A NHP model for vaginal Zika Virus transmission
A NHP model for vaginal Zika Virus transmission
批准号:
9255998
负责人:
CHRISTOPHER James MILLER
金额:
$31.22万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-09-01 至 2017-08-31
关键词:
AdultAnimal ModelAnimalsAntibody ResponseAntiviral AgentsArthralgiaBiological AssayBiologyBrainBrazilCaribbean regionCenters for Disease Control and Prevention (U.S.)Central AmericaCoitusConjunctivitisCountryCulicidaeDevelopmentDisease OutbreaksDoseEnzyme-Linked Immunosorbent AssayExanthemaExposure toFemaleFeverFlaviviridaeFlavivirusFlow CytometryFrequenciesGenital systemGoalsHealthHourHumanImmuneImmune responseImmunologyInfantInfectionIrrigationLesionMacacaMacaca mulattaMessenger RNAMicrocephalyModelingMusNatureNeurologicPathogenesisPeripheral Blood Mononuclear CellPlasmaPregnancyProteinsPublishingReportingResearchRouteSamplingSeminal fluidSentinelSexual TransmissionSouth AmericaStaining methodStainsSymptomsSyndromeT cell responseTestingTimeTinnitusUgandaUrineVaccinesVaginaVirusVirus DiseasesWomanWorld Health OrganizationZika Virusadaptive immunityantiviral immunitycervicovaginalcytokineforesthearing impairmentlissencephalymalemennonhuman primatepandemic diseasepreventpublic health emergencyreproductive tracttransmission processviral transmissionvirology
中文摘要
寨卡病毒(黄病毒科,黄病毒)是一种新出现的蚊媒病毒
英文摘要
Zika virus (ZIKV) (Flaviviridae, flavivirus), an emerging mosquito-borne virus, was first detected in Brazil in
2015 and has since spread to at least 38 countries in South America, Central America and Caribbean. The
World Health Organization declared the ZIKV pandemic a public health emergency on February 1, 2016. In
approximately 20% of infected humans, ZIKV causes a febrile illness that can include rash, arthralgia and
conjunctivitis. In addition, ZIKV has been associated with the development of microcephaly and
lissencephaly and ocular lesions in infants born to women who acquired ZIKV infection during early
pregnancy. In adults, ZIKV has also been associated with Guillan-Barré syndrome and other neurological
complications including hearing loss and tinnitus. Very little research has been done with ZIKV and our
understanding of the virology, immunology and pathogenesis of ZIKV disease in humans is very limited.
There are no established animal models, although a few studies have been imitated in the past few months.
(NHP), and until February 2016, no NHP had been inoculated with contemporary pandemic ZIKV isolates.
Although ZIKV is a mosquito-transmitted virus, reports of women becoming infected through sexual
intercourse with ZIKV infected men have come from countries with no evidence of mosquito transmission. In
fact, during February 6–22, 2016, health officials from several states reported two confirmed and four
probable cases of ZIKV sexual transmission to CDC. In all cases, condomless vaginal intercourse occurred
when the male partner was symptomatic or shortly after symptoms resolved. In addition, there are earlier
reports suggesting ZIKV sexual transmission prior to the current outbreak, ZIKV virus has been found in
semen and a recent report suggested ZIKV persists in semen for more than 60 days after onset of
symptoms. Despite these observations the frequency and efficiency of sexual ZIKV transmission is unclear.
To better understand the potential for sexual transmission of ZIKV and to test whether vaccines can prevent
ZIKV transmission by this route an animal model is needed. The goal of this R21 is to develop a NHP model
of vaginal ZIKV transmission. We will conduct initial studies to determine the efficiency of vaginal ZIKV
transmission and characterize the virology of the infection. Further, we will characterize and compare innate
and adaptive immune responses to ZIKV in the genital tract and systemic compartment.
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海外基金