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中文摘要
翻译
描述(由申请人提供):本提案要求部分支持第四届戈登研究会议(GRC)的认知神经生物学及其相关的戈登研究研讨会(GRS)的学员。GRC背后的驱动力是分子,细胞电路和系统神经科学中聚合发现的快速发展,并通过在复杂的认知任务中同时监测和操纵广泛大脑区域活动的技术发展得到增强。这些发展与允许细胞靶向和计算方法的遗传操作相结合,为神经元回路和动力学,神经生理过程和认知功能基础的计算原理的描述提供了基础。该研究中心的目标是继续促进在该领域工作的实证科学家和理论家之间的相关分析水平的沟通和合作,强调最新的研究结果。在GRC之前举行的相关GRS旨在为博士和博士后学员提供交流他们最新研究结果和观点的机会,并为他们更深入地参与紧随其后的家长GRC做好准备。该GRC的重要特征之一是几位领先的临床科学家的参与,他们对脑损伤引起的各种认知障碍具有独特的临床观点,并对他们的工作提供了正常认知功能的见解。总体而言,该计划是高度跨学科的,将行为,神经成像,电生理技术和针对特定细胞类型的操作与旨在构建认知操作的现实模型的计算方法结合在一起。会议的形式促进了来自不同角度和分析水平的调查人员和学员之间的密切互动,特别是临床医生,实验人员和理论家之间的互动。
英文摘要
DESCRIPTION (provided by applicant): This proposal requests partial support for the fourth Gordon Research Conference (GRC) on the Neurobiology of Cognition and for its associated Gordon Research Seminar (GRS) for trainees. The driving force behind the GRC is the rapid pace of convergent findings in molecular, cellular circuit and systems neuroscience, augmented by technical developments in simultaneously monitoring and manipulating activity across wide brain regions during complex cognitive tasks. These developments combined with genetic manipulations allowing cell-targeting and computational approaches provide the basis for evolving descriptions of neuronal circuits and dynamics, neurophysiological processes and computational principles underlying cognitive functions. The goal of this GRC is to continue promoting communication and collaboration across relevant levels of analysis among empirical scientists and theoreticians working in the field, emphasizing the most recent findings. The associated GRS, held just prior to the GRC, is designed to provide opportunities for doctoral and post-doctoral trainees to communicate their most recent findings and perspectives, and to prepare them for more in-depth participation in the parent GRC that immediately follows. One of the important features of this GRC is participation of several leading clinician-scientists with unique clinical perspective on a variety of cognitive disorders caused by brain damage and insights into normal cognitive function their work provides. Overall, the program is highly interdisciplinary, bringing together behavioral, neuroimaging, electrophysiological techniques and manipulations targeting specific cell types with computational approaches aimed at constructing realistic models of cognitive operations. The format of the meeting promotes intensive interactions among investigators and trainees from different perspectives and analytic levels, and in particular, between clinicians, experimentalists and theorists.
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CORTICAL SUBSTRATES OF WORKING MEMORY FOR VISUAL MOTION
  • 批准号:
    8877974
  • 项目类别:
  • 资助金额:
    $3.7万
  • 财政年份:
    2014
  • 负责人:
    TATIANA PASTERNAK
  • 依托单位:
IMAGING MODULE
  • 批准号:
    7690021
  • 项目类别:
  • 资助金额:
    $12.68万
  • 财政年份:
    2008
  • 负责人:
    TATIANA PASTERNAK
  • 依托单位:
CORE--HISTOLOGY
  • 批准号:
    6713449
  • 项目类别:
  • 资助金额:
    $5.74万
  • 财政年份:
    2003
  • 负责人:
    TATIANA PASTERNAK
  • 依托单位:
CORE--HISTOLOGY
  • 批准号:
    6580404
  • 项目类别:
  • 资助金额:
    $13.16万
  • 财政年份:
    2002
  • 负责人:
    TATIANA PASTERNAK
  • 依托单位:
国内基金
海外基金
新型F-18标记香豆素衍生物PET探针的研制及靶向Alzheimer's Disease 斑块显像研究
  • 批准号:
    81000622
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    20.0万元
  • 批准年份:
    2010
  • 负责人:
    梁胜
  • 依托单位:
阿尔茨海默病(Alzheimer's disease,AD)动物模型构建的分子机理研究
  • 批准号:
    31060293
  • 项目类别:
    地区科学基金项目
  • 资助金额:
    26.0万元
  • 批准年份:
    2010
  • 负责人:
    郭亚芬
  • 依托单位:
跨膜转运蛋白21(TMP21)对引起阿尔茨海默病(Alzheimer'S Disease)的γ分泌酶的作用研究