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中文摘要
翻译
创伤性颈段脊髓损伤可导致该水平以下的永久性和广泛性瘫痪 受伤,造成多种身体功能的丧失,包括手,躯干和腿部运动,膀胱和 排便控制和呼吸能力这个项目的目标是恢复这些多功能, 通过全面的神经修复方法,解决个人的整体需求, 单独的.这种方法涉及实施的各个方面,包括植入技术、 手术安装,并通过协调的团队方法进行结果评估, 最大限度地提高个人获得的功能独立性。通过这个系统,我们打算提供 中颈段脊髓损伤的患者,控制抓握、伸展、咳嗽、内翻 床、坐姿和膀胱功能。这一雄心勃勃而令人兴奋的目标是由 我们的研究和临床部署的神经假体系统脊髓损伤的高潮 过去30年的研究课题和我们先进的神经假体的开发。我们预计 该系统不仅将增加每个目标身体功能的独立性,而且将 提供总体益处,以证明生活质量和健康结果的显著改善。 在脊髓损伤受试者的临床可行性研究中,我们的临床研究团队 证明了双侧手功能的控制、滚动和姿势控制、咳嗽、膀胱控制和 使用长期植入的神经假体进行排便控制。每项临床研究的结果都表明, 每个系统都为个人提供了更多的功能独立性。然而,在这一点上, 不可能满足每个人的整体需求,并制定一个全面的方法, 功能获得。通过开发网络化神经假体系统(NNPS),我们现在 拥有多功能系统的技术基础。本U01项目采用的策略是 最终确定我们提出的整体神经修复方法的关键组成部分。因此, 方法,包括技术、监管批准、手术安装、结果评估和 总体执行,将在本项目期间完成,最终执行 脊髓损伤患者的多功能NNPS。这个项目的最终结果是,我们将 证明使用一种方法解决严重残疾人多重残疾问题的可行性, 先进的神经假体系统,加上精简和连贯的实施战略。
英文摘要
Traumatic cervical-level spinal cord injury can result in permanent and extensive paralysis below the level of injury, causing the loss of multiple body functions, including hand, trunk and leg movement, bladder and bowel control, and respiratory capacity. The goal of this project is to restore these multiple functions to these individuals through a comprehensive neuroprosthetic approach that addresses the overall needs of the individual. This approach involves all aspects of the implementation, including the implanted technology, the surgical installation, and the outcomes assessment through a coordinated team approach in order to maximize the functional independence gained by the individual. With this system, we intend to provide individuals who have a mid-cervical level spinal cord injury with control over grasp, reach, cough, turning in bed, seated posture, and bladder function. This ambitious and exciting goal is made possible by the culmination of our research and clinical deployment of neuroprosthetic systems for spinal cord injured subjects over the past 30 years and our development of an advanced neuroprosthesis. We anticipate that this system will not only provide increased independence in each of the targeted body functions, but will provide an overall benefit to demonstrate significant improvements in quality of life and health outcomes. In clinical feasibility studies with spinal cord injured subjects, our clinical research teams have demonstrated the control of bilateral hand function, rolling and postural control, cough, bladder control and bowel control using chronically implanted neuroprostheses. Outcomes from each clinical study demonstrate that each system provides increased functional independence to the individual. However, to this point, it has not been possible to address each individual's holistic needs and tailor an overall approach that maximizes the function gained. Through the development of a Networked Neuroprosthetic System (NNPS), we now have the technological foundation for a multi-functional system. The strategy employed in this U01 project is to finalize the key components of our proposed holistic neuroprosthetic approach. Thus, each component of the approach, including the technology, regulatory approvals, surgical installation, outcome assessment and overall implementation, will be brought to completion during this project, culminating in the implementation of the multi-function NNPS in spinal cord injured subjects. The ultimate outcome of this project is that we will demonstrate the feasibility of addressing multiple disabilities in severely disabled individuals using an advanced neuroprosthetic system coupled with a streamlined and cohesive implementation strategy.
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Multi-functional Neuroprosthetic Systems for Restoration of Motor Function
  • 批准号:
    8892371
  • 项目类别:
  • 资助金额:
    $13.5万
  • 财政年份:
    2010
  • 负责人:
    Paul Hunter Peckham
  • 依托单位:
Multi-functional Neuroprosthetic Systems for Restoration of Motor Function
  • 批准号:
    7868615
  • 项目类别:
  • 资助金额:
    $149.75万
  • 财政年份:
    2010
  • 负责人:
    Paul Hunter Peckham
  • 依托单位:
Multi-functional Neuroprosthetic Systems for Restoration of Motor Function
  • 批准号:
    8287028
  • 项目类别:
  • 资助金额:
    $139.89万
  • 财政年份:
    2010
  • 负责人:
    Paul Hunter Peckham
  • 依托单位:
Multi-functional Neuroprosthetic Systems for Restoration of Motor Function
  • 批准号:
    8080292
  • 项目类别:
  • 资助金额:
    $141.02万
  • 财政年份:
    2010
  • 负责人:
    Paul Hunter Peckham
  • 依托单位:
海外基金