UZ-UCSF CTU

描述（由申请人提供）：津巴布韦大学-加州大学弗朗西斯科分校合作研究计划（UZUCSF）与加州大学弗朗西斯科分校（UCSF）合作，是一个完善的大型临床试验单位（CTU）的所在地，拥有4个临床研究中心（CRS），覆盖津巴布韦哈拉雷及其周边的6个不同地理位置。领导和参与4个艾滋病司（DAIDS）网络（HPTN，MTN，ACTG，IMPAACT）的经验，使CTU能够继续作为预防和控制艾滋病毒和艾滋病的卓越研究中心，为全球了解艾滋病毒流行病学和发病机制做出贡献。利用我们的国际和当地调查人员以及训练有素和经验丰富的研究人员的专业知识，CTU将通过完成以下具体目标来实现这一目标：识别、筛选、招募和保留现有和新的 在流行率和发病率下降的环境中，在以下4个未来NIAID赞助的网络的科学优先任务特定领域中， 以及肝炎和结核病的传染性并发症; ㈡防治艾滋病毒和 儿童和孕产妇人群中的艾滋病毒相关感染; iii）艾滋病毒综合预防战略; iv）预防艾滋病毒感染的杀微生物剂战略，以及1.b.为NIAID赞助的4个未来网络的科学领导做出贡献。2.利用日益高效和复杂的集中管理结构，支持在4个重组的CRS、实验室和药房组件中不间断地执行方案。3.利用与CTU的社区合作伙伴和不同利益相关者建立的整体关系，传播研究成果，并将研究成果转化为地方，区域和国际层面的循证最佳实践和政策。 相关性：反恐股在四个网络中执行议定书的工作可能产生成果，转化为津巴布韦国内和国际上减少艾滋病毒发病率和流行率的政策。CTU预计，这一新证据将进一步为政策提供信息，以将津巴布韦的艾滋病毒发病率从目前的3%降至2%;将目前的艾滋病毒流行率从13%降至7.5%;将艾滋病毒垂直传播从目前的14%降至<5%;并将结核病发病率从每10万人633例降至每10万人200例。

DESCRIPTION (provided by applicant): The University of Zimbabwe-University of California, San Francisco Collaborative Research Programme (UZUCSF), in collaboration with the University of California, San Francisco (UCSF), is the site of a well-established, large Clinical Trials Unit (CTU) with 4 Clinical Research Sites (CRSs), covering 6 distinct geographic locations within and surrounding Harare, Zimbabwe. Experience gained from leadership and participation in 4 Division of AIDS (DAIDS) Networks (HPTN, MTN, ACTG, IMPAACT), positions the CTU to continue its contribution to the global understanding of HIV epidemiology and pathogenesis by serving as a center of research excellence in the prevention and control of HIV and AIDS. Utilizing the expertise of our international and local complement of investigators and highly trained and experienced research personnel, the CTU will accomplish this through completion of the following Specific Aims: 1.a. Identifying, screening, enrolling, and retaining existing and new at-risk populations in an environment of declining prevalence and incidence, in the following mission-specific domains of scientific priority of the 4 future NIAID-sponsored Networks: i) Adult HIV Therapeutic Strategies, including HIV cure, noninfectious comorbidities, and the infectious co-morbidities of hepatitis and tuberculosis; ii) Strategies to Address HIV and HIV-associated Infections in Pediatric and Maternal Populations; iii) Integrated HIV Prevention Strategies; and iv) Microbicide Strategies to Prevent HIV infections, and 1.b. Contributing to the scientific leadership of the 4 future NIAID-sponsored Networks. 2. Utilizing an increasingly efficient and sophisticated centralized administrative structure to support the uninterrupted execution of protocols across 4 restructured CRSs, laboratory, and pharmacy components. 3. Leveraging the integral relationships developed with the CTU's community partners and diverse stakeholders to disseminate research findings and translate research results into evidence-based best practices and policies at the local, regional, and international levels. RELEVANCE: The CTU's implementation of protocols across the 4 Networks may produce results that translate to policies within Zimbabwe and internationally to reduce HIV incidence and prevalence. The CTU anticipates that this new evidence will further inform policies to reduce the Zimbabwean HIV incidence from its current 3% to 2%; reduce current HIV prevalence from 13% to 7.5%; reduce HIV vertical transmission from the current 14% to <5%; and reduce TB incidence from 633 per 100,000 persons to 200 per 100,000.