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PET-derived 'Dopamine Movies' of Early-Stage Addiction to Cigarette Smoking: A Pilot Study

PET 衍生的早期吸烟成瘾的“多巴胺电影”：一项试点研究

基本信息

批准号：
9142292
负责人：
Evan D Morris
金额：
$ 17.29万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-15 至 2019-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9142292
关键词：
Addictive Behavior Adolescent Alcohol dependence American Award Brain Brain imaging Cigarette Clinical Collaborations Complex Consent Country Cues Data Dependence Development Discipline of Nuclear Medicine Dopamine Event Evolution Female Funding Future Goals Health Hospitals Image Image Analysis Imaging technology International Israel Knowledge Letters Light Location Medical center Methods Military Personnel Motion National Institute of Drug Abuse Neurobiology Neurology Nicotine Dependence Outcome Participant Pattern Pharmaceutical Preparations Pilot Projects Population Positron-Emission Tomography Process Psychiatry Public Health Publishing Raclopride Radioactivity Radiochemistry Recommendation Research Research Personnel Research Subjects Resources Risk Sampling Scanning Scientist Series Services Sex Characteristics Site Smoke Smoker Smoking Soldier Source Speed Staging Target Populations Techniques Technology Testing Universities Withholding Treatment Woman addiction cigarette smoking cohort combat experience field study global health innovation male men movie new technology non-smoker novel strategies reconstruction relating to nervous system response smoking cessation study population success tool volunteer

项目摘要

DESCRIPTION (provided by applicant): Cigarette smoking is a serious global public health issue. Scientists need to better understand the neural substrates of smoking and nicotine dependence in order to guide the development of more effective medications for smoking cessation. The PI and team at Yale have recently developed and deployed a new image analysis technique for producing "dopamine movies" of the brain's response to cigarette smoking. This technique has already yielded exciting findings: we have identified sex differences in the location and speed of the dopamine response to cigarette smoking (Cosgrove, J Neurosci. 2014 Dec 10;34(50):16851-5.). Knowledge Gap: If we could image responses of new smokers to smoking cigarettes during acquisition of addiction we could better understand the relative importance of cues and drug effects in the development of dependence. Unfortunately, the target population for studying developing addiction in most countries would be adolescents, but they are generally not permitted to undergo PET as research subjects Unique study population: Universal military service for men and women in Israel, along with cigarette access in the Israeli army, provides a unique opportunity to researchers to study the onset of smoking addiction. Our long term goal is to study this unique cohort with PET and dopamine movies to better understand the acquisition of smoking addiction. First, we must accomplish our short term goal: to validate the use of our technology at a PET site in Israel with access to the study population. International Collaboration: This project would be a collaboration between Yale imaging innovators and and PET scientists and other researchers at Hadassah /Hebrew University to take advantage of the unique study population in Israel. The collaboration's immediate goal would be to establish the (NIDA-supported) imaging technology necessary to execute a large study of early-stage smokers at the research site in Israel. Re-analyses in various modes of the recently-published Yale data will help to validate and explain the results of the pilot study to be obtained in Israel. The project is intended to disseminate NIDA-funded technology through partnership with a highly regarded foreign collaborator in order to seize the opportunity to study smoking addiction in early-smokers thanks to unique circumstances in Israel.

描述（由申请人提供）：吸烟是一个严重的全球公共卫生问题。科学家需要更好地了解吸烟和尼古丁依赖的神经基础，以指导开发更有效的戒烟药物。耶鲁大学的 PI 和团队最近开发并部署了一种新的图像分析技术，用于制作大脑对吸烟反应的“多巴胺电影”。这项技术已经取得了令人兴奋的发现：我们已经确定了多巴胺对吸烟反应的位置和速度存在性别差异（Cosgrove, J Neurosci. 2014 Dec 10;34(50):16851-5.）。知识差距：如果我们能够想象新吸烟者在成瘾过程中对吸烟的反应，我们就可以更好地理解线索和药物作用在依赖性发展中的相对重要性。不幸的是，大多数国家研究烟瘾形成的目标人群是青少年，但他们通常不被允许作为研究对象接受 PET 治疗。独特的研究人群：以色列男女普遍服兵役，加上以色列军队允许吸烟，为研究人员研究烟瘾的发病提供了独特的机会。我们的长期目标是通过 PET 和多巴胺电影来研究这个独特的群体，以更好地了解烟瘾的形成。首先，我们必须实现我们的短期目标：在以色列的 PET 站点接触研究人群，验证我们的技术的使用情况。国际合作：该项目将是耶鲁大学成像创新者与哈达萨/希伯来大学的 PET 科学家和其他研究人员之间的合作，以利用以色列独特的研究人群。此次合作的近期目标是建立（NIDA 支持的）成像技术，这是在以色列研究地点对早期吸烟者进行大型研究所必需的。对最近发布的耶鲁大学数据进行各种模式的重新分析将有助于验证和解释将在以色列获得的试点研究的结果。该项目旨在通过与一位备受推崇的外国合作者合作传播 NIDA 资助的技术，以便抓住以色列独特情况研究早期吸烟者烟瘾的机会。