%) are actively involved in research, 12 (55%) as full-time faculty at a University or Medical Center or in a full-time research position in industry, and 3 with active clinical research programs as part of their practice, including 2 who have voluntary university appointments. In the last 3 years (2010-2012), 7 of 8 graduates (87.5%) entered full- or part-time university or industry positions of research. All fellows entering the program are Training Grant Eligible (TGE). The faculty consists of 31 academic scientists and physicians, 89% of whom have NIH grant funding, grouped into 3 research foci, Hematopoiesis and Stem Cell Biology (Don Kohn, MD, Director), Lymphocyte Biology (John Timmerman, MD, Director) and Coagulation and Vascular Biology (Victor Marder, MD, Director). Interaction with other training programs in complementary disciplines, notably those in the Broad Stem Cell Research Center, the T32 Training Grant in Developmental Hematology, and the NCI T32 Training Grant in Medical Oncology, emphasizes the resources available to meet our mission of basic and translational research careers. A core curriculum is offered to all fellows, including a "Clinical Research Course", which covers subjects on research design and analysis, ethics, regulatory issues, grant preparation and responsible conduct of research. Fellows are encouraged to obtain an advanced degree as part of the STAR program, and 2 have obtained the Master's degree and 2 a PhD degree. Formal review of the mentor's effectiveness and the fellow's achievements are prepared by the Steering Committee, made up of the 3 Focus Directors, the PI of the Division Oncology Training Grant (Antoni Ribas, MD, PhD), and the Director of the Division Fellowship Training Program (Arash Naeim, MD, PhD). Three research retreats are held each year, fall retreats at which first year research proposals are proposed and second year progress reports are reviewed, and a spring retreat for final reports of graduating fellows. We are proud of our success in training underrepresented Minority candidates, 3 of 13 (23%) since 2007 being Hispanic or African-American.