NorCal - Coordinating Stroke Center

NorCal - 中风协调中心

• 批准号: 9321619
• 负责人: WADE S SMITH
• 金额: $ 36.88万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9321619
• 关键词: Accreditation; Address; Ancillary Study; Asian Americans; Asians; Blood Vessels; Brain; California; Childhood; Childhood stroke; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Design; Clinical Trials Network; Collaborations; Communities; Computerized Medical Record; Coupled; Crystallization; Data Analyses; Disease; Enrollment; Environment; Faculty; Fellowship; Funding; Future; General Hospitals; Health; Healthcare; Hispanics; Hospitals; Individual; Institution; Internet; Intervention Studies; Lead; Leadership; Medical center; Mentorship; Methods; Monitor; Multi-Institutional Clinical Trial; National Institute of Neurological Disorders and Stroke; Neurological emergencies; Neurology; Observation in research; Outcome; Participant; Patient Recruitments; Patients; Pediatric Hospitals; Phase; Phase I/II Trial; Phase III Clinical Trials; Play; Population; Population Heterogeneity; Positioning Attribute; Prevention trial; Process; Program Development; Records; Recovery; Recruitment Activity; Registries; Research; Research Design; Research Infrastructure; Research Personnel; Research Training; Role; San Francisco; Science; Site; Stroke; Stroke prevention; Structure; Training; Training Programs; Translational Research; Trust; United States National Institutes of Health; Universities; base; career development; data management; design; experience; falls; implementation research; improved; innovation; member; neuroimaging; next generation; notch protein; novel strategies; patient population; pediatric patients; programs; public health relevance; racial diversity; scale up; success; treatment trial; trial design

DESCRIPTION (provided by applicant): UCSF and Kaiser Permanente Northern California are teaming up to create the Northern California Regional Coordinating Stroke Center (NorCal-CSC) as one of the 25 sites in consideration for the Stroke Trials Network. NorCal-CSC combines the brain trust of stroke researchers at UCSF and Kaiser and leverages the infrastructure for multicenter research at these institutions that is already in existence. UCSF has been a leader in stroke research for over 2 decades; the creation of NorCal-CSC allows our combined efforts to crystalize into an efficient center that has expertise in Phase 1 and 2 trials and broad access to patient populations for large phase 3 trials as well. Kaiser Permanente Northern California covers over 3 million lives as registered patients, and coupled with a high-quality comprehensive electronic medical record, our ability to recruit patients for phase 3 trials of prevention and recovery is likely unparalleled. NorCal-CSC has many leaders in academic stroke research including Dr. S. Claiborne Johnston, Dr. Donald Easton and Dr. Wade Smith (PI) who will solicit fresh, meaningful clinical trial ideas from the broad range of stroke researchers at UCSF and Kaiser and present these to the STN as a whole for consideration. These leaders have led major, multi-center clinical trials and have extensive experience with the NIH funded NETT. This involvement with the NETT provides excellent experience to maintain a similar U-10 supported infrastructure for stroke research. NorCal-CSC will combine UC Medical Center (UCMC), San Francisco General Hospital (SFGH), UC-Fresno, and 2 Kaiser hospitals - all of which have primary stroke center status. Additionally, 3 of these hospitals have endovascular capability and all have capacity for advanced neuroimaging. Northern California is racially diverse with Asian (10-33%) and Hispanic patients (9-50%) representing significant populations across our sites; this racial diversity allows NorCal-CSC to study stroke prevention, treatment and recovery in these diverse populations. NorCal-CSC will also provide an accredited 2-year vascular neurology fellowship that includes advanced training in clinical trial design, trial implementation and center administration so as to prepare these individuals as leaders of stroke research in the future.

描述（由申请人提供）： 加州大学旧金山分校和凯撒永久北方加利福尼亚州正在联手创建北方加州地区协调中风中心（NorCal-CSC）作为25个网站之一，在考虑中风试验网络。NorCal-CSC结合了UCSF和Kaiser中风研究人员的智囊团，并利用这些机构已经存在的多中心研究基础设施。20多年来，UCSF一直是中风研究的领导者; NorCal-CSC的创建使我们的共同努力能够结晶为一个高效的中心，该中心拥有1期和2期试验的专业知识，并广泛接触大型3期试验的患者人群。Kaiser Permanente北方加州的注册患者人数超过300万，再加上高质量的综合电子病历，我们招募患者进行预防和康复3期试验的能力可能是无与伦比的。NorCal-CSC在学术中风研究方面有许多领导者，包括S。克莱本约翰斯顿，唐纳德伊斯顿博士和韦德史密斯博士（PI）谁将征求新鲜的，有意义的临床试验的想法，从广泛的中风研究人员在加州大学旧金山分校和凯撒，并提出这些作为一个整体的考虑。这些领导人领导了主要的多中心临床试验，并在NIH资助的NETT方面拥有丰富的经验。这种参与NETT提供了极好的经验，以维持一个类似的U-10支持中风研究的基础设施。NorCal-CSC将联合收割机加州大学医学中心（UCMC）、旧金山弗朗西斯科总医院（SFGH）、加州大学弗雷斯诺分校和2家凯泽医院合并，所有这些医院都具有初级卒中中心的地位。此外，其中3家医院具有血管内治疗能力，并且都具有先进的神经成像能力。北方加州的种族多样性，亚洲（10-33%）和西班牙裔患者（9-50%）代表了我们研究中心的重要人群;这种种族多样性使NorCal-CSC能够在这些不同人群中研究卒中预防、治疗和恢复。NorCal-CSC还将提供为期2年的血管神经病学奖学金，包括临床试验设计，试验实施和中心管理方面的高级培训，以便为这些人将来成为中风研究的领导者做好准备。