Evolution and Treatment Response of Brain, Breast, and Hematologic Malignancies

 描述(由申请人提供)：Dana-Farber癌症研究所-物理科学-肿瘤学中心(DFCI-PSOC)将利用物理和实验科学的方法促进对癌症进化和治疗反应的理解。PSOC将围绕我们以物理科学为基础的框架组建和发展一个跨学科的团队、研究和培训计划以及基础设施，以解决癌症研究中的一个基本问题：我们如何利用基于物理科学的量化理解肿瘤进化和治疗反应的时空方面来改善患者护理？我们的跨学科中心将单独并通过合作的跨网络活动，开发和测试基于物理科学的实验和理论概念，以补充和促进我们目前对癌症生物学和肿瘤学的理解。具体地说，DFCI-PSOC的目标是(I)组建和发展一个综合的跨学科研究团队，该团队将密切合作，开发和验证癌症演变和治疗反应的数学建模策略，并利用这些策略来确定血液、脑和乳腺恶性肿瘤的最佳治疗干预计划，最终目标是改善患者护理。(Ii)单独开发和测试 并通过协作网络活动，为动物模型和人类癌症样本的单细胞行为的基于物理科学的测量策略提供信息，并利用这些测量为血液、脑和乳腺恶性肿瘤的治疗反应提供数学建模策略。(Iii)将物理学的观点融入癌症研究，以补充和扩展我们目前在许多长度和时间尺度上对癌症的理解，最终目标是改进癌症的预防、检测、诊断、预后和治疗。(Iv)向PSOC网络和更广泛的科学界传播我们的发现、途径和方法，并实施与患者、学生、研究人员、倡导者和普通公众互动的教育和外联计划。总之，在DFCI-PSOC内开发的方法和方法将使我们能够进一步了解癌症演变和治疗反应背后的物理原理，最终目标是为血液、脑和乳腺恶性肿瘤设计最佳干预策略。

 DESCRIPTION (provided by applicant): The Dana-Farber Cancer Institute-Physical Sciences-Oncology Center (DFCI-PSOC) will promote the understanding of cancer evolution and treatment responses utilizing approaches from the physical and experimental sciences. The PSOC will assemble and develop a trans- disciplinary team, research and training programs, and infrastructure organized around our physical sciences-based framework to address a fundamental question in cancer research: how can we utilize a quantitative, physical sciences-based understanding of the spatio-temporal aspects tumor evolution and treatment response to improve patient care? Our trans-disciplinary center will develop and test, individually and through collaborative trans-network activities, physical sciences-based experimental and theoretical concepts that complement and advance our current understanding of cancer biology and oncology. Specifically, the DFCI-PSOC aims to (i) Assemble and develop an integrated trans-disciplinary research team that will work closely together to develop and validate mathematical modeling strategies of cancer evolution and treatment response, and utilize these strategies to identify best therapeutic intervention schedules for hematologic, brain and breast malignancies, with the ultimate goal of improving patient care. (ii) Develop and test, individually and through collaborative network activities, strategies for physical sciences-based measurements of single cell behavior of both animal model and human cancer samples, and utilize these measurements to inform mathematical modeling strategies of treatment response in hematologic, brain and breast malignancies. (iii) Integrate physical sciences perspectives into cancer research to complement and expand on our current understanding of cancer across many length-scales and time-scales, with the ultimate goal of improving cancer prevention, detection, diagnosis, prognosis, and therapy. (iv) Disseminate our findings, approaches and methodologies to the PSOC network and the wider scientific community as well as implement education and outreach programs to interact with patients, students, researchers, advocates, and the general public. Together, the approaches and methodologies developed within the DFCI-PSOC will enable us to further our understanding of the physical principles underlying cancer evolution and treatment response with the ultimate goal of designing optimum intervention strategies for hematologic, brain and breast malignancies.