INTEGRATED HEALTH SCIENCE

综合健康科学设施核心(IHSFC)的主要目标是促进 CTEHR将基础科学研究转化为人类人口和临床研究，并将其“反向翻译” 将人类研究的发现转化为新的假设驱动的基于实验室的研究。为了增强我们的 了解疾病的环境基础，优化检测、预防和/或管理 对于环境暴露引起或加剧的疾病，IHSFC将提供： �优先访问组织存储库并开发用于虚拟人体研究的协议 存储库和协议开发(VRPD)服务； 人微生物区系和人源化小鼠世代的�特征和元基因组图谱 利用微生物组和灵生(MG)资源和 �获得具有代谢表型(MP)能力的组织和个人的代谢概况。 IHSFC将为中心成员提供“翻译导航员”，这些成员将贡献独特的专业知识 并促进CTEHR调查人员有效利用IHSFC资源。翻译导航员将 还指导和促进中心成员优先访问IHSFC资源。为了完成核心任务 为了实现这些目标，我们提出了以下具体目标： 目标1.通过下列服务和资源提供服务和使用仪器和技术 促进(反向)将基础科学转化为公共卫生研究，包括流行病学， 与环境暴露和疾病有关的预防和干预研究。 目标2.通过提供培训和职业发展，进一步支持儿童权利委员会的教育使命 与职业发展计划合作，面向中心成员和实习生。 目标3.加强和“引导”研究人员和社区之间的伙伴关系，以影响 通过与社区外展中心的联系开展临床和公共卫生研究 参与核心(COEC)。 IHSFC将成为创新的催化剂，并为CTEHR成员提供独特的资源，充分利用- 配备实验室、建立基础设施、样本档案和专业知识，以促进EHS研究。

The primary goal of the Integrative Health Sciences Facility Core (IHSFC) is to facilitate translation of CTEHR research in the basic sciences into human population and clinical studies, and to "reverse translate" findings from human studies into new hypothesis-driven laboratory-based research. To enhance our understanding of the environmental basis of disease, and optimize detection, prevention and/or management of diseases induced or exacerbated by environmental exposures, the IHSFC will provide: � Prioritized access to tissue repositories and development of protocols for human research with Virtual Repository and Protocol Development (VRPD) service; � Characterization and metagenomic profiling of human microbiota and generation of humanized mice with a Microbiome and Gnotobiotic (MG) resource and � Access to metabolic profiling of tissues and individuals with Metabolic Phenotyping (MP) capability. The IHSFC will provide "Translational Navigators" for Center members, who will contribute unique expertise and facilitate effective utilization of IHSFC resources by CTEHR investigators. Translational Navigators will also direct and facilitate "priority" access to IHSFC resources by Center members. In order to accomplish Core goals, we propose the following Specific Aims: Aim 1. Provide services and access to instrumentation and technologies through services and resources that foster (reverse) translation of basic science into public health research, including epidemiology, prevention and intervention studies as they relate to environmental exposures and diseases. Aim 2. Further support the educational mission of the CTEHR by providing training and career development for Center members and trainees in collaboration with the Career Development Program. Aim 3. Enhance and "navigate" partnerships between researchers and the community that impact on conducting clinical and public health research through linkages with the Community Outreach and Engagement Core (COEC). The IHSFC will be a catalyst for innovation and provide unique resources to CTEHR members, leveraging well- equipped laboratories, established infrastructure, sample archives and expertise to facilitate EHS research.