General Surgical Pathology

普通外科病理科为NIH临床中心提供临床外科病理诊断服务，从而为整个NIH社区提供服务。所用的诊断方法包括苏木精和伊红为基础的组织学，和辅助研究，如免疫组织化学，分子遗传学研究，和组织为基础的荧光原位杂交。本节中临床医生遇到的疾病过程的广度很广，包括癌症、良性肿瘤、传染病、退行性疾病和衰老过程、发育障碍、心脏和循环系统疾病以及遗传疾病。评估的许多标本来自患有罕见甚至未确诊疾病的独特患者群体。因此，这些来自活组织检查和外科手术切除的临床组织以及相应的患者临床信息沿着构成了该科临床工作人员合作研究项目的丰富资源。此外，它们被用作病理学实验室备受推崇的ACGME认证培训计划中解剖病理学居民培训的重要组成部分。在这一年里，我们参与了与混合神经鞘瘤有关的神经外科研究项目，肾上腺癌IL 13受体表达的研究，以及间皮瘤异种移植和BAP 1突变的研究项目。

The Section of General Surgical Pathology provides clinical surgical pathology diagnostic services to the NIH Clinical Center, and thereby to the entire NIH community. The diagnostic modalities utilized include hematoxylin and eosin-based histology, and adjunct studies such as immunohistochemistry, molecular genetic studies, and tissue-based fluorescence in situ hybridization. The breadth of disease processes encountered by clinicians in this Section is wide, and includes cancer, benign tumors, infectious diseases, degenerative diseases and the aging process, developmental disorders, diseases of the heart and circulatory system, and genetic diseases. Many of the specimens evaluated derive from unique populations of patients with rare or even undiagnosed diseases. Accordingly these clinical tissues from biopsies and surgical resections, along with the corresponding patient clinical information, comprise a resource rich for collaborative research projects for the clinical staff in the Section. In addition, they are utilized as an essential component in the training of Anatomic Pathology residents in the Laboratory of Pathology's well-regarded ACGME-accredited Training Program. During the year we participated in neurosurgical research project related to hybrid schwannomas, studies on adrenal carcinomas on IL13 receptor expression, and in projects on mesothelioma xenografts and BAP1 mutations.