Regulation of Airway Protective Behaviors
Regulation of Airway Protective Behaviors
批准号:
9041011
负责人:
Teresa G Pitts
金额:
$24.37万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-02-23 至 2018-03-31
关键词:
AcuteAlzheimer&aposs DiseaseBehaviorBehavioralCharacteristicsCoughingDataDeglutitionDeglutition DisordersDiseaseDisease modelEventExcitatory Amino Acid AntagonistsFeedbackFoodGoalsKynurenic AcidLarynxLiquid substanceMedialMicroinjectionsModelingMovementNeuronsOralOral cavityParkinson DiseasePathway interactionsPatternPeripheralPharyngeal structurePhaseProcessProductionRegulationReticular FormationRoleSalivaSensorySeriesSpecificityStimulusTestingTracheaTrainingbehavioral responsemulti-electrode arraysnetwork modelspreventprotective behaviorsensory feedbacktherapeutic target
中文摘要
这个项目的长期目标是确定气管和咽感觉反馈的作用
英文摘要
The long-term goal of this project is to determine the role of tracheal and pharyngeal sensory feedback in
the regulation of cough and swallow. Our central hypothesis is that an aspiration event produces a series of
coughs and swallows which are expressed in various behavioral interaction patterns, and that there are
decipherable rules that regulate the various patterns of expression. Cough and swallow are airway
protective behaviors. The pharyngeal phase of swallow prevents aspiration of oral material (saliva, food and
liquid), by epiglottal movement, laryngeal adduction, and clearing the mouth and pharynx. Cough is an
aspiration-response behavior that clears material from the airway. Coordination of these behaviors is vital to
protect the airway from further aspiration-promoting events, such as a swallow occurring during the
inspiratory phase of cough. The peripheral inputs, operational characteristics, and primary strategies that
coordinate cough and swallow are unknown. This lack of information impedes understanding of the deficits
in airway protection, with co-occurrence of dystussia and dysphagia, which occurs with diseases such as
Parkinson's disease and Alzheimer's disease. The Specific Aims of the project are: 1) Develop a predictive
computational distributed network model of the central influence of tracheal sensory pathways on the
expression of cough and swallow; and 2) Identify the role of neurons in the reticular formation in processing
tracheal and pharyngeal afferent feedback on cough and swallow. Our preliminary data demonstrates a
modulatory effect of sensory feedback of the production of cough and swallow. Stimulation of tracheal
afferents by an aspiration stimulus increases the magnitude of swallows, providing evidence of airway
feedback-induced increased pharyngeal clearance. In aim 2, we will: 1) record from neurons in the reticular
formation using a multi-electrode array to obtain multiple-spike train data during: a) the selective stimulation
of the trachea or pharynx to elicit cough or swallow; 2) test an acute model of dystussia and dysphagia
induced by microinjection of the endogenous excitatory amino acid antagonist, kynurenic acid, into the
medial reticular formation.
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Regulation of swallow and the effects of high cervical spinal cord injury
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批准号:10063070
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项目类别:
-
资助金额:$33.69万
-
财政年份:2018
-
负责人:Teresa G Pitts
-
依托单位:
Regulation of swallow and the effects of high cervical spinal cord injury
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批准号:10322117
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项目类别:
-
资助金额:$33.69万
-
财政年份:2018
-
负责人:Teresa G Pitts
-
依托单位:
Regulation of swallow and the effects of high cervical spinal cord injury
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批准号:10533348
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项目类别:
-
资助金额:$33.69万
-
财政年份:2018
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负责人:Teresa G Pitts
-
依托单位:
Regulation of Airway Protective Behaviors
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批准号:9266814
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项目类别:
-
资助金额:$23.82万
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财政年份:2013
-
负责人:Teresa G Pitts
-
依托单位:
Regulation of Airway Protective Behaviors
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批准号:8443277
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项目类别:
-
资助金额:$13.34万
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财政年份:2013
-
负责人:Teresa G Pitts
-
依托单位:
Regulation of Airway Protective Behaviors
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批准号:8626251
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项目类别:
-
资助金额:$13.34万
-
财政年份:2013
-
负责人:Teresa G Pitts
-
依托单位: