Core B-Specimen and Reagent Core

核心 B 样本和试剂核心

• 批准号: 9141191
• 负责人: WUYUAN LU
• 金额: $ 24.34万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9141191
• 关键词: Accountability; Acute; Antibodies; Antibody-mediated protection; Antigens; Archives; Back; Biological; Biological Assay; Biopsy; Cell Line; Cells; Communities; Core Protein; Data; Data Quality; Databases; Ensure; Foundations; Funding; Goals; Grant; HIV; HIV-1; Macaca mulatta; Monoclonal Antibodies; Passive Immunization; Peptides; Peripheral Blood Mononuclear Cell; Plasma; Population; Primates; Principal Investigator; Procedures; Protein Subunits; Proteins; Qualifying; Reagent; Research; Research Personnel; Resources; Sampling; Schedule; Source; Specific qualifier value; Specimen; T-Lymphocyte; Testing; Vaccinated; Work; base; env Gene Products; programs; quality assurance; rectal; symposium

The principal significance of Core B is that it will provide a centralized source for the receipt, tracking, storage, and distribution of valuable biological specimens generated by all three projects in addition to providing standardized research reagents to the projects. This will be accomplished using established standard operating procedures that are in place from our ongoing multi-project programs funded by grants from The Bill and Melinda Gates Foundation. This strategy strengthens the quality of data across the projects and provides a high-degree of accountability for quality assurance. In addition, Core B will archive both biological specimens and test articles such as immunogens and mAbs used for passive immunization. These will be used as needed by the three projects and they will be shared with the larger research community upon request by other investigators. The three projects will have priority for receiving the specimens and test articles required to accomplish their specific aims. The Principal Investigator and Project Leaders will determine additional use of the specimens and test articles during regularly scheduled conference calls as specified in Core A. In the case of acute need, the decision will be made by an ad hoc conference call. The same team will establish priorities for external requests on an ad hoc basis for limited specimens or test articles. If the request is not for a limited material, it will be honored pro forma. Core B will also work closely with Core A where data will be archived to ensure that it can be readily tracked back to the specimens and test articles. The goals of Core B will be achieved by two specific aims. Aim 1: Provide specimens from immunized and challenged rhesus macaques. Aim 2: Provide antibody and protein reagents to the Program.

核心B的主要意义在于，它将为收据，跟踪，存储， 以及所有三个项目产生的有价值的生物标本的分布，除了提供 项目的标准化研究试剂。这将使用既定标准来完成 我们正在进行的多项目计划中的操作程序由法案资助 和梅琳达·盖茨基金会。该策略加强了整个项目的数据质量，并提供了 高度的质量保证问责制。此外，核心B将归档两个生物学 标本和测试文章，例如用于被动免疫的免疫原子和mAB。这些将是 根据三个项目的需要使用，它们将根据要求与更大的研究社区共享 由其他调查员。这三个项目将优先接受标本和测试文章 需要实现其特定目标。首席调查员和项目负责人将确定 在规定的定期安排的电话会议中，额外使用样品和测试文章 核心A.在急需的情况下，该决定将由临时电话会议做出。同一个团队 将根据有限标本或测试文章的临时要求确定外部请求的优先级。如果是 请求不是针对有限的材料，它将受到尊敬的Pro Forma。核心B还将与核心A紧密合作 数据将存档以确保可以轻松地将其跟踪回标本和测试文章。这 核心B的目标将通过两个具体目标来实现。目标1：提供免疫和 挑战恒河猕猴。目标2：为该程序提供抗体和蛋白质试剂。