CYCORE: Cyberinfrastructure for Cancer Comparative Effectiveness Research

描述(由申请人提供)：我们建议在国家癌症研究所的支持下，继续并显著扩展我们于2010年开始的研究，以开发一种系统，改进癌症临床试验中患者报告的以及客观测量的患者数据的捕获。该系统名为CyCORE(用于比较有效性研究的网络基础设施)，是一个强大的基于软件的原型，用于用户友好的网络基础设施(CI)，支持获取、存储、可视化、分析和共享对癌症相关比较有效性研究(CER)重要的数据。我们最初的项目是为了解决如何收集参加癌症临床试验的患者的数据的问题，这将提高癌症研究人员收集患者报告的数据的能力，这些数据包括症状、生活质量、表现状态和生理参数，这些数据表明参与者的治疗效果如何。我们已经开发了一个初步的、非常成功的CyCORE原型，并在几个用例中对其进行了测试，现在已经拥有了一个规模较小但非常热情的用户社区。我们在此提出的建议既基于我们对系统可伸缩性和可扩展性的关键需求的评估，也基于用户关于他们认为在CyCORE中有用的内容以及他们希望在后续版本中看到的功能的输入。因此，我们努力将CyCORE定位为独特的，以支持人们对与癌症相关的CER迅速增长的兴趣。我们对CyCORE的愿景是在各种研究环境中支持更多的研究人员社区。在该项目中，我们重点关注以下目标：目标1：提高可扩展性和性能：利用面向服务的架构、虚拟化和云计算的新兴趋势来扩展我们的基础设施，以适应现有和新兴的传感器、处理、分析和报告工具。目标2：扩展新传感器的能力，解决容错和自我修复问题。开发和测试从新传感器获取的数据，同时提高系统的可靠性。目的3：为CyCORE介绍一个新的癌症控制用例目标4：采用支持检测和分析癌症CER中重要结果的新算法。为算法定义和执行提供通用基础设施，并实现试点试验所需的一些算法(例如，脱水、性能状态、运动和戒烟)。目标5：提高CyCORE的安全、隐私和数据共享能力-优化CyCORE处理与数据安全、匿名化和机密性相关的问题的方式，以促进数据共享。与外部系统集成，将数据摄取到CyCORE中，还可以将数据导出，以便与其他研究人员共享。目标6：制定和实施可持续发展模式--为中心制定可持续发展模式，以确保今后对方案编制、项目和外联工作人员的支持。目标7：扩大和丰富CyCORE用户社区。扩大、支持和培育CyCORE用户社区。

DESCRIPTION (provided by applicant): We propose to continue and significantly extend the research we began in 2010, with support from the National Cancer Institute, to develop a system that improves the capture of patient-reported as well as objectively measured data from patients in cancer clinical trials. The system, CYCORE (CYberinfrastructure for COmparative effectiveness REsearch), is a robust software-based prototype for a user-friendly, cyberinfrastructure (CI) that supports the acquisition, storage, visualization, analysis, and sharing of data important for cancer-related comparative effectiveness research (CER). Our initial project began with the intent to solve the problem of how to collect data on patients enrolled in cancer clinical trials that would improve the ability of cancer researchers to gather patient-reported data on such things as symptoms, quality of life, performance status and physiological parameters that signal how well participants are doing with their treatment. We have developed an initial, highly successful prototype of CYCORE, tested it in several use- cases, and now have a small but highly enthusiastic community of users. What we propose herein is based both on our assessment of critical needs for scalability and extensibility of the system as well as on user input about what they find useful in CYCORE and what features they would like to see in subsequent versions. Hence, we endeavor to position CYCORE uniquely to support a rapidly growing interest in cancer-related CER. Our vision for CYCORE is to support an expanded community of researchers in a variety of research settings. In this project, we focus on the following Aims: Aim 1: Improve scalability and performance: Exploit the emerging trends in service-oriented architectures, virtualization, and cloud computing to scale our infrastructure to accommodate both existing and emerging sensors, processing, analysis and reporting tools. Aim 2: Expand capability for new sensors and address fault tolerance and self-healing. Develop and test the acquisition of data from new sensors, while increasing the system's reliability. Aim 3: Introduce a new cancer control use case for CYCORE Aim 4: Incorporate new algorithms that support the detection and analysis of outcomes important in cancer CER. Provide a generic infrastructure for algorithm definition and execution and implement some of the algorithms needed for the pilot trials (e.g., dehydration, performance status, movement, and smoking cessation). Aim 5: Improve security, privacy and data sharing capabilities of CYCORE - optimize how CYCORE handles issues related to data security, anonymization, and confidentiality in order to facilitate data sharing. Integrate with external systems to ingest data into CYCORE and also to export data for sharing with other researchers. Aim 6: Develop and Implement a model for sustainability - develop a sustainability model for CYCORE to ensure support for programming, project and outreach staff in the future. Aim 7: Expand and enrich the community of CYCORE users. Expand, support and nurture the community of CYCORE users.