Multi-functional Neuroprosthetic Systems for Restoration of Motor Function
Multi-functional Neuroprosthetic Systems for Restoration of Motor Function
批准号:
8689184
负责人:
Paul Hunter Peckham
金额:
$133.39万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-06-01 至 2018-05-31
关键词:
AddressAdvanced DevelopmentBedsBilateralBladderBladder ControlCervicalCervical spinal cord injuryClinicalClinical ResearchCoughingCoupledDevelopmentDisabled PersonsFeasibility StudiesFoundationsFundingGoalsHandHand functionsHealthHumanImplantIndividualInjuryInstructionIntestinesLegMotorMovementMusculoskeletal EquilibriumOperative Surgical ProceduresOutcomeOutcome AssessmentParalysedPosturePreparationQuadriplegiaQuality of lifeResearchSpinal cord injurySystemTechniquesTechnologyTestingbasefunctional gainfunctional outcomesgain of functiongrasphand grasphuman subjectimplantationin vivomeetingsmultiple disabilityneuroprosthesispreclinical studyrespiratoryrestoration
中文摘要
创伤性颈椎水平脊髓损伤可导致颈椎节段以下的永久性和广泛性瘫痪。
造成多种身体功能的丧失,包括手、躯干和腿的运动,膀胱和
大便控制和呼吸能力。该项目的目标是将这些多重功能恢复为
通过一种全面的神经假体方法解决个人的总体需求
个人的。这种方法涉及实施的所有方面,包括植入的技术、
手术安装,以及通过协调的团队方法进行结果评估,以便
最大限度地提高个人获得的功能独立性。通过这个系统,我们打算提供
有颈中水平脊髓损伤并控制抓握、伸展、咳嗽、翻身的个人
床、坐姿和膀胱功能。这一雄心勃勃而激动人心的目标是由
脊髓损伤神经假体系统研究和临床应用的高潮
受试者在过去的30年里和我们开发了一种先进的神经假体。我们预料到
这一系统不仅将提高每一目标机构职能的独立性,而且将
提供总体利益,以显示生活质量和健康结果的显著改善。
在脊髓损伤受试者的临床可行性研究中,我们的临床研究团队
展示了双侧手功能的控制,翻滚和姿势控制,咳嗽,膀胱控制和
使用长期植入的神经假体进行肠道控制。每项临床研究的结果都表明
每个系统都为个人提供了更多的功能独立性。然而,在这一点上,它已经
不可能解决每个人的整体需求并量身定做一种最大化地
获得的功能。通过开发网络神经假体系统(NNPS),我们现在
具备多功能系统的技术基础。这个U01项目采用的策略是
最终确定我们建议的整体神经假体方法的关键组成部分。因此,每个组件
方法,包括技术、监管批准、手术安装、结果评估和
总体实施,将在本项目期间完成,最终将实施
脊髓损伤受试者的多功能NNPS。这个项目的最终结果是,我们将
演示在严重残疾人群中使用
先进的神经假体系统与精简和连贯的实施策略相结合。
英文摘要
Traumatic cervical-level spinal cord injury can result in permanent and extensive paralysis below the level
of injury, causing the loss of multiple body functions, including hand, trunk and leg movement, bladder and
bowel control, and respiratory capacity. The goal of this project is to restore these multiple functions to these
individuals through a comprehensive neuroprosthetic approach that addresses the overall needs of the
individual. This approach involves all aspects of the implementation, including the implanted technology, the
surgical installation, and the outcomes assessment through a coordinated team approach in order to
maximize the functional independence gained by the individual. With this system, we intend to provide
individuals who have a mid-cervical level spinal cord injury with control over grasp, reach, cough, turning in
bed, seated posture, and bladder function. This ambitious and exciting goal is made possible by the
culmination of our research and clinical deployment of neuroprosthetic systems for spinal cord injured
subjects over the past 30 years and our development of an advanced neuroprosthesis. We anticipate that
this system will not only provide increased independence in each of the targeted body functions, but will
provide an overall benefit to demonstrate significant improvements in quality of life and health outcomes.
In clinical feasibility studies with spinal cord injured subjects, our clinical research teams have
demonstrated the control of bilateral hand function, rolling and postural control, cough, bladder control and
bowel control using chronically implanted neuroprostheses. Outcomes from each clinical study demonstrate
that each system provides increased functional independence to the individual. However, to this point, it has
not been possible to address each individual's holistic needs and tailor an overall approach that maximizes
the function gained. Through the development of a Networked Neuroprosthetic System (NNPS), we now
have the technological foundation for a multi-functional system. The strategy employed in this U01 project is
to finalize the key components of our proposed holistic neuroprosthetic approach. Thus, each component of
the approach, including the technology, regulatory approvals, surgical installation, outcome assessment and
overall implementation, will be brought to completion during this project, culminating in the implementation of
the multi-function NNPS in spinal cord injured subjects. The ultimate outcome of this project is that we will
demonstrate the feasibility of addressing multiple disabilities in severely disabled individuals using an
advanced neuroprosthetic system coupled with a streamlined and cohesive implementation strategy.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
Multi-functional Neuroprosthetic Systems for Restoration of Motor Function
-
批准号:8892371
-
项目类别:
-
资助金额:$13.5万
-
财政年份:2010
-
负责人:Paul Hunter Peckham
-
依托单位:
Multi-functional Neuroprosthetic Systems for Restoration of Motor Function
-
批准号:7868615
-
项目类别:
-
资助金额:$149.75万
-
财政年份:2010
-
负责人:Paul Hunter Peckham
-
依托单位:
Multi-functional Neuroprosthetic Systems for Restoration of Motor Function
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批准号:8287028
-
项目类别:
-
资助金额:$139.89万
-
财政年份:2010
-
负责人:Paul Hunter Peckham
-
依托单位:
Multi-functional Neuroprosthetic Systems for Restoration of Motor Function
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批准号:8080292
-
项目类别:
-
资助金额:$141.02万
-
财政年份:2010
-
负责人:Paul Hunter Peckham
-
依托单位:
Multi-functional Neuroprosthetic Systems for Restoration of Motor Function
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批准号:8471794
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项目类别:
-
资助金额:$134.58万
-
财政年份:2010
-
负责人:Paul Hunter Peckham
-
依托单位:
Neural Interfaces Conference
-
批准号:7501414
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项目类别:
-
资助金额:$0.5万
-
财政年份:2007
-
负责人:Paul Hunter Peckham
-
依托单位:
Neural Interfaces Conference
-
批准号:7334507
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项目类别:
-
资助金额:$2.5万
-
财政年份:2007
-
负责人:Paul Hunter Peckham
-
依托单位:
Neural Interfaces Conference
-
批准号:8265033
-
项目类别:
-
资助金额:$1.5万
-
财政年份:2007
-
负责人:Paul Hunter Peckham
-
依托单位:
Neural Interfaces Conference
-
批准号:7673893
-
项目类别:
-
资助金额:$1.5万
-
财政年份:2007
-
负责人:Paul Hunter Peckham
-
依托单位:
Neural Interfaces Conference
-
批准号:8495480
-
项目类别:
-
资助金额:$3.0万
-
财政年份:2007
-
负责人:Paul Hunter Peckham
-
依托单位:
Neural Interfaces Conference
-
批准号:7555979
-
项目类别:
-
资助金额:$12.49万
-
财政年份:2007
-
负责人:Paul Hunter Peckham
-
依托单位:
Neural Interfaces Conference
-
批准号:8137242
-
项目类别:
-
资助金额:$11.0万
-
财政年份:2007
-
负责人:Paul Hunter Peckham
-
依托单位:
Neural Interfaces Conference
-
批准号:7915327
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2007
-
负责人:Paul Hunter Peckham
-
依托单位:
Neural Interfaces Conference
-
批准号:7777027
-
项目类别:
-
资助金额:$1.0万
-
财政年份:2007
-
负责人:Paul Hunter Peckham
-
依托单位:
STIMULATION SYSTEM FOR CONTROL OF THE PARALYZED HAND IN THE C5/C6 INJURY
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批准号:7378081
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项目类别:
-
资助金额:$13.41万
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财政年份:2006
-
负责人:Paul Hunter Peckham
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依托单位:
STIMULATION SYSTEM FOR CONTROL OF THE PARALYZED HAND IN THE C5/C6 INJURY
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批准号:7202804
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项目类别:
-
资助金额:$9.52万
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财政年份:2005
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负责人:Paul Hunter Peckham
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依托单位:
Restoration of hand-arm function with neuroprosthesis
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批准号:7125781
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项目类别:
-
资助金额:$22.81万
-
财政年份:2005
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负责人:Paul Hunter Peckham
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依托单位:
Myoelectric control of a hand grasp neuroprosthesis of C7 tetraplegia
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批准号:6974908
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项目类别:
-
资助金额:$0.07万
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财政年份:2004
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负责人:Paul Hunter Peckham
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依托单位:
Development of Networked Implantable Neuroprostheses
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批准号:8846111
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项目类别:
-
资助金额:$61.2万
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财政年份:2001
-
负责人:Paul Hunter Peckham
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依托单位:
Development of Networked Implantable Neuroprostheses
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批准号:7217332
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项目类别:
-
资助金额:$132.49万
-
财政年份:2001
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负责人:Paul Hunter Peckham
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依托单位:
海外基金