权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Determinants and Consequences of Frailty among Aging HIV-infected Persons

老年艾滋病毒感染者虚弱的决定因素和后果

基本信息

批准号：
9094445
负责人：
Damani Piggott
金额：
$ 18.28万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-01 至 2019-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9094445
关键词：
Accelerometer Acquired Immunodeficiency Syndrome African American Age Aging Award Biological Biological Factors Biological Markers Biology Body Composition Body Weight decreased C-reactive protein CD4 Lymphocyte Count Car Phone Caring Cessation of life Chronic Disease Clinical Clinical Investigator Communities Complex Data Development Development Plans Disease Elements Epidemiologic Factors Epidemiology Exercise Future Gait General Population Goals HIV HIV Infections Hand Strength Health Health Technology Health behavior Healthcare High Prevalence Hospitalization Inflammation Injecting drug user Institute of Medicine (U.S.)Institutes Institutionalization Interleukin-6 Intervention Intravenous Knowledge Life Life Expectancy Link Measurable Measures Medicine Mentorship Minority Modeling Monitor Morbidity - disease rate Outcome Participant Pathway interactions Pattern Persons Pharmaceutical Preparations Phenotype Physical activity Physiological Population Population Research Public Health Quality of life Recording of previous events Recovery Research Research Infrastructure Research Methodology Resources Risk Role Senior Scientist Social Behavior Staging Syndrome System TNFR-Fc fusion protein Technical Expertise Time Translating United States National Institutes of Health Universities Viral adverse outcome age related antiretroviral therapy base cardiorespiratory fitness career career development cohort collaborative environment design disability early experience effective intervention evidence base exercise intervention exhaustion experience frailty healthy aging high risk improved inflammatory marker innovation intervention effect mHealth member mortality muscle strength novel strategies patient oriented premature prevent public health relevance skills stressor therapy design therapy development

项目摘要

DESCRIPTION (provided by applicant): My career goal is to improve health outcomes for aging HIV-infected and at risk communities and to support the development of health promoting interventions tailored to socially marginalized, resource-constrained, and clinically vulnerable members of these communities. Frailty is an important age-related state of increased vulnerability to stressors that results in early death and a wide range of adverse age-associated clinical outcomes including increased hospitalization, disability, and institutionalization. Consequently, frailty has been identified by the Institute of Medicine as a top target priority are for health care improvement in the U.S. Early data have suggested an increased occurrence of frailty among aging HIV-infected persons. The epidemiologic and biological factors that determine transitions between frailty states (frailty progression and recovery) are not well-characterized. The proposed studies are nested in the AIDS Linked to the IntraVenous Experience (ALIVE) cohort, representing aging, minority injection drug users (IDUs) at the greatest risk for frailty-related consequences. Aim 1 utilizes longitudinal ALIVE data to examine the role of HIV and multimorbidity on frailty progression and recovery among aging HIV-infected and epidemiologically comparable HIV-uninfected IDUs. Aim 2 will longitudinally assess the relationship of inflammation-related biological markers with frailty transitions. Aim 3 will determine the feasibilty and define optimal trial elements for a mobile health (mHealth) enhanced exercise intervention to improve frailty parameters among aging HIV-infected persons. The proposed career development plan will expand my technical skills through additional expertise in the following domains: (1) transition modeling and analysis of complex longitudinal data; (2) application of mHealth technologies to health behavior promotion; (3) design and implementation of physical activity interventions for resource-constrained, frail, aging HIV-infected persons. I will be well supported within the Department of Medicine at Johns Hopkins University and will benefit from the excellent research infrastructure of the ALIVE study and other centers and institutes at Johns Hopkins University. With increasing survival but increased risk of multimorbid disease among aging HIV-infected populations, research on the epidemiologic and biological aspects of aging with HIV have become an NIH priority. Frailty represents an important age-related syndrome of significant

描述（由申请人提供）：我的职业目标是改善老年艾滋病毒感染者和高危社区的健康状况，并支持制定针对这些社区的社会边缘化，资源有限和临床弱势成员的健康促进干预措施。虚弱是一种重要的与年龄相关的状态，易受压力因素的影响，导致过早死亡和广泛的与年龄相关的不良临床结局，包括住院率增加，残疾和机构化。因此，虚弱已被医学研究所确定为美国改善医疗保健的首要目标。早期数据表明，老年艾滋病毒感染者中虚弱的发生率增加。决定虚弱状态（虚弱进展和恢复）之间转换的流行病学和生物学因素尚未得到很好的表征。拟议的研究嵌套在与静脉注射经验相关的艾滋病（ALIVE）队列中，代表老年人，少数注射吸毒者（IDUs），脆弱相关后果的风险最大。目的1利用纵向ALIVE数据来研究HIV和多药耐药在老年HIV感染者和流行病学上可比的未感染艾滋病毒的注射吸毒者。目标2将纵向评估炎症相关的生物标志物与脆弱的转变。目标3将确定移动的健康（mHealth）增强运动干预的可行性并定义最佳试验要素，以改善老年艾滋病毒感染者的虚弱参数。拟议的职业发展计划将通过以下领域的额外专业知识来扩展我的技术技能：（1）复杂纵向数据的过渡建模和分析;（2）移动健康技术在健康行为促进中的应用;（3）为资源有限，虚弱，老龄化的艾滋病毒感染者设计和实施身体活动干预措施。我将在约翰霍普金斯大学医学系得到很好的支持，并将受益于ALIVE研究和约翰霍普金斯大学其他中心和研究所的优秀研究基础设施。随着老年艾滋病毒感染人群的生存率提高，但患多病的风险增加，对艾滋病毒感染者衰老的流行病学和生物学方面的研究已成为NIH的优先事项。虚弱是一种重要的年龄相关综合征，