Core B-Specimen and Reagent Core

核心B的主要意义在于，它将为接收、跟踪、存储、 和分发所有三个项目产生的有价值的生物标本，除了提供 项目的标准化研究试剂。这将使用既定的标准来完成 我们正在进行的多项目计划的运作程序，由条例草案拨款资助 和梅琳达·盖茨基金会。这一战略加强了项目间的数据质量，并提供 对质量保证的高度问责。此外，核心B将存档两个生物 用于被动免疫的标本和测试品，如免疫原和单抗。这些将是 根据三个项目的需要使用，并将根据要求与更大的研究社区共享 由其他调查人员所为。这三个项目将优先接收标本和测试物品 来实现他们的特定目标。首席调查员和项目负责人将确定 在定期安排的电话会议期间额外使用样本和测试物品，如 在紧急需要的情况下，将通过临时电话会议作出决定。同一支队伍 将特别为有限的标本或测试物品确定外部请求的优先顺序。如果 所要求的材料不是限量的，形式上是可以接受的。核心B还将与核心A密切合作 在那里，数据将被存档，以确保可以很容易地追溯到标本和测试物品。这个 核心B的目标将通过两个具体目标来实现。目标1：提供免疫和免疫的标本 挑战恒河猴。目的2：为该项目提供抗体和蛋白质试剂。

The principal significance of Core B is that it will provide a centralized source for the receipt, tracking, storage, and distribution of valuable biological specimens generated by all three projects in addition to providing standardized research reagents to the projects. This will be accomplished using established standard operating procedures that are in place from our ongoing multi-project programs funded by grants from The Bill and Melinda Gates Foundation. This strategy strengthens the quality of data across the projects and provides a high-degree of accountability for quality assurance. In addition, Core B will archive both biological specimens and test articles such as immunogens and mAbs used for passive immunization. These will be used as needed by the three projects and they will be shared with the larger research community upon request by other investigators. The three projects will have priority for receiving the specimens and test articles required to accomplish their specific aims. The Principal Investigator and Project Leaders will determine additional use of the specimens and test articles during regularly scheduled conference calls as specified in Core A. In the case of acute need, the decision will be made by an ad hoc conference call. The same team will establish priorities for external requests on an ad hoc basis for limited specimens or test articles. If the request is not for a limited material, it will be honored pro forma. Core B will also work closely with Core A where data will be archived to ensure that it can be readily tracked back to the specimens and test articles. The goals of Core B will be achieved by two specific aims. Aim 1: Provide specimens from immunized and challenged rhesus macaques. Aim 2: Provide antibody and protein reagents to the Program.