NorCal - Coordinating Stroke Center

NorCal - 中风协调中心

• 批准号: 9119876
• 负责人: WADE S SMITH
• 金额: $ 37.46万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9119876
• 关键词: Address; Ancillary Study; Asian Americans; Asians; Blood Vessels; Brain; California; Childhood; Childhood stroke; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Design; Clinical Trials Network; Collaborations; Communities; Computerized Medical Record; Coupled; Data Analyses; Disease; Emergency treatment; Enrollment; Environment; Faculty; Fellowship; Funding; Future; General Hospitals; Health; Healthcare; Hispanics; Hospitals; Individual; Institution; Internet; Intervention Studies; Lead; Leadership; Medical center; Mentorship; Methods; Monitor; Multi-Institutional Clinical Trial; National Institute of Neurological Disorders and Stroke; Neurological emergencies; Neurology; Observational Study; Outcome; Participant; Patients; Pediatric Hospitals; Phase; Phase I/II Trial; Phase III Clinical Trials; Play; Population; Population Heterogeneity; Positioning Attribute; Prevention; Process; Records; Recovery; Recruitment Activity; Registries; Research; Research Design; Research Infrastructure; Research Personnel; Research Training; Role; San Francisco; Science; Site; Stroke; Stroke prevention; Structure; Training; Training Programs; Translational Research; Trust; United States National Institutes of Health; Universities; University Hospitals; base; career development; data management; design; experience; falls; implementation research; implementation trial; improved; innovation; member; neuroimaging; next generation; notch protein; novel strategies; patient population; pediatric patients; programs; racial diversity; scale up; success; treatment trial; trial design

DESCRIPTION (provided by applicant): UCSF and Kaiser Permanente Northern California are teaming up to create the Northern California Regional Coordinating Stroke Center (NorCal-CSC) as one of the 25 sites in consideration for the Stroke Trials Network. NorCal-CSC combines the brain trust of stroke researchers at UCSF and Kaiser and leverages the infrastructure for multicenter research at these institutions that is already in existence. UCSF has been a leader in stroke research for over 2 decades; the creation of NorCal-CSC allows our combined efforts to crystalize into an efficient center that has expertise in Phase 1 and 2 trials and broad access to patient populations for large phase 3 trials as well. Kaiser Permanente Northern California covers over 3 million lives as registered patients, and coupled with a high-quality comprehensive electronic medical record, our ability to recruit patients for phase 3 trials of prevention and recovery is likely unparalleled. NorCal-CSC has many leaders in academic stroke research including Dr. S. Claiborne Johnston, Dr. Donald Easton and Dr. Wade Smith (PI) who will solicit fresh, meaningful clinical trial ideas from the broad range of stroke researchers at UCSF and Kaiser and present these to the STN as a whole for consideration. These leaders have led major, multi-center clinical trials and have extensive experience with the NIH funded NETT. This involvement with the NETT provides excellent experience to maintain a similar U-10 supported infrastructure for stroke research. NorCal-CSC will combine UC Medical Center (UCMC), San Francisco General Hospital (SFGH), UC-Fresno, and 2 Kaiser hospitals - all of which have primary stroke center status. Additionally, 3 of these hospitals have endovascular capability and all have capacity for advanced neuroimaging. Northern California is racially diverse with Asian (10-33%) and Hispanic patients (9-50%) representing significant populations across our sites; this racial diversity allows NorCal-CSC to study stroke prevention, treatment and recovery in these diverse populations. NorCal-CSC will also provide an accredited 2-year vascular neurology fellowship that includes advanced training in clinical trial design, trial implementation and center administration so as to prepare these individuals as leaders of stroke research in the future.

描述(由申请人提供)： 加州大学旧金山分校和加州北部Kaiser Permanente正在联手创建北加州区域协调卒中中心(NorCal-CSC)，作为卒中试验网络考虑的25个地点之一。NorCal-CSC结合了加州大学旧金山分校和Kaiser的中风研究人员的智囊团，并利用这些机构现有的多中心研究基础设施。20多年来，加州大学旧金山分校一直是卒中研究领域的领导者；NorCal-CSC的成立使我们的共同努力能够使我们成为一个高效的中心，该中心拥有1期和2期试验的专业知识，并在大型3期试验中广泛接触患者群体。Kaiser Permanente North California作为注册患者覆盖了300多万人的生命，再加上高质量的全面电子病历，我们招募患者进行预防和康复第三阶段试验的能力可能是无与伦比的。NorCal-CSC拥有许多中风学术研究领域的领导者，包括S.Claiborne Johnston博士、Donald Easton博士和Wade Smith博士(PI)，他们将从加州大学旧金山分校和Kaiser的广泛中风研究人员那里征求新鲜、有意义的临床试验想法，并将这些想法提交给STN作为一个整体进行考虑。这些领导者领导了重大的多中心临床试验，并在NIH资助的NETT方面拥有丰富的经验。与NETT的合作为维持类似的U-10支持的中风研究基础设施提供了极好的经验。NorCal-CSC将合并加州大学医学中心(UCMC)、旧金山综合医院(SFGH)、UC-Fresno和2家Kaiser医院-所有这些医院都具有初级中风中心的地位。此外，这些医院中有3家具有血管内能力，所有医院都具有先进的神经成像能力。加利福尼亚州北部具有种族多样性，亚裔患者(10%-33%)和西班牙裔患者(9%-50%)代表了我们网站上的大量人群；这种种族多样性使NorCal-CSC能够研究这些不同人群的中风预防、治疗和康复。NorCal-CSC还将提供经过认可的为期两年的血管神经学奖学金，其中包括临床试验设计、试验实施和中心管理方面的高级培训，以便为这些人未来成为中风研究的领导者做好准备。