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中文摘要
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描述(由申请人提供):该项目支持由国际内毒素和天然免疫学会(IEIIS)联合举办的第47届白细胞生物学学会年会,该年会将于2014年10月23-26日在犹他州盐湖城喜来登酒店举行。这次SLB和IEIIS联席会议将在2010年成功举行的SLB/IEIIS联席会议的基础上再接再厉。2014年联席会议的中心主题将是发展先天免疫。该项目经过精心设计,旨在最大限度地促进两个社会之间的科学互动,以促进合作。我们一直在努力创建一个项目,将全体会议、小型研讨会和海报会议与明确定义的网络会议平衡起来。为了方便对话和互动,并让与会者留在会议地点,在几次休息时间将提供食物和饮料。已计划举行专门的会议,讨论研究项目的翻译方面,其中包括一次“针对免疫治疗疾病”的会议。专业发展讲习班被纳入该方案,其中包括一次赠款编写讲习班、一次关于网络技能的会议以及一次妇女与多样性讲习班。为了最大限度地促进这一重要领域的科学交流和初级科学家的培训,本提案请求美国国立卫生研究院为2014年SLB年度科学会议“先天性免疫的发展”提供支持,以允许与会者通过旅行奖励和分担费用获得更多机会。具体目标1.提供一个探讨天然免疫如何发展的新概念的合议性论坛。具体会议将讨论(1)适当使用动物模型来了解人类疾病,(2)生物工程和微流体,(3)骨髓细胞前体,(4)免疫系统发育,(5)免疫个体发育和(6)疫苗开发。这些主题与我们对包括传染病、癌症和心血管疾病在内的严重疾病以及由自身免疫疾病引起的无菌炎症的理解密切相关。该方案将邀请该领域的老牌领导人和后起之秀发表演讲,并由从世界各地实验室提交的摘要中挑选出来的初级调查人员/实习生进行口头和/或海报介绍。这次会议的目标是来自学术、政府、临床和工业实验室的大约350-450名与会者。具体目标2.通过海报和口头会议的密切互动,为青年研究人员和受训学生提供与知名科学家密切互动的机会。将举办专门的职业发展讲习班以及关于赠款编写和出版的培训课程,以促进有抱负的学生和初级调查人员的培训和发展。旅行奖励将根据科学功绩颁发给选定的参与者。本次会议参与人数较少,海报会议时间充裕,为初级调查人员与先天免疫发展领域的领先科学家进行严谨讨论创造了一个合议的学习环境。具体目标3.通过促进妇女、少数民族和残疾科学家的参与,促进白细胞生物学和先天免疫领域的多样性。将举办一个专门论坛,重点讨论妇女和少数群体科学家面临的障碍,并将举办联网和职业发展讲习班,以解决职业发展的障碍和机会。
英文摘要
DESCRIPTION (provided by applicant): This project supports the 47th Annual Meeting of the Society for Leukocyte Biology, jointly with the International Endotoxin and Innate Immunity Society (IEIIS), to be held at the Salt Lake City Sheraton, Salt Lake City, Utah during October 23-26, 2014. This joint meeting of SLB and IEIIS will build upon the highly successful joint SLB/IEIIS meeting held in 2010. The central theme of the 2014 joint meeting will be the development of innate immunity. The program has been carefully designed to maximize scientific interactions between the two societies to foster collaborations. We have worked diligently to create a program that balances plenary sessions, mini-symposia and poster sessions with clearly defined networking sessions. To facilitate dialog and interaction, and keep attendees at the meeting venue, food and beverages will be provided at several of the breaks. Specific sessions have been planned to discuss the translational aspects of research projects, including a session "Targeting Immunity to Treat Disease" among others. Professional development workshops are incorporated into the program which include a grant writing workshop, a session on networking skills, and a Women and Diversity workshop. To best facilitate scientific exchange and training of junior scientists in this important area, this propoal requests NIH support for the 2014 SLB annual scientific conference entitled "Development of Innate Immunity" to allow greater access for participants via travel awards and shared costs. Specific Aim 1. To provide a collegial forum exploring new concepts on how innate immunity develops. Specific sessions will address (1) Appropriate use of animal models to understand human disease, (2) Bioengineering and microfluidics, (3) Myeloid cell precursors, (4) immune phylogeny, (5) immune ontogeny and (6) vaccine development. These topics bear critical relevance to our understanding of severe diseases including infectious diseases, cancer, and cardiovascular disease as well as sterile inflammation resulting from autoimmune diseases. The program will feature invited presentations from established leaders and rising stars in the field, as well as oral and/or poster presentations by junior investigators/ trainees selected from among the abstracts submitted by laboratories worldwide. The meeting will target approximately 350-450 participants from academic, governmental, clinical and industrial laboratories. Specific Aim 2. To provide an opportunity for young investigators and student trainees to interact closely with established scientists, through close interaction in both poster and oral sessions. A dedicated career development workshop as well as a training session on grant writing and publication will be held to foster the training and development of aspiring students and junior investigators. Travel awards will be administered to selected participants based on scientific merit. The smaller number of participants and ample time for the poster sessions at this meeting creates a collegial learning environment for junior investigators to engage in rigorous discussion with the leading scientists in the area of innate immunity development. Specific Aim 3. To promote diversity in the field of leukocyte biology and innate immunity by fostering the participation of women, minority, and disabled scientists. A specific forum focusing on obstacles facing women and minority scientists will be held and networking and professional career development workshops will be organized to address obstacles and opportunities for career development.
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Modulation of innate immune exhaustion during sepsis
Novel mechanisms for the generation of resolving monocytes
Altered innate leukocyte programming dynamics in sepsis
Altered innate leukocyte programming dynamics in sepsis
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