Early-life effects on adult physical activity

 描述(由申请人提供)：这个项目的目标是利用一种新颖的多基因小鼠模型来表征早期生活对成人体力活动水平的影响。选择培育的高跑步者和未选择的对照品系的小鼠将接受早期生活锻炼和/或“西式”饮食(高脂肪和高糖)。三个独立的实验将对(1)母亲从受孕前到分娩(产前)，(2)母亲从分娩到她们的后代开始独立进食(出生后早期)进行这些治疗，以及(3) 从断奶到性成熟(幼年期)的后代。然后将对成年雄性后代的特征进行表征，包括自愿在轮子上锻炼、在家中笼子里自发的身体活动、食物消耗、身体成分、基础代谢率、最大有氧能力、饮食偏好以及其他与身体活动有关的生理和行为特征。这一结果不仅将为研究早睡环境对成人活动水平的影响和相关措施提供新的见解，还将为这些影响与遗传背景的相互作用提供新的见解。这项研究的相关结果将提供新的信息，说明成年人的身体活动水平如何在生命早期(产前、出生后早期和青少年时期)通过饮食和锻炼而改变。这项工作的发现可能会导致 开发可转化为人类临床干预措施的行为或饮食干预措施，以预防肥胖、代谢综合征、2型糖尿病、心血管疾病和骨关节炎等与缺乏运动相关的健康问题。

 DESCRIPTION (provided by applicant): This goal of this project is to characterize early-life effects on adult levels of physical activity, using a novel, polygenic mouse model. Selectively bred High Runner and non-selected Control lines of mice will be subjected to early-life exercise and/or "Western" diet (high in fat and sugar). Three separate experiments will apply these treatments to (1) mothers from before conception to parturition (prenatal period), (2) mothers from parturition until their offspring begin to eat independently (early postnatal period), and (3) offspring from weaning until sexual maturation (juvenile period). Traits of their adult male offspring will then be characterized, including voluntary exercise on wheels, spontaneous physical activity in the home cage, food consumption, body composition, basal metabolic rate, maximal aerobic capacity, dietary preferences, and other physiological and behavioral traits related to physical activity. Results will provide novel insights not only into effects of early-lie environment on adult activity levels and related measures, but also into interactions of these effects with genetic background. Relevance Results of this research will provide novel information on how adult levels of physical activity may be altered by diet and exercise during early life (prenatal, early postnatal, and juvenile periods). Findings from this work could lead to development of behavioral or dietary interventions that could be translated into human clinical interventions to prevent such inactivity-related health problems as obesity, the metabolic syndrome, Type 2 diabetes, cardiovascular diseases, and osteoarthritis.