Anti-Inflammatory Therapeutics for Cardiovascular Disease

心血管疾病的抗炎治疗

• 批准号: 9402969
• 负责人: SAMUEL A WICKLINE
• 金额: $ 44.19万
• 依托单位: UNIVERSITY OF SOUTH FLORIDA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-20 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9402969
• 关键词: Anti; Inflammatory; Therapeutics; Cardiovascular; Disease

DESCRIPTION (provided by applicant): Inflammation in atherosclerotic plaque is a key promoter of acute vascular syndromes (i.e., thrombosis). Panoply of cytokines, growth factors, and immune cellular infiltrates converges to dramatically enhance the local thrombogenic potential of unstable plaques by creating a hypercoagulant, tissue factor-rich milieu that is exposed by either plaque rupture or erosion, which results in vessel occlusion and hypoxic tissue death. The overarching theme of our continuing multidisciplinary translational effort is the development and clinical testing of nanoparticle based approaches for the diagnosis and therapy of thrombotic cardiovascular diseases to detect, treat, and monitor unstable atheroma. The initial phase of the program was devoted to novel molecular imaging strategies that have culminated in FDA approved clinical trials of integrin-targeted nanoparticles for plaque angiogenesis detection. In the next phase of the work, we seek to develop and quantify the efficacy of new nanotherapeutic agents to attenuate plaque inflammation with the clinical goal of reducing the propensity toward thrombosis in acute vascular syndromes. We will evaluate the following overarching hypothesis: anti- inflammatory therapeutic nanoparticles can modulate the hyperthrombotic state in acute vascular syndromes and restore stability in atherosclerotic lesions with benefits over and above conventional therapy. The specific aims are to: I. Design, formulate, and evaluate targeted anti-inflammatory nanotherapies in vitro II. Test therapeutic formulations in vivo in a standardized ApoE -/-mouse thrombosis model III. Test nanoparticle combinations and multiplexed nanoparticles in vivo for synergistic efficacy

描述（由申请人提供）：动脉粥样硬化斑块中的炎症是急性血管综合征（即血栓形成）的关键促进因素。细胞因子、生长因子和免疫细胞的浸润，通过形成高凝、组织因子丰富的环境，显著增强不稳定斑块的局部血栓形成潜力，斑块破裂或侵蚀暴露，导致血管闭塞和缺氧组织死亡。我们持续的多学科翻译工作的首要主题是

项目成果

Nanotechnology in interventional cardiology.

• DOI: 10.1002/wnan.154
• 发表时间: 2012-01
• 期刊: WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
• 影响因子: 8.6
• 作者: Cyrus, Tillmann;Wickline, Samuel A.;Lanza, Gregory M.
• 通讯作者: Lanza, Gregory M.

Detecting vascular biosignatures with a colloidal, radio-opaque polymeric nanoparticle.

• DOI: 10.1021/ja906797z
• 发表时间: 2009-10-28
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Pan D;Williams TA;Senpan A;Allen JS;Scott MJ;Gaffney PJ;Wickline SA;Lanza GM
• 通讯作者: Lanza GM

Assessing intrarenal nonperfusion and vascular leakage in acute kidney injury with multinuclear (1) H/(19) F MRI and perfluorocarbon nanoparticles.

• DOI: 10.1002/mrm.24851
• 发表时间: 2014-06
• 期刊: MAGNETIC RESONANCE IN MEDICINE
• 影响因子: 3.3
• 作者: Hu, Lingzhi;Chen, Junjie;Yang, Xiaoxia;Senpan, Angana;Allen, John S.;Yanaba, Noriko;Caruthers, Shelton D.;Lanza, Gregory M.;Hammerman, Marc R.;Wickline, Samuel A.
• 通讯作者: Wickline, Samuel A.

Simultaneous Inhibition of Thrombosis and Inflammation Is Beneficial in Treating Acute Myocardial Infarction.

• DOI: 10.3390/ijms24087333
• 发表时间: 2023-04-15
• 期刊: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
• 影响因子: 5.6
• 作者: Vargas, Ian;Grabau, Ryan P.;Chen, Junjie;Weinheimer, Carla;Kovacs, Attila;Dominguez-Viqueira, William;Mitchell, Adam;Wickline, Samuel A.;Pan, Hua
• 通讯作者: Pan, Hua

Noninvasive detection of transplant coronary artery disease with contrast-enhanced cardiac MRI in pediatric cardiac transplants.

在儿科心脏移植中使用对比增强心脏 MRI 无创检测移植冠状动脉疾病。

• DOI: 10.1016/j.healun.2012.06.001
• 发表时间: 2012
• 期刊: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
• 作者: Madani,MohammadH;Canter,CharlesE;Balzer,DavidT;Watkins,MaryP;Wickline,SamuelA
• 通讯作者: Wickline,SamuelA