课题基金 / 基金详情

Molecular Pathways of Interleukin-13 in Cutaneous T-cell Lymphoma

Molecular Pathways of Interleukin-13 in Cutaneous T-cell Lymphoma
皮肤 T 细胞淋巴瘤中 IL-13 的分子通路
批准号:
9178480
负责人:
PATRIZIA FUSCHIOTTI
金额:
$21.16万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-07-01 至 2018-06-30

项目摘要

项目成果

PATRIZIA FUSCHIOTTI的其他基金

相似基金

相关文献

中文摘要
翻译
摘要
英文摘要
Abstract Cutaneous T-cell lymphomas (CTCLs) are a heterogeneous group of T lymphocytes malignancies that primarily affect skin. Mycosis fungoides (MF) is the most common form of CTCL and typically runs an indolent course. However, in a significant number of patients the disease may progress and tumor cells spread to other sites of the body leading to a fatal outcome. Diagnosis of MF, especially in the early stages, is difficult to establish due to the absence of specific markers for malignant lymphocytes. Limited treatment options are available for patients with advanced-stage MF, a reflection of the poor understanding of disease pathogenesis. We have recently demonstrated that IL-13 and its receptors represent novel markers of malignancy in MF. Our studies further implicated IL-13 signaling via the Signal Transducer and Activator of Transcription-6 (STAT-6) protein. Significantly, we found high numbers of activated STAT-6+ cells in the affected skin of MF patients, particularly in advanced stages. Here we propose to analyze the molecular pathways of IL-13 signaling in malignant cells from aggressive forms of MF. Our central hypothesis is that STAT-6 is a major factor in the pathogenesis of MF that is critical in promoting disease progression and represents a potential target for therapy. The Specific Aims of this proposal are based solidly on our previous results and focus on identifying the unique role of STAT-6 in the pathogenesis of MF, thus shedding light on the molecular mechanisms underlying IL-13-induced tumor cell proliferation in MF. Identifying the mechanisms of MF pathogenesis will reveal novel diagnostic agents and molecular targets, leading to innovative therapies against this disease.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Pathogenesis of systemic sclerosis: role of the skin-resident CD8+ T cells
Pathogenesis of systemic sclerosis: role of the skin-resident CD8+ T cells
Pathogenesis of systemic sclerosis: role of the skin-resident CD8+ T cells
海外基金