New Mechanisms in Axon Regeneration
New Mechanisms in Axon Regeneration
批准号:
9125882
负责人:
MARC HAMMARLUND
金额:
$36.42万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2015
资助国家:
美国
项目状态:
已结题
起止时间:
2015-08-15 至 2020-07-31
关键词:
AffectAnimal ModelBiologicalBiological ProcessBuffersCaenorhabditis elegansCalciumCandidate Disease GeneCell DeathCell physiologyCellsCellular biologyClustered Regularly Interspaced Short Palindromic RepeatsDataDrug DesignEmployee StrikesGenerationsGenesGeneticGenetic TranscriptionGenome engineeringGoalsGrantHealthIndividualInjuryKnowledgeLifeLinkMAPK1 geneMediatingMitochondriaMolecularMusNatural regenerationNervous system structureNeuronal InjuryNeuronsOutcomeOutputPathway interactionsPoly Adenosine Diphosphate RibosePost-Translational Protein ProcessingProcessPropertyProteinsPublic HealthRecovery of FunctionRegulationReporterResearchSignal TransductionSiteTissuesTranscriptional RegulationWallerian DegenerationWorkaxon injuryaxon regenerationaxonal degenerationbaseflyfunctional lossfunctional restorationgenetic analysisin vivoin vivo imaginginhibitor/antagonistinjuredinsightnerve injurynervous system disorderneuron lossnovelnovel strategiespromoterregenerativeresearch studyresponseresponse to injurytraffickingtranscription factor
中文摘要
英文摘要
DESCRIPTION (provided by applicant): Axon regeneration is a fundamental and conserved property of nervous systems. But although axon regeneration can restore function after nerve injury, regeneration often fails. Thus, a key question in the field is to discover what determines the regenerative capacity of injured neurons. This proposal investigates new mechanisms that function in the injured neuron and that help determine whether or not regeneration occurs. The long-term goal is to gain a comprehensive understanding of the cellular functions that link neuronal injury to successful regeneration. The specific goal of this project is to analyze three novel and interrelated mechanisms that regulate axon regeneration at the genetic, cellular, and molecular level. The project uses a combination of in vivo approaches that culminate in analysis of the injury response in individual neurons. The central hypothesis is that the three novel mechanisms act in a pathway that regulates axon regeneration and the neuronal injury response. However, each Aim is independent and will result in fundamental discoveries about the cell biology of axon regeneration even if the individual mechanisms operate in parallel rather than in a linear pathway. Each Aim is supported by extensive preliminary data, as well as by novel biological concepts and experimental approaches. Completion of these Aims will describe fundamental cellular mechanisms that mediate axon regeneration.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Discovery and analysis of the C. elegans neuronal gene expression network (CENGEN)
-
批准号:10226108
-
项目类别:
-
资助金额:$124.21万
-
财政年份:2017
-
负责人:MARC HAMMARLUND
-
依托单位:
Discovery and analysis of the C. elegans neuronal gene expression network (CENGEN)
-
批准号:9750834
-
项目类别:
-
资助金额:$124.21万
-
财政年份:2017
-
负责人:MARC HAMMARLUND
-
依托单位:
Discovery and analysis of the C. elegans neuronal gene expression network (CENGEN)
-
批准号:9473492
-
项目类别:
-
资助金额:$111.28万
-
财政年份:2017
-
负责人:MARC HAMMARLUND
-
依托单位:
Discovery and analysis of the C. elegans neuronal gene expression network (CeNGEN)
-
批准号:10608790
-
项目类别:
-
资助金额:$135.36万
-
财政年份:2017
-
负责人:MARC HAMMARLUND
-
依托单位:
Evaluation of Novel Axon Regeneration Targets for Spinal Cord injury Therapy
-
批准号:9196896
-
项目类别:
-
资助金额:$38.27万
-
财政年份:2016
-
负责人:MARC HAMMARLUND
-
依托单位:
Mechanisms and Regulation of Neuronal Aging
-
批准号:9340824
-
项目类别:
-
资助金额:$60.63万
-
财政年份:2016
-
负责人:MARC HAMMARLUND
-
依托单位:
New mechanisms in axon regeneration
-
批准号:10211489
-
项目类别:
-
资助金额:$41.33万
-
财政年份:2015
-
负责人:MARC HAMMARLUND
-
依托单位:
New mechanisms in axon regeneration
-
批准号:10475481
-
项目类别:
-
资助金额:$7.77万
-
财政年份:2015
-
负责人:MARC HAMMARLUND
-
依托单位:
New mechanisms in axon regeneration
-
批准号:10372206
-
项目类别:
-
资助金额:$41.33万
-
财政年份:2015
-
负责人:MARC HAMMARLUND
-
依托单位:
New mechanisms in axon regeneration
-
批准号:10613452
-
项目类别:
-
资助金额:$41.33万
-
财政年份:2015
-
负责人:MARC HAMMARLUND
-
依托单位:
A novel mechanism that inhibits axon regeneration
-
批准号:8809015
-
项目类别:
-
资助金额:$41.63万
-
财政年份:2014
-
负责人:MARC HAMMARLUND
-
依托单位:
Identification of transcriptional targets of the DLK-1 axon regeneration pathway
-
批准号:8636246
-
项目类别:
-
资助金额:$25.75万
-
财政年份:2013
-
负责人:MARC HAMMARLUND
-
依托单位:
Identification of transcriptional targets of the DLK-1 axon regeneration pathway
-
批准号:8722641
-
项目类别:
-
资助金额:$20.06万
-
财政年份:2013
-
负责人:MARC HAMMARLUND
-
依托单位:
Horseman, pass by: finding post-developmental functions of essential genes
-
批准号:8089408
-
项目类别:
-
资助金额:$32.44万
-
财政年份:2009
-
负责人:MARC HAMMARLUND
-
依托单位:
Horseman, pass by: finding post-developmental functions of essential genes
-
批准号:8296525
-
项目类别:
-
资助金额:$32.44万
-
财政年份:2009
-
负责人:MARC HAMMARLUND
-
依托单位:
Horseman, pass by: finding post-developmental functions of essential genes
-
批准号:7713378
-
项目类别:
-
资助金额:$33.1万
-
财政年份:2009
-
负责人:MARC HAMMARLUND
-
依托单位:
海外基金