Early-life effects on adult physical activity

 描述（由申请人提供）：本项目的目的是使用一种新的多基因小鼠模型来表征早期生活对成年人体力活动水平的影响。选择性繁殖的High Runner和非选择的对照系小鼠将经历早期生活锻炼和/或“西方”饮食（高脂肪和糖）。三个独立的实验将这些治疗应用于（1）从怀孕前到分娩的母亲（产前期），（2）从分娩到其后代开始独立进食的母亲（产后早期），和（3） 从断奶到性成熟（幼年期）的后代。然后将表征其成年雄性后代的特征，包括自愿在轮子上运动、在饲养笼中自发的身体活动、食物消耗、身体组成、基础代谢率、最大有氧能力、饮食偏好以及与身体活动相关的其他生理和行为特征。研究结果将提供新的见解，不仅对成人活动水平和相关措施的早期谎言环境的影响，而且这些影响与遗传背景的相互作用。这项研究的结果将提供新的信息，成年人的身体活动水平可能会改变饮食和运动在生命早期（产前，产后早期和青少年时期）。这项工作的结果可能导致 开发行为或饮食干预措施，这些措施可以转化为人类临床干预措施，以预防肥胖、代谢综合征、2型糖尿病、心血管疾病和骨关节炎等与不活动相关的健康问题。

 DESCRIPTION (provided by applicant): This goal of this project is to characterize early-life effects on adult levels of physical activity, using a novel, polygenic mouse model. Selectively bred High Runner and non-selected Control lines of mice will be subjected to early-life exercise and/or "Western" diet (high in fat and sugar). Three separate experiments will apply these treatments to (1) mothers from before conception to parturition (prenatal period), (2) mothers from parturition until their offspring begin to eat independently (early postnatal period), and (3) offspring from weaning until sexual maturation (juvenile period). Traits of their adult male offspring will then be characterized, including voluntary exercise on wheels, spontaneous physical activity in the home cage, food consumption, body composition, basal metabolic rate, maximal aerobic capacity, dietary preferences, and other physiological and behavioral traits related to physical activity. Results will provide novel insights not only into effects of early-lie environment on adult activity levels and related measures, but also into interactions of these effects with genetic background. Relevance Results of this research will provide novel information on how adult levels of physical activity may be altered by diet and exercise during early life (prenatal, early postnatal, and juvenile periods). Findings from this work could lead to development of behavioral or dietary interventions that could be translated into human clinical interventions to prevent such inactivity-related health problems as obesity, the metabolic syndrome, Type 2 diabetes, cardiovascular diseases, and osteoarthritis.