New mechanisms in axon regeneration

轴突再生的新机制

• 批准号: 10613452
• 负责人: MARC HAMMARLUND
• 金额: $ 41.33万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-15 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10613452
• 关键词: Address; Affect; Aging; Axon; Behavioral Assay; Biological; Caenorhabditis elegans; Cell physiology; Cells; Cellular biology; Complex; Data; Defect; Dendrites; Development; Developmental Process; Disease; Electron Microscopy; Failure; Functional Regeneration; Genetic; Genomics; Goals; Growth; Human; Injury; Knowledge; Link; Location; MAPK8 gene; Maintenance; Mediating; Mitochondria; Molecular; Natural regeneration; Nervous System; Nervous System Trauma; Neuronal Injury; Neurons; Neurosciences; Outcome; Output; Pathway interactions; Process; Property; Public Health; Recording of previous events; Recovery of Function; Regulation; Research; Signal Transduction; Site; Structure; Synapses; System; Time; Work; axon injury; axon regeneration; cell assembly; cell growth regulation; experimental study; functional loss; functional restoration; genetic approach; healing; improved; in vivo; in vivo regeneration; insight; model organism; nerve injury; nervous system development; notch protein; novel; novel strategies; postsynaptic; presynaptic; prevent; real-time images; reconstruction; restoration; synaptic function; synaptogenesis; targeted treatment; trafficking; transmission process

PROJECT SUMMARY Axon regeneration is a fundamental and conserved property of nervous systems. But axon regeneration often fails to restore function after nerve injury. Thus, a key question in the field is to discover what determines the capacity of injured neurons to rebuild functional circuits. This proposal investigates new mechanisms that function in the injured neuron and that help determine whether or not effective regeneration occurs. The long-term goal is to gain a comprehensive understanding of the cellular functions that link neuronal injury to successful functional regeneration. The specific goal of this project is to analyze the process of synapse regeneration. The project uses a combination of in vivo approaches aimed at understanding how synapse regeneration works, why it fails to restore normal function, and how it can be improved. Completion of these Aims will describe fundamental cellular mechanisms that mediate functional axon regeneration after nerve injury.

项目摘要 轴突再生是神经系统的基本和保守特性。但是轴突 神经损伤后的再生通常不能恢复功能。因此，该领域的关键问题是 来发现是什么决定了受损神经元重建功能回路的能力。这 该提案研究了在受伤神经元中发挥作用并有助于治疗的新机制 确定是否发生有效再生。长期目标是获得 全面了解细胞功能，将神经元损伤与成功的 功能再生这个项目的具体目标是分析突触的过程 再生该项目采用了一种结合体内方法，旨在了解 突触再生是如何工作的，为什么它不能恢复正常功能，以及它是如何 提高完成这些目标将描述基本的细胞机制， 介导神经损伤后的功能性轴突再生。