Primary Infection Resource Consortium (Pirc)

原发感染资源联盟 (Pirc)

• 批准号: 9108834
• 负责人: SUSAN JANET LITTLE
• 金额: $ 144.35万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-20 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9108834
• 关键词: Acute; Address; Adherence; Adult; Advisory Committees; Archives; Area; Behavioral; Biocompatible Materials; Biological; Biological Assay; Chronic; Clinical; Collaborations; Communities; Computer software; Concept Review; Data; Data Collection; Data Storage and Retrieval; Disclosure; Emerging Technologies; Enrollment; Ensure; Epidemic; Epidemiology; Event; Feedback; Future; Genetic; Genotype; HIV; HIV Infections; HIV-infected adolescents; Individual; Infection; Information Technology; International; Investigation; Laboratories; Leadership; Link; Liquid substance; Lymphocyte; Methodology; Methods; Modeling; Monitor; Monoclonal Antibody R24; Natural History; Nucleic Acid Amplification Tests; Online Systems; Oral; Paper; Participant; Peripheral Blood Mononuclear Cell; Persons; Pharmaceutical Preparations; Phylogenetic Analysis; Plasma; Prevention; Primary Infection; Principal Investigator; Procedures; Process; Recruitment Activity; Refractory; Research; Research Design; Research Infrastructure; Research Personnel; Research Proposals; Resistance; Resource Sharing; Resources; Risk; Sampling; Services; Sex Behavior; Sexual Partners; Shipping; Ships; Software Tools; Specimen; Staging; Statistical Models; Strategic Planning; Swab; System; Testing; Time; Viral Load result; Vision; analytical method; cohort; cost efficient; data access; data management; demographics; design; drug of abuse; flexibility; genital secretion; human subject; network models; novel; open source; point of care; programs; prospective; quality assurance; rectal; sample collection; screening; statistics; superinfection; transmission process; web site

DESCRIPTION (provided by applicant): The San Diego Primary Infection Resource Consortium (PIRC) R24 application represents an opportunity to sustain more than 16 years of remarkably productive collaborative research related to the identification and recruitment of persons with acute and early HIV (AEH) infection from the San Diego community. Using novel and evolving methods to recruit persons with AEH, we have established extensive infrastructure and community support to test 3,600 individuals annually using dual point-of-care HIV rapid test (RT) screening, paired with HIV nucleic acid testing (NAT) in all RT negative persons. The projected HIV screening program will ensure the identification and recruitment of 45 AEH, 40 chronic HIV (C-HIV), 40 sexual partners (SP) of participants with AEH (both transmitting and non-transmitting) and 120 repeatedly-exposed, HIV uninfected (EU-HIV) individuals each year. From these participants, vve propose to collect, process, cryostore, and make available a variety of biological specimens (depending on stage of HIV infection), including blood plasma, peripheral blood mononuclear cells (PBMC), genital secretions, rectal swabs, and oral fluid. We also record extensive demographic, behavioral, and risk data that are linked to participants and their stored specimens. The PIRC proposes to offer access to both archived and prospective resources using a multi- institutional review of concept sheet research proposals submitted by eligible consortium investigators. In order to provide access to richly annotated data and specimens and to enable prospective basic, translational, epidemiologic, and modeling research, the PIRC will address the following Specific Aims: 1) Program oversight and research access to PIRC; 2) Identify, enroll, and retain a cohort representative of the San Diego HlV epidemic and suitable for accurate inference of transmission dynamics; 3) Collect clinical and behavioral information, and biological samples from piRC participants; 4) Provide integrated, flexible and accessible data management and information technology guidance and support; and 5) Provide statistical and network modeling expertise. The PIRC will provide a sophisticated online data storage and retrieval system that will facilitate concept sheet submission and data access for consortium investigators. RELEVANCE: The San Diego Primary Infection Resource Consortium (PIRC) will provide extensive clinical and behavioral data, biological materials, open source software tools, and services that are of high quality and cost-efficient. The breadth of the collected data will represent a significant opportunity for consortium investigators to evaluate pressing issues related to HIV transmission, prevention, resistance, superinfection, and eradication.

描述（由申请人提供）：圣地亚哥原发性感染资源联盟（PIRC） R24申请代表了一个机会，可以维持超过16年的与圣地亚哥社区急性和早期HIV （AEH）感染患者的识别和招募相关的卓有成效的合作研究。我们采用新颖和不断发展的方法招募AEH患者，建立了广泛的基础设施和社区支持，每年对3600人进行双重护理点艾滋病毒快速检测（RT）筛查，并对所有RT阴性的人进行艾滋病毒核酸检测（NAT）。预计的HIV筛查计划将确保每年识别和招募45名AEH， 40名慢性HIV (C-HIV)， 40名AEH参与者的性伴侣（SP）（包括传播性和非传播性）和120名反复暴露的HIV未感染者（EU-HIV）。从这些参与者中，我们建议收集、处理、冷冻并提供各种生物标本（取决于HIV感染的阶段），包括血浆、外周血单个核细胞（PBMC）、生殖器分泌物、直肠拭子和口腔液。我们还记录了与参与者及其存储标本相关的广泛的人口统计、行为和风险数据。PIRC建议通过对符合条件的联合研究人员提交的概念表研究建议的多机构审查，提供对存档和潜在资源的访问。为了提供对丰富的注释数据和标本的访问，并使未来的基础、转化、流行病学和模型研究成为可能，PIRC将解决以下具体目标：1)项目监督和对PIRC的研究访问；2)确定、登记并保留一个具有圣地亚哥HlV流行代表性并适合准确推断传播动态的队列；3)收集piRC参与者的临床和行为信息，以及生物样本；4)提供集成、灵活、可及的数据管理和信息技术指导与支持；5)提供统计和网络建模专业知识。PIRC将提供一个复杂的在线数据存储和检索系统，该系统将为联合调查人员提供概念表提交和数据访问便利。