Core B - Hauser

生物统计学和生物信息学核心（“核心B”/核心001） 项目摘要 该核心负责提供数据管理，数据质量控制和多元， 结构和临床建模的项目。整个计划，开发超过25年的NHLBI 在支持下，产生了大量的数据、结果、分析和手稿， 遗传变异、心理社会压力、行为和生理内表型之间的相互作用， 心脏代谢疾病的途径和不良临床病程。同样，数据集的数量 为这些活动做出贡献，这些数据集中的个人数量随着时间的推移而增加， 在更新期间，我们建议在非常大的数据集上进行工作。生物统计学核心负责 顺利管理并向项目提供这些数据。基因组科学的持续进步 已经导致了可用于确定遗传决定因素的资源和工具的巨大扩展， 复杂的心脏代谢疾病。我们之前的工作已经证明，包括以下因素的影响至关重要： 环境压力（G x E）。剖析这些特征的遗传基础不仅需要 技术进步，而且还可以获得具有适当特征的研究人群 环境措施。此外，G x E效应的建模需要综合统计 这些特征的生物学和流行病学的方法和专业知识。提供无缝集成 核心B的高级信息支持成员作为项目团队成员参与， 参与核心活动。生物统计学和生物信息学核心的目标是： 1)根据需要提供数据管理和数据质量控制，以促进本PPG中的四个项目 计划的各个方面; 2)提供统计分析、电脑程式设计及生物资讯方面的意见及支援， 项目; 3)协调跨两个或多个项目的综合分析。

Biostatistics and Bioinformatics Core (“Core B”/Core 001) PROJECT SUMMARY This Core is responsible for providing expertise in data management, data quality control, and multivariate, structural and clinical modeling to the Projects. The overall Program, developed over 25 years of NHLBI support, has generated a significant amount of data, results, analyses and manuscripts that identify interactions between genetic variation, psychosocial stress, behavioral and physiological endophenotypes, in pathways to cardiometabolic disease and adverse clinical course. Likewise, the number of datasets contributing to these activities and the number of individuals in these datasets has increased over time such that in the renewal period we propose work on very large datasets. The Biostatistics Core is responsible for the smooth management and availability of those data to the projects. Continued advances in genome sciences have resulted in a vast expansion of the resources and tools available to identify the genetic determinants of complex cardiometabolic diseases. Our prior work has demonstrated that it is critical to include the effects of environmental stressors (G x E) in these analyses. Dissecting the genetic basis of these traits requires not only technological advances, but also access to well-characterized study populations that have appropriate environmental measures. In addition, the modeling of G x E effects requires integrated statistical methodologies and expertise in the biology and epidemiology of these traits. To provide seamless integration and a high-level of informatics support members of Core B participate as Project team members as well as participate in Core activities. The Aims of the Biostatistics and Bioinformatics Core are: 1) To facilitate the four Projects in this PPG by providing data management and data quality control as needed for all aspects of the Program; 2) To provide advice and support for statistical analysis, computer programming and bioinformatics to the Projects; 3) To coordinate integrated analyses that cross two or more Projects.