Core B-Specimen and Reagent Core

核心 B 样本和试剂核心

• 批准号: 9141191
• 负责人: WUYUAN LU
• 金额: $ 24.34万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9141191
• 关键词: Accountability; Acute; Antibodies; Antibody-mediated protection; Antigens; Archives; Back; Biological; Biological Assay; Biopsy; Cell Line; Cells; Communities; Core Protein; Data; Data Quality; Databases; Ensure; Foundations; Funding; Goals; Grant; HIV; HIV-1; Macaca mulatta; Monoclonal Antibodies; Passive Immunization; Peptides; Peripheral Blood Mononuclear Cell; Plasma; Population; Primates; Principal Investigator; Procedures; Protein Subunits; Proteins; Qualifying; Reagent; Research; Research Personnel; Resources; Sampling; Schedule; Source; Specific qualifier value; Specimen; T-Lymphocyte; Testing; Vaccinated; Work; base; env Gene Products; programs; quality assurance; rectal; symposium

The principal significance of Core B is that it will provide a centralized source for the receipt, tracking, storage, and distribution of valuable biological specimens generated by all three projects in addition to providing standardized research reagents to the projects. This will be accomplished using established standard operating procedures that are in place from our ongoing multi-project programs funded by grants from The Bill and Melinda Gates Foundation. This strategy strengthens the quality of data across the projects and provides a high-degree of accountability for quality assurance. In addition, Core B will archive both biological specimens and test articles such as immunogens and mAbs used for passive immunization. These will be used as needed by the three projects and they will be shared with the larger research community upon request by other investigators. The three projects will have priority for receiving the specimens and test articles required to accomplish their specific aims. The Principal Investigator and Project Leaders will determine additional use of the specimens and test articles during regularly scheduled conference calls as specified in Core A. In the case of acute need, the decision will be made by an ad hoc conference call. The same team will establish priorities for external requests on an ad hoc basis for limited specimens or test articles. If the request is not for a limited material, it will be honored pro forma. Core B will also work closely with Core A where data will be archived to ensure that it can be readily tracked back to the specimens and test articles. The goals of Core B will be achieved by two specific aims. Aim 1: Provide specimens from immunized and challenged rhesus macaques. Aim 2: Provide antibody and protein reagents to the Program.

Core B 的主要意义在于，它将为接收、跟踪、存储、 以及分发所有三个项目产生的有价值的生物标本，此外还提供 项目的标准化研究试剂。这将使用既定标准来完成 我们正在进行的由该法案拨款资助的多项目计划所制定的操作程序 和梅琳达·盖茨基金会。该策略增强了整个项目的数据质量，并提供 对质量保证的高度负责。此外，Core B 将存档这两种生物 用于被动免疫的标本和测试物品，例如免疫原和单克隆抗体。这些将是 三个项目根据需要使用，并将根据要求与更大的研究界共享 由其他调查人员。三个项目将优先接收标本和试品 需要完成他们的特定目标。首席研究员和项目负责人将确定 在定期安排的电话会议期间额外使用样本和测试物品，如 核心 A：在紧急需要的情况下，将通过临时电话会议做出决定。同一个团队 将针对有限的样本或测试物品临时确定外部请求的优先顺序。如果 请求不是针对有限的材料，我们将按形式予以尊重。核心B也将与核心A密切合作 数据将被存档，以确保可以轻松追溯到样本和测试物品。这 核心 B 的目标将通过两个具体目标来实现。目标 1：提供来自已免疫和 挑战恒河猴。目标 2：为该计划提供抗体和蛋白质试剂。